Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 30, 2024
Язык: Английский
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Апрель 4, 2024
It is becoming increasingly clear that the human microbiota, also known as “the hidden organ”, possesses a pivotal role in numerous processes involved maintaining physiological functions of host, such nutrient extraction, biosynthesis bioactive molecules, interplay with immune, endocrine, and nervous systems, well resistance to colonization potential invading pathogens. In last decade, development metagenomic approaches based on sequencing bacterial 16s rRNA gene via Next Generation Sequencing, followed by whole genome third generation technologies, has been one great advances molecular biology, allowing better profiling microbiota composition and, hence, deeper understanding importance etiopathogenesis different pathologies. this scenario, it utmost comprehensively characterize relation disease pathogenesis, order develop novel treatment or preventive strategies manipulating microbiota. Therefore, perspective will focus progress, challenges, promises current future technological for microbiome analysis.
Язык: Английский
Процитировано
9
MedComm, Год журнала: 2024, Номер 5(4)
Опубликована: Март 15, 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.
Язык: Английский
Процитировано
6
The Kaohsiung Journal of Medical Sciences, Год журнала: 2024, Номер 40(9), С. 780 - 788
Опубликована: Июль 29, 2024
Abstract The gut microbiota undergoes substantial development from birth, and its in the initial years of life has a potentially lifelong effect on health individual. However, various factors can disrupt microbiota, leading to condition known as dysbiosis, particularly preterm infants. Current studies involving adults have suggested that not only influences but also multidimensional effects remote organs; these pathways are often referred gut–organ axis. Imbalance may lead multiple diseases. Recent revealed dysbiosis infants cause several acute morbidities—such necrotizing enterocolitis, late‐onset sepsis, bronchopulmonary dysplasia, retinopathy prematurity—and it influence long‐term outcomes including neurodevelopment somatic growth. This review mainly presents existing evidence regarding relationships between morbidities explores role axis morbidities. paper thus offers insights into future perspectives interventions for promoting
Язык: Английский
Процитировано
6
Applied Sciences, Год журнала: 2024, Номер 14(20), С. 9383 - 9383
Опубликована: Окт. 15, 2024
The gut microbiota, recognised for its vital functions in host health, operates as an endocrine organ, exerting systemic effects beyond the gastrointestinal tract. This “virtual organ” produces hormones that influence distal organs, including brain. With diverse microbial composition, microbiota surpasses biochemical complexity of traditional generating neurotransmitters like GABA, dopamine, and serotonin. Despite challenges culturing bacteria, advances research methodologies have elucidated their role behaviour, metabolism, appetite, insulin resistance. As endocrinology continues to evolve, further exploration intricate connections between microbiome are anticipated, highlighting hormones’ pivotal dynamic host–microbiota relationship.
Язык: Английский
Процитировано
6
Current Pain and Headache Reports, Год журнала: 2024, Номер 28(5), С. 373 - 381
Опубликована: Март 2, 2024
Язык: Английский
Процитировано
5
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105990 - 105990
Опубликована: Дек. 1, 2024
The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. gut microbiota (GM) plays a pivotal role in progression these diseases, influencing brain mental health through gut-brain axis (GBA). vagus nerve significant GBA, making it key area focus potential novel therapeutic interventions. Vagus stimulation (VNS) was introduced approved as refractory forms some neuropsychological disorders, such depression epilepsy. Considering its impact on several regions that play vital part mood, motivation, affection, cognitive function, VNS has shown treating variety disorders. Harnessing to target bidirectional communication pathways linking GM VN could present an exciting approach Imbalances GM, dysbiosis, can impair between brain, contributing development shows modulating interconnected systems, helping restore balance. Interestingly, composition may also influence effectiveness VNS, modify brain's response this approach. This study provides comprehensive analysis relatively unexplored but noteworthy interaction In addition, we discussed mechanisms, potential, clinical implications GBA across
Язык: Английский
Процитировано
5
Ageing Research Reviews, Год журнала: 2023, Номер 93, С. 102130 - 102130
Опубликована: Ноя. 27, 2023
Dementia, osteoporosis, and fragility fractures are chronic diseases, often co-existing in older adults. These conditions pose severe morbidity, long-term disability, mortality, with relevant socioeconomic implications. While the research arena, discussion remains on whether dementia is cause or consequence of fractures, healthcare professionals need a better understanding interplay between such from epidemiological physiological standpoints. With this review, we summarized available literature surrounding relationship cognitive impairment, dementia, both low bone mineral density (BMD) fractures. Given strength bi-directional associations their impact quality life, shed light biological connections brain systems, presenting main mediators, including gut microbioma, pathological pathways leading to dysregulation metabolism. Ultimately, synthesized evidence about pharmacological treatments for prevention functions individuals' outcomes when coexists. Vice versa, effects symptomatic risk falls explored. Combining alongside clinical practice, discuss challenges opportunities related management adults affected by impairment at high fracture prevention, which leads not only an improvement patient health-related survival but also reduction cost socio-economic burden.
Язык: Английский
Процитировано
12
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Янв. 25, 2024
The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes the composition, abundance, diversity gut microbiota (GM). Activation multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), bile (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component multi-target advantages, can help treat altering composition regulating levels certain substances, such as reducing increasing SCFA BA contents. This review explores correlation between two provide new perspectives on treating with TCM.
Язык: Английский
Процитировано
4
Опубликована: Апрель 19, 2024
Health-Related Quality of Life (HRQoL) encompasses the comprehensive evaluation an indi-vidual's health and well-being across multiple dimensions. Mindfulness, recognized as a scientifi-cally supported strategy for anxiety management, plays role in enhancing both physical mental health. The Gut-Brain Axis (GBA) serves bidirectional communication link between gastrointestinal system central nervous system. This study aims to explore associa-tion Mindfulness factors influencing GBA healthy individuals those with Inflammatory Bowel Diseases (IBD). A cross-sectional investigation involved 338 adults, in-cluding 50 IBD patients, utilizing validated Greek scales (MAAS-15), Mediterra-nean Diet (14-MEDAS), HRQoL (EQ-5D-5L). questionnaire gathered demographic, an-thropometric, lifestyle data. Among participants, EQ-5D-5L showed moderate cor-relation MAAS-15 scale (r=0.389, p
Язык: Английский
Процитировано
4
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 20, 2025
Recent evidence supports the hypothesis of an association between gut microbiota and pathogenesis retinal eye diseases, suggesting existence a gut-eye axis. However, no data are available on possible effect optic nerve fiber maturation myelin development. We investigated impact nerves collected from neonatal young adult germ-free (GF), gnotobiotic (stably colonized with 12 bacteria strains, OMM12) control (colonized complex microbiota, CGM) mice, by performing stereological morphoquantitative analyses transmission electron microscopy gene expression analysis quantitative real-time PCR. Young GF OMM12 axons smaller hypermyelinated compared to CGM ones, while such differences were detected in nerves. The transcription factors Olig1, Olig2, Sox10 (oligodendrocyte myelination positive regulators) downregulated mice respective neonates. Such developmental downregulation was not observed nerves, that absence prolongs stimulation myelination, possibly through mechanisms yet be identified. Altogether, these underscore pivotal role driving contributing our knowledge about both axis gut-brain axis, opening new horizons for further investigations will explore also pathologies, injuries regeneration associated nerve.
Язык: Английский
Процитировано
0