Association between drinking patterns and diabetic kidney disease in United States adults: a cross-sectional study based on data from NHANES 1999–2016

Renal Failure, Год журнала: 2025, Номер 47(1)

Опубликована: Янв. 22, 2025

This cross-sectional study aimed to investigate the association between drinking patterns and prevalence of diabetic kidney disease (DKD) among adults in United States. Data were analyzed from NHANES surveys conducted 1999 2016, including 26,473 participants. Drinking categorized by frequency (weekly, monthly, or yearly) quantity (light, moderate, heavy, based on daily consumption). Among participants with diabetes, DKD was defined using albumin-to-creatinine ratio (ACR ≥30 mg/g) estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2). Multivariable logistic regression models used evaluate associations, adjusting for potential confounders across four models. Subgroup analyses performed assess effects modification age, sex, race, BMI. US (mean 46.6 years; 53.7% male). After multiple confounders, heavy alcohol consumption associated a higher risk than light (OR = 1.23, 95% CI, 1.04-1.46; p 0.016). Conversely, moderate (3-4 days per week, 2-5 month, 3-126 year) reduced 0.67, 0.49-0.91; OR 0.75, 0.56-0.99, 0.71, 0.58-0.86, respectively). A nonlinear observed terms weekly yearly days. highlights importance behavior management disease. Daily an increased DKD, whereas risk. These findings suggest that may not exacerbate renal burden individuals diabetes provide new perspectives clinical interventions.

Язык: Английский

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Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1888 - 1888

Опубликована: Фев. 4, 2024

The process of aging is accompanied by a dynamic restructuring the immune response, phenomenon known as immunosenescence. Further, damage to endothelium can be both cause and consequence many diseases, especially in elderly people. purpose this study was carry out immunological biochemical profiling people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), subcortical vascular dementia (SIVD). Socio-demographic, lifestyle, cognitive data were obtained. Biochemical, hematological, analyses carried out, extracellular vesicles (EVs) endothelial CD markers assessed. greatest number significant deviations from conditionally healthy donors (HDs) same age registered SIVD group, total 20, which 12 specific six non-specific but maximal differences (as compared other three groups) HDs group. for MOCA (Montreal Cognitive Impairment Scale), MMSE (Mini Mental State Examination) life satisfaction self-assessment scores, decrease albumin levels, ADAMTS13 (a Disintegrin Metalloproteinase Thrombospondin Type 1 motif, member 13) activity, an increase VWF (von Willebrand factor) level. Considering changes parameters (mostly Th17-like cells) (CD144 CD34), repair impaired extent DM AIS patients showed HD controls, including These high NEFAs (non-esterified fatty acids) CD31 CD147 EVs. lowest CCCI nine total. There controls no specifics just one difference control parameters, α1-AGP (alpha acid glycoprotein, orosomucoid). Besides patients, impairments also complete absence such (SIVD group). On hand, microvascular seemed latter considering indicators ADAMTS13. In maximum response registered, mainly cells. reaction not pronounced groups may indicate initial stages and/or compensatory nature organic (remodeling). At time, indicated persistent remodeling microvessels, inflammation, anabolic function liver tissues. obtained support two interrelated assumptions. Taking into account primary factors that trigger pathological processes associated pathology related first assumption purine degradation skeletal muscle major factor production uric acid, followed its non-muscle cells, main are Another therapeutic levels progenitor cells have effect reducing risk cerebrovascular disease neurodegenerative diseases.

Язык: Английский

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Alcohol consumption and the risk of all-cause and cause-specific mortality—a linear and nonlinear Mendelian randomization study

International Journal of Epidemiology, Год журнала: 2024, Номер 53(2)

Опубликована: Фев. 14, 2024

Many observational studies support light-to-moderate alcohol intake as potentially protective against premature death. We used a genetic approach to evaluate the linear and nonlinear relationships between consumption mortality from different underlying causes.

Язык: Английский

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Advances in Relationship Between Alcohol Consumption and Skin Diseases

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2023, Номер Volume 16, С. 3785 - 3791

Опубликована: Дек. 1, 2023

Throughout history, alcohol consumption has been an integral part of human culture. Alcohol consumption, alcoholism in particular, influences the onset and progression liver diseases, neurological disorders, multiple types cancer. However, role influencing skin diseases often overlooked. In this review, we present progress research investigating effects potential mechanisms action on acne, rosacea, psoriasis, atopic dermatitis, melanoma, non-melanoma

Язык: Английский

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Is low‐level alcohol consumption really health‐protective? A critical review of approaches to promote causal inference and recent applications

Alcohol Clinical and Experimental Research, Год журнала: 2024, Номер 48(5), С. 771 - 780

Опубликована: Апрель 21, 2024

Heavy and disordered alcohol consumption is a known risk factor for several health conditions associated with considerable disease burden. However, at low-to-moderate levels, evidence suggests that drinking reduced certain outcomes. Whether these findings represent genuine protective effects or mere methodological artifacts remains unclear, but has substantial consequences policy practice. This critical review introduces advances capable of enhancing causal inference from observational research, focusing on the 'G-methods' Mendelian Randomization. We also present evaluate recent research applying methods compare to existing base. Future directions are proposed improving our understanding relationships between long-term

Язык: Английский

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Alcohol consumption in relation to cognitive dysfunction and dementia: A systematic review and dose-response meta-analysis of comparative longitudinal studies

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102419 - 102419

Опубликована: Июль 20, 2024

Язык: Английский

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Lifestyle Factors in the Clinical Manifestation and Management of Atopic Dermatitis

Archives of Internal Medicine Research, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 1, 2025

Atopic dermatitis (AD), also known as eczema, is an inflammatory dermatologic condition that results in inflamed, itchy skin lesions. The development of this governed by a variety genetic and environmental factors including lifestyle habits. severity atopic has been attributed to be affected various factors, prompting the interest utilizing modifications form treatment for symptoms. Many research studies have conducted investigate effects different such sleep, stress, diet, smoking tobacco use, exposure temperatures humidity levels, skincare cosmetic products on symptoms, how certain habits can modified manage AD conditions. Current demonstrated significant impact some elicit with improving dermatitis, while discussing other require further determine their AD. This review article summarizes findings current literature investigates role exacerbation explores mechanisms which these behaviors trigger

Язык: Английский

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Association Between Mediterranean Diet and Other Healthy Habits and Sociodemographic Variables with the Values of Vascular and Heart Age in Spanish Workers

Nutrients, Год журнала: 2025, Номер 17(5), С. 903 - 903

Опубликована: Март 5, 2025

Introduction: The assessment of cardiovascular risk has traditionally relied on validated scales designed to estimate the likelihood experiencing a event within specific timeframe. In recent years, novel methodologies have emerged, offering more objective evaluation this through indicators such as vascular age (VA) and heart (HA). Objective: This study aimed investigate relationship between sociodemographic factors, lifestyle behaviors, their impact VA HA. Materials Methods: A dual design, encompassing both cross-sectional longitudinal retrospective approaches, was conducted among cohort employees. variables assessed included characteristics (age, sex, socioeconomic status) health-related habits (smoking, physical activity, adherence Mediterranean diet, alcohol consumption). Results: findings revealed that all analyzed were significantly associated with elevated HA values. Among these, demonstrated strongest association, odds ratios (OR) 114.91 (95% CI: 100.45-131.43) for high 34.48 31.41-37.56) VA. Conclusions: profile individuals most at encompasses males advanced age, characterized by low status, sedentary lifestyle, poor regular consumption.

Язык: Английский

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Association Between Alcohol Consumption, Other Healthy Habits and Sociodemographic Variables and the Values of Different Insulin Resistance Risk Scales in 139,634 Spanish Workers

Healthcare, Год журнала: 2025, Номер 13(8), С. 921 - 921

Опубликована: Апрель 17, 2025

Background: Alcohol consumption is a major public health concern, influencing metabolic and insulin resistance (IR). While moderate alcohol intake has been associated with potential benefits, excessive linked to IR related disorders. This study examines the association between sociodemographic variables, habits, risk using validated indices. Methods: A dual-phase was conducted, including cross-sectional analysis of 139,634 Spanish workers retrospective longitudinal follow-up 40,431 participants (2009–2019). Data on factors (age, sex socioeconomic status) habits (smoking, consumption, diet physical activity) were collected through standardized occupational assessments. assessed Triglyceride-Glucose Index (TyG), Metabolic Score for Insulin Resistance (METS-IR), Single-Point Sensitivity Estimator (SPISE-IR). Binary logistic regression used statistical analysis. Results: Age, male sex, lower status, smoking, inactivity low adherence Mediterranean significantly higher across all indices (p < 0.001). exhibited dose-dependent relationship IR, increasing IR. Longitudinal data revealed worsening profile over time, particularly among older, low-income physically inactive individuals. Conclusions: Sociodemographic lifestyle strongly influence Preventive strategies focused reducing smoking cessation promoting activity dietary improvements are essential mitigate especially in vulnerable populations. Further studies needed establish causal relationships refine intervention strategies.

Язык: Английский

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Association Analysis of Dietary Inflammatory Index and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database

Experimental and Clinical Endocrinology & Diabetes, Год журнала: 2024, Номер 132(08), С. 453 - 462

Опубликована: Апрель 25, 2024

This study focused on the association of Dietary Inflammatory Index (DII) with risk gestational diabetes mellitus (GDM) using data from National Health and Nutrition Examination Survey (NHANES).

Язык: Английский

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