Network homeostasis: functional brain network alterations and relapse in remitted late-life depression DOI
Andrew Gerlach, Helmet T. Karim, Antonija Kolobaric

и другие.

Опубликована: Окт. 21, 2024

Abstract In this study, we aim to identify neurobiological factors that predict relapse risk in late-life depression (LLD). We recruited 145 older adults (age ≥ 60): 102 recently remitted LLD participants and 43 healthy comparisons. Participants underwent baseline MRI evaluation of symptoms/status for up 2 years. evaluated intrinsic network connectivity 111 (39 comparisons, 47 stable remitted, 25 relapsed). had lower primarily within between the default mode (DMN), somatomotor, visual networks higher DMN executive control network. Lower somatomotor salience was associated with relapse. Notably, structure relapsed more similar comparisons than remitted. These findings indicate remission is persistent functional alterations while vulnerability may be a failure establish new homeostatic structure.

Язык: Английский

Dynamic Temporal Alterations of the Cerebellum in Parkinson's Disease With Different Dominant‐Affected Sides DOI Open Access
Lili Chen, Junling Wang, Linlin Gao

и другие.

Journal of Neuroscience Research, Год журнала: 2025, Номер 103(3)

Опубликована: Март 1, 2025

Laterality of motor deficits is a hallmark Parkinson's disease (PD), which strongly correlated with progression. The cerebellum an important node in the motor-related network PD. However, role PD lateralization remains unclear. This study enrolled 48 left-dominant-affected patients (LPD), 60 right-dominant-affected (RPD) and 92 age- sex-matched healthy controls (HCs). We utilized dynamic functional connectivity co-activation pattern analysis to investigate alterations between HCs by resting-state fMRI. Pearson partial correlation was used measure brain-clinical correlations. revealed two states five patterns during scans. Compared RPD, LPD more frequently displayed State II persisted this state for extended period. mean dwell time (MDT) rose from RPD LPD. MDT positively sleep disturbance patients. Regarding (CAPs), were less likely exhibit CAP2. demonstrate CAP1 compared HCs. metrics associated These results different dominant-affected patients, related disturbances Our findings suggest that cerebellar features may be significant factors

Язык: Английский

Процитировано

0
Seeing more than the Tip of the Iceberg: Approaches to Subthreshold Effects in Functional Magnetic Resonance Imaging of the Brain DOI Creative Commons
Benedikt Sundermann, Bettina Pfleiderer, Anke McLeod

и другие.

Clinical Neuroradiology, Год журнала: 2024, Номер 34(3), С. 531 - 539

Опубликована: Июнь 6, 2024

Many functional magnetic resonance imaging (fMRI) studies and presurgical mapping applications rely on mass-univariate inference with subsequent multiple comparison correction. Statistical results are frequently visualized as thresholded statistical maps. This approach has inherent limitations including the risk of drawing overly-selective conclusions based only selective passing such thresholds. article gives an overview both established newly emerging scientific approaches to supplement conventional analyses by incorporating information about subthreshold effects aim improve interpretation findings or leverage a wider array information. Topics covered include neuroimaging data visualization, p-value histogram analysis related Higher Criticism for detecting rare weak effects. Further examples from multivariate dedicated Bayesian provided.

Язык: Английский

Процитировано

3
Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome DOI Creative Commons
Benedikt Sundermann, Reinhold Feldmann, Christian Mathys

и другие.

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Дек. 13, 2023

Fetal alcohol syndrome (FAS) can result in cognitive dysfunction. Cognitive functions affected are subserved by few functional brain networks. Functional connectivity (FC) these networks be assessed with resting-state MRI (rs-fMRI). Alterations of FC have been reported children and adolescents prenatally exposed to alcohol. Previous reports varied substantially regarding the exact nature findings. The purpose this study was assess cognition-related young adults FAS.

Язык: Английский

Процитировано

6
Cell types associated with human brain functional connectomes and their implications in psychiatric diseases DOI Creative Commons
Pengxing Nie, Yafeng Zhan, Renrui Chen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Cell types are fundamental to the functional organization of human brain, yet specific cell clusters contributing connectomes remain unclear. Using whole-brain single-cell RNA sequencing data, we investigated relationship between cortical cluster distribution and connectomes. Our analysis identified dozens significantly associated with resting-state network connectivity, excitatory neurons predominantly driving positive correlations inhibitory negative correlations. Many these also conserved in macaques. Notably, connectivity is predicted by cellular communication among clusters. We further linked various neuropsychiatric disorders, several implicated multiple conditions. Comparative schizophrenia autism spectrum disorder revealed distinct expression patterns, highlighting disease-specific mechanisms. These findings underscore critical role shaping their implications for diseases.

Язык: Английский

Процитировано

1
The relationship between alcohol bingeing in the gestational period of wistar rats and the development of schizophrenia in the offspring adult life DOI
Amanda Kunz Godói, Lara Canever, Eduardo Pacheco Rico

и другие.

Brain Research, Год журнала: 2024, Номер 1845, С. 149270 - 149270

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

0
Network homeostasis: functional brain network alterations and relapse in remitted late-life depression DOI
Andrew Gerlach, Helmet T. Karim, Antonija Kolobaric

и другие.

Опубликована: Окт. 21, 2024

Abstract In this study, we aim to identify neurobiological factors that predict relapse risk in late-life depression (LLD). We recruited 145 older adults (age ≥ 60): 102 recently remitted LLD participants and 43 healthy comparisons. Participants underwent baseline MRI evaluation of symptoms/status for up 2 years. evaluated intrinsic network connectivity 111 (39 comparisons, 47 stable remitted, 25 relapsed). had lower primarily within between the default mode (DMN), somatomotor, visual networks higher DMN executive control network. Lower somatomotor salience was associated with relapse. Notably, structure relapsed more similar comparisons than remitted. These findings indicate remission is persistent functional alterations while vulnerability may be a failure establish new homeostatic structure.

Язык: Английский

Процитировано

0