Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

Cell Host & Microbe, Год журнала: 2023, Номер 31(6), С. 1054 - 1070.e9

Опубликована: Май 18, 2023

Язык: Английский

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Probiotics: Protecting Our Health from the Gut

Microorganisms, Год журнала: 2022, Номер 10(7), С. 1428 - 1428

Опубликована: Июль 14, 2022

The gut microbiota (GM) comprises billions of microorganisms in the human gastrointestinal tract. This microbial community exerts numerous physiological functions. Prominent among these functions is effect on host immunity through uptake nutrients that strengthen intestinal cells and involved immune response. GM are not limited to gut, but bidirectional interactions between various extraintestinal organs have been identified. These termed interorganic axes by several authors, which gut-brain, gut-skin, gut-lung, gut-heart, gut-metabolism stand out. It has shown an organism healthy or homeostasis when balance. However, altered dysbiosis represents a critical factor pathogenesis many local systemic diseases. Therefore, probiotics intervene this context, which, according published studies, allows balance be maintained GM, leading individual's good health.

Язык: Английский

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Role of Short-Chain Fatty Acids Produced by Gut Microbiota in Innate Lung Immunity and Pathogenesis of the Heterogeneous Course of Chronic Obstructive Pulmonary Disease

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4768 - 4768

Опубликована: Апрель 26, 2022

Chronic obstructive pulmonary disease (COPD) is a widespread socially significant disease. The development of COPD involves the innate immune system. Interestingly, regulation lung system related to gut microbiota. This connection due production by microorganisms short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. Nutritional disturbances changes in structure intestinal microbiota lead decrease SCFAs their effect on immunity. presence metabolic axis linking lungs plays an important role pathogenesis COPD. In addition, nature nutrition may participate clinically heterogeneous course

Язык: Английский

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The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics

Life, Год журнала: 2023, Номер 13(10), С. 2023 - 2023

Опубликована: Окт. 8, 2023

The human gut microbiota (GM) is a complex microbial ecosystem that colonises the gastrointestinal tract (GIT) and comprised of bacteria, viruses, fungi, protozoa. GM has symbiotic relationship with its host fundamental for body homeostasis. not limited to scope GIT, but there are bidirectional interactions between other organs, highlighting concept "gut-organ axis". Any deviation from normal composition GM, termed "microbial dysbiosis", implicated in pathogenesis various diseases. Only few studies have demonstrated modifications disease phenotypes, it still unknown whether an altered contributes or simply reflects status. Restoration probiotics prebiotics been postulated, evidence effects limited. Prebiotics substrates "selectively utilized by microorganisms, conferring health benefit". This study highlights vital organs demonstrates dysbiosis emergence certain representative Finally, this article focuses on potential as target therapy manipulate presents gaps literature research.

Язык: Английский

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Gut microbiota in chronic obstructive pulmonary disease varies by CT-verified emphysema status

European Clinical Respiratory Journal, Год журнала: 2025, Номер 12(1)

Опубликована: Фев. 26, 2025

Background and aim The association of the gut microbiota to chronic obstructive pulmonary disease (COPD) phenotypes is underexplored. We aimed compare stool samples from patients with COPD subjects without relate findings emphysema status, exacerbation rate, blood eosinophil levels, symptom score, lung function.

Язык: Английский

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Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections

Antibiotics, Год журнала: 2022, Номер 11(4), С. 474 - 474

Опубликована: Апрель 1, 2022

Acute and chronic lower airway disease still represent a major cause of morbidity mortality on global scale. With the steady rise multidrug-resistant respiratory pathogens, such as Pseudomonas aeruginosa Klebsiella pneumoniae, we are rapidly approaching advent post-antibiotic era. In addition, potentially detrimental novel variants viruses continuously emerge with most prominent recent example being severe acute syndrome coronavirus 2 (SARS-CoV-2). To this end, alternative preventive therapeutic intervention strategies will be critical to combat infections in future. Chronic diseases associated alterations lung gut microbiome, which is thought contribute progression increased susceptibility infection pathogens. review focus how modulating harnessing microbiome may pose strategy prevent treat pulmonary well disease.

Язык: Английский

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The treatment of Qibai Pingfei Capsule on chronic obstructive pulmonary disease may be mediated by Th17/Treg balance and gut-lung axis microbiota

Journal of Translational Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Июнь 21, 2022

Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and microbiota dysbiosis is associated with COPD. Researchers have shown T helper (Th) 17/regulatory (Treg) imbalance involved in Qibai Pingfei Capsule (QBPF) traditional Chinese medicine used to treat COPD clinically China. However, effects QBPF intervention on Th17/Treg balance gut lung are still poorly understood.This study divided rats into three groups (n = 8): control, model, group. After establishing model for four weeks administering two weeks, Th17 cells, Treg their cytokines, transcription factors, were analyzed. Furthermore, correlations between bacterial genera function immune measured.The results revealed could improve contribute new rats. Meanwhile, treatment regulate composition community structure rats, suppressing relative abundance Coprococcus_2, Prevotella_9, Blautia Mycoplasma lung, but accumulating Prevotellaceae_UCG_003 Rikenellaceae_RC9_gut_group lung. Additionally, gut-lung axis was confirmed by significant microbiota. Functional analysis showed amino acid metabolism altered Spearman correlation further enriched relationship rats.Our indicated therapeutic may be achieved maintaining cell regulating microbiota, providing references explore potential biomarkers possible mechanism

Язык: Английский

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Lung microbiome and origins of the respiratory diseases

Current Research in Immunology, Год журнала: 2023, Номер 4, С. 100065 - 100065

Опубликована: Янв. 1, 2023

The studies on the composition of human microbiomes in healthy individuals, its variability course inflammation, infection, antibiotic therapy, diets and different pathological conditions have revealed their intra inter-kingdom relationships. lung microbiome comprises major species members phylum Bacteroidetes, Firmicutes, Actinobacteria, Fusobacteria Proteobacteria, which are distributed ecological niches along nasal cavity, nasopharynx, oropharynx, trachea lungs. Commensal pathogenic maintained equilibrium as they strong Bacterial overgrowth after dysbiosis and/or imbalanced CD4+ helper T cells, CD8+ cytotoxic cells regulatory (Treg) populations can promote inflammatory reactions distress, consequently acute chronic respiratory diseases. This review is aimed to summarize latest advances resident participation most common pulmonary infections pneumonia, community-acquired pneumonia (CAP), ventilator-associated (VAP), immunodeficiency associated SARS-CoV-2-associated distress syndrome (ARDS) obstructive disease (COPD). We briefly describe physiological immunological mechanisms that selectively create advantages or disadvantages for relative growth bacterial tract. At end, we propose some directions analytical methods may facilitate identification key genera transient microbes involved diseases' initiation progression.

Язык: Английский

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Double-side role of short chain fatty acids on host health via the gut-organ axes

Animal nutrition, Год журнала: 2024, Номер 18, С. 322 - 339

Опубликована: Май 17, 2024

Short chain fatty acids (SCFA) exist in dietary foods and are produced by the fermentation of gut microbiota, considered an important element for regulating host health. Through blood circulation, SCFA obtained from have impact on intestinal health as well vital organs host. It has been recognized that is "vital organ" As microbial metabolites, could create "axis" connecting to other organs. Therefore, "gut-organ axes" become a focus research recent years analyze organism In this review, we summarized sources, absorption properties, function both peripheral tissues (brain, kidney, liver, lung, bone cardiovascular) way axes". exert beneficial pathological role various ways, which effects more pronounced. addition, reflected preventive therapeutic effects. More importantly, mechanisms behinds provided insight into SCFA, assisting development novel strategies maintaining

Язык: Английский

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A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown

Опубликована: Июнь 12, 2024

Abstract Chronic obstructive pulmonary disease (COPD) is the world's leading lung and lacks effective specific clinical strategies. Probiotics are increasingly used to support improvement of course inflammatory diseases. In this study, we evaluated potential a lactic acid bacteria (LAB) combination containing Limosilactobacillus reuteri GMNL-89 Lacticaseibacillus paracasei GMNL-133 decrease inflammation emphysema in COPD mouse model. This model was induced by intranasal stimulation with elastase LPS for 4 weeks, followed 2 weeks oral LAB administration. The results showed that decreased reduced cytokines (IL-1β, IL-6, TNF-α) tissue mice. Microbiome analysis revealed Bifidobacterium Akkermansia muciniphila , gut mice, could be restored after treatment. Microbial α-diversity lungs mice but reversed administration, which also increased relative abundance Candidatus arthromitus Burkholderia lungs. Furthermore, LAB-treated exhibited levels short-chain fatty acids, specifically acetic propionic acid, cecum. Additionally, negatively correlated C. Adlercreutzia levels. conclusion, L. demonstrates beneficial effects on experimental correlating changes microbiota, providing strategy future adjuvant therapy.

Язык: Английский

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