An experimental study of the dual modulation of the colchicine-induced rat model of Alzheimer’s disease by superparamagnetic iron oxide nanoparticles (SPIONs) and the soluble product of Dipylidium caninum adult worm DOI Creative Commons

Awatef Mohamed El-sharkawy,

Faika Hassanein, Samia S. Abouelkheir

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(6), С. e0324191 - e0324191

Опубликована: Июнь 3, 2025

Alzheimer's disease, affecting 7.24 million globally, requires combination therapies, including cholinesterase inhibitors and immunotherapy, for optimal management, emphasizing the benefits of these treatments. The current study investigated potential synergy between superparamagnetic iron oxide nanoparticles (SPIONs) a soluble product Dipylidium caninum adult worms to enhance biochemical cognitive changes in colchicine-induced rat model disease. involved 50 male albino rats randomly assigned into five groups: group I, negative control; II, positive III, D. excretory-secretory (ESP)-intervened group; IV, SPION-intervened V, SPIONs worm ESP-intervened group. Each consisted 10 rats. compared abilities three intervention groups control using MANOVA test, revealing significant fit (p = 0.000) large effect size (partial eta squared 0.750) improvement. same results were found all tests, amyloid beta (AB1-42), nuclear factor-kappa B (NF-kB), malondialdehyde (MDA), superoxide dismutase (SOD). sizes (0.551, 0.729, 0.674, 0.445, respectively), models (P 0.000). When comparing experimental pairwise, it was clear that V most effective therapy, as had smallest mean difference across markers when Regarding changes, both multivariate test tests between-subject effects seven parameters significant, with P values ≤ 0.05 due partial above 0.1. However, passive avoidance (PA) effect, initial latency locomotor activity have medium 0.01 0.1 (0.061 0.018, respectively). Pairwise comparisons revealed IV (SPION-intervened) parameters, making best therapy changes. Log Rank (Mantel-Cox) Kaplan-Meier curve indicated least timing needed normalize 20 days at median point 0.5, III (D. group) having significantly different (Chi-Square 85.490,

Язык: Английский

From Traditional Efficacy to Drug Design: A Review of Astragali Radix DOI Creative Commons
Xiaojie Jin, Huijuan Zhang,

Xiaorong Xie

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 413 - 413

Опубликована: Март 14, 2025

Astragali Radix (AR), a traditional Chinese herbal medicine, is derived from the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (A. mongholicus, AMM) or Bge membranaceus, AM). According to medicine (TCM) theory, AR believed tonify qi, elevate yang, consolidate body’s surface reduce sweating, promote diuresis and swelling, generate body fluids, nourish blood. It has been widely used treat general weakness chronic illnesses improve overall vitality. Extensive research identified various medicinal properties AR, including anti-tumor, antioxidant, cardiovascular-protective, immunomodulatory, anti-inflammatory, anti-diabetic, neuroprotective effects. With advancements in technology, methods such as computer-aided drug design (CADD) artificial intelligence (AI) are increasingly being applied development TCM. This review summarizes progress on over past decades, providing comprehensive overview its efficacy, botanical characteristics, distribution, chemical constituents, phytochemistry. aims enhance researchers’ understanding pharmaceutical potential, thereby facilitating further utilization.

Язык: Английский

Процитировано

0
Rodent Models for Alzheimer Disease: Experimental Induction, Pathophysiological Mechanisms, and Biomarker Profiling DOI

Riddhi Rane,

Bhagya V Rao,

Joshnavi Tadimari

и другие.

Опубликована: Май 1, 2025

Background Alzheimer’s disease (AD), the most common neurodegenerative disorder, is driven by amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), neuroinflammation, and oxidative stress. Rodent models are critical for studying its multifactorial etiology, combining genetic, environmental, epigenetic factors. This review evaluates rodent AD models, including chemical induction (e.g., aluminum, scopolamine) transgenic systems 5xFAD, APP/PS1). Chemical mimic sporadic triggers, while transgenics replicate genetic mutations. Combinatorial approaches toxin- exposed transgenics) address limitations. Biomarkers such as Aβ/tau ratios, neuroinflammatory cytokines (TNF-α, IL-1β), stress markers (MDA, SOD) validate pathology, measured via ELISA, PET imaging, omics technologies.

Язык: Английский

Процитировано

0
An experimental study of the dual modulation of the colchicine-induced rat model of Alzheimer’s disease by superparamagnetic iron oxide nanoparticles (SPIONs) and the soluble product of Dipylidium caninum adult worm DOI Creative Commons

Awatef Mohamed El-sharkawy,

Faika Hassanein, Samia S. Abouelkheir

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(6), С. e0324191 - e0324191

Опубликована: Июнь 3, 2025

Alzheimer's disease, affecting 7.24 million globally, requires combination therapies, including cholinesterase inhibitors and immunotherapy, for optimal management, emphasizing the benefits of these treatments. The current study investigated potential synergy between superparamagnetic iron oxide nanoparticles (SPIONs) a soluble product Dipylidium caninum adult worms to enhance biochemical cognitive changes in colchicine-induced rat model disease. involved 50 male albino rats randomly assigned into five groups: group I, negative control; II, positive III, D. excretory-secretory (ESP)-intervened group; IV, SPION-intervened V, SPIONs worm ESP-intervened group. Each consisted 10 rats. compared abilities three intervention groups control using MANOVA test, revealing significant fit (p = 0.000) large effect size (partial eta squared 0.750) improvement. same results were found all tests, amyloid beta (AB1-42), nuclear factor-kappa B (NF-kB), malondialdehyde (MDA), superoxide dismutase (SOD). sizes (0.551, 0.729, 0.674, 0.445, respectively), models (P 0.000). When comparing experimental pairwise, it was clear that V most effective therapy, as had smallest mean difference across markers when Regarding changes, both multivariate test tests between-subject effects seven parameters significant, with P values ≤ 0.05 due partial above 0.1. However, passive avoidance (PA) effect, initial latency locomotor activity have medium 0.01 0.1 (0.061 0.018, respectively). Pairwise comparisons revealed IV (SPION-intervened) parameters, making best therapy changes. Log Rank (Mantel-Cox) Kaplan-Meier curve indicated least timing needed normalize 20 days at median point 0.5, III (D. group) having significantly different (Chi-Square 85.490,

Язык: Английский

Процитировано

0