Deleted Journal,
Год журнала:
2024,
Номер
6(15), С. 318 - 323
Опубликована: Янв. 1, 2024
What
is
already
known
about
this
topic?
The
significant
disparities
in
global
coronavirus
disease
2019
(COVID-19)
vaccine
coverage
hamper
the
pace
of
epidemic
control.
There
a
need
to
better
understand
factors
contributing
COVID-19
vaccination
rates
across
countries.
added
by
report?
This
report
revealed
associations
between
and
various
country-level
indicators.
Better
pandemic
preparedness,
higher
levels
trust,
lower
proportion
young
population
aged
0–14
were
strongly
correlated
with
coverage.
are
implications
for
public
health
practices?
Our
findings
emphasize
enhanced
preparedness
governance,
coupled
building
trust
government
healthcare
systems.
It
also
needs
address
hesitancy
vaccinating
children
adolescents
as
campaign
progresses.
We
investigated
the
design
and
analysis
of
observational
booster
vaccine
effectiveness
(VE)
studies
by
performing
a
scoping
review
VE
literature
with
focus
on
study
analytic
choices.
then
applied
20
different
approaches,
including
those
found
in
literature,
to
single
dataset
from
Michigan
Medicine.
identified
80
our
review,
over
150
million
observations
total.
that
while
protection
against
infection
is
variable
dependent
several
factors
population
time
period,
both
monovalent
boosters
particularly
bivalent
offer
strong
severe
COVID-19.
In
addition,
analyses
disease
outcome
(hospitalization,
intensive
care
unit
admission,
or
death)
appear
be
more
robust
choices
than
an
endpoint.
terms
choices,
we
test-negative
designs
their
variants
may
advantages
statistical
efficiency
compared
cohort
designs.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Авг. 23, 2022
Summary
The
SARS-CoV-2
Omicron
variant
has
challenged
the
control
of
COVID-19
pandemic
even
in
highly
vaccinated
countries.
While
a
second
booster
mRNA
vaccines
improved
immunity
against
SARS-CoV-2,
humoral
and
cellular
responses
induced
by
an
inactivated
vaccine
have
not
been
studied.
In
context
phase
3
clinical
study,
we
report
that
CoronaVac
®
increased
neutralizing
response
ancestral
virus
yet
showed
poor
neutralization
variant.
Additionally,
isolated
PBMCs
displayed
equivalent
activation
specific
CD4
+
T
cells
IFN-γ
production
when
stimulated
with
mega-pool
peptides
derived
from
spike
protein
or
conclusion,
dose
does
improve
compared
first
dose,
it
helps
maintaining
robust
spike-specific
cell
response.
International Journal of Travel Medicine and Global Health,
Год журнала:
2022,
Номер
10(3), С. 122 - 126
Опубликована: Авг. 11, 2022
Introduction:
Angiotensin-converting
enzyme
2
(ACE2)
is
the
central
receptor
of
coronavirus
disease
2019
(COVID-19)
in
host
cells.
Genetic
polymorphisms
ACE2
gene
may
promote
cardiovascular
and
systemic
inflammatory
injury
a
patient
affected
by
COVID-19.
Thus,
genetic
background
account
for
substantial
inter-individual
diversity
illness
susceptibility
or
severity.
Our
study
was
conducted
to
find
significant
relationship
between
rs4646142
rs2285666
severe
acute
respiratory
syndrome
(SARS-CoV-2).
Methods:
In
this
study,
we
randomly
selected
230
samples,
including
76
patients
with
clinical
symptoms
154
mild
(the
positive
case
COVID-19
confirmed
real-time
reverse
transcriptase
polymerase
chain
reaction
[RT-PCR]
assay).
Then,
performed
DNA
extraction
investigated
RFLP-PCR
method
TaqI
Alu1
restriction
enzymes.
Results:
The
population
included
107
men
123
women,
mean
(±SD)
age
participants
42.66±10.2.
First,
levels
IgM
IgG
were
examined,
association
observed
level
two
groups
symptoms,
as
opposed
IgG.
Meanwhile,
no
difference
severity
Conclusion:
To
better
understand
variations
people’s
COVID-19,
designed
evaluate
various
infection
risk
SARS-CoV-2.
However,
statistical
discovered.
Deleted Journal,
Год журнала:
2024,
Номер
6(15), С. 318 - 323
Опубликована: Янв. 1, 2024
What
is
already
known
about
this
topic?
The
significant
disparities
in
global
coronavirus
disease
2019
(COVID-19)
vaccine
coverage
hamper
the
pace
of
epidemic
control.
There
a
need
to
better
understand
factors
contributing
COVID-19
vaccination
rates
across
countries.
added
by
report?
This
report
revealed
associations
between
and
various
country-level
indicators.
Better
pandemic
preparedness,
higher
levels
trust,
lower
proportion
young
population
aged
0–14
were
strongly
correlated
with
coverage.
are
implications
for
public
health
practices?
Our
findings
emphasize
enhanced
preparedness
governance,
coupled
building
trust
government
healthcare
systems.
It
also
needs
address
hesitancy
vaccinating
children
adolescents
as
campaign
progresses.
