Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
Triglyceride-glucose
(TyG)
related
indices,
which
serve
as
simple
markers
for
insulin
resistance,
have
been
closely
linked
to
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
cardiovascular
(CVD),
and
mortality.
However,
the
prognostic
utility
of
TyG-related
indices
in
predicting
risk
CVD
mortality
among
patients
with
MASLD
remains
unclear.
Data
97,331
patients,
a
median
age
58.0
years
free
at
baseline,
were
obtained
from
UK
Biobank.
The
TyG
index,
along
its
combination
adiposity
parameters
(i.e.
body
mass
index
[BMI],
waist
circumference
[WC],
waist-to-height
ratio
[WHtR]),
calculated.
Cox
proportional
hazards
models
restricted
cubic
spline
(RCS)
performed
evaluate
associations
between
overall
CVD,
coronary
heart
(CHD),
stroke,
all-cause
mortality,
Additionally,
Harrell's
C-index,
net
reclassification
(NRI),
integrated
discrimination
improvement
(IDI)
used
assess
predictive
performance
these
indices.
Over
follow-up
13.56
years,
we
identified
13,256
cases
10,980
CHD,
2,926
8,809
1,796
Compared
lowest
quartile
participants
high
had
significantly
increased
incident
Specifically,
hazard
ratios
occurring
fourth
versus
first
quartiles
1.19
(95%
confidence
interval:
1.13-1.25)
TyG,
1.35
(1.28-1.42)
TyG-BMI,
1.33
(1.26-1.40)
TyG-WC,
1.39
(1.32-1.46)
TyG-WHtR.
RCS
analyses
indicated
nonlinear
association
outcomes
(all
P
values
nonlinearity
<
0.05),
whereas
there
exhibited
linear
trends
TyG-WHtR
>
0.05,
except
TyG-WC
stroke).
Furthermore,
demonstrated
higher
NRI,
IDI
patients.
especially
TyG-WHtR,
significant
individuals
MASLD.
may
effective
surrogate
predictors
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Авг. 16, 2024
Insulin
resistance
is
linked
to
an
increased
risk
of
frailty,
yet
the
comprehensive
relationship
between
triglyceride
glucose-body
mass
index
(TyG-BMI),
which
reflects
weight,
and
remains
unclear.
This
investigated
in
this
study.
Data
from
9135
participants
China
Health
Retirement
Longitudinal
Study
(2011–2020)
were
analysed.
Baseline
TyG-BMI,
changes
TyG-BMI
cumulative
baseline
2015,
along
with
frailty
(FI)
over
nine
years,
calculated.
Participants
grouped
into
different
categories
based
on
using
K-means
clustering.
FI
trajectories
assessed
a
group-based
trajectory
model.
Logistic
Cox
regression
models
used
analyse
associations
frail
incidence.
Nonlinear
relationships
explored
restricted
cubic
splines,
linear
mixed-effects
model
was
evaluate
development
speed.
Weighted
quantile
identify
primary
contributing
factors.
Four
classes
two
identified.
Individuals
third
(OR
=
1.25,
95%
CI:
1.10–1.42)
fourth
1.83,
1.61–2.09)
quartiles
those
consistently
second
highest
1.49,
1.32–1.70)
2.17,
1.84–2.56)
changes,
1.20,
1.05–1.36)
1.94,
1.70–2.22)
had
greater
odds
experiencing
rapid
trajectory.
Higher
noted
quartile
(HR
1.42,
1.28–1.58),
1.23,
1.12–1.34)
1.58,
1.42–1.77),
1.10,
1.00-1.21)
1.46,
1.33–1.60).
persistently
second-lowest
(β
0.15,
0.38
0.76
respectively)
0.25
0.56,
demonstrated
accelerated
progression.
A
U-shaped
association
observed
levels
both
higher
risk,
BMI
being
factor.
associated
risk.
However,
excessively
low
also
appear
contribute
development.
Maintaining
healthy
especially
BMI,
may
help
prevent
or
delay
onset.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 2, 2025
The
triglyceride
glucose
(TyG)
index-related
obesity
indices
have
been
proposed
as
reliable
indicators
of
insulin
resistance.
This
study
aims
to
investigate
the
association
between
TyG
and
sarcopenia
well
their
potential
a
tool
for
screening
sarcopenic
patients.
A
cross-sectional
was
conducted
involving
7,161
participants
aged
18
above
from
National
Health
Nutrition
Examination
Survey.
index
indices,
including
glucose-body
mass
(TyG-BMI),
glucose-waist
circumference
(TyG-WC),
glucose-waist-to-height
ratio
(TyG-WHtR)
were
determined
using
standard
formulas.
appendicular
skeletal
muscle
BMI
used
assess
sarcopenia.
relationship
investigated
restricted
cubic
spline
analysis
multivariate
logistic
regression
analysis.
diagnostic
value
-related
compared
receiver
operating
characteristic
(ROC)
curve.
In
fully
adjusted
model,
positive
correlation
observed
TyG-WHtR
(for
each
one-unit
increase
in
index:
OR
=
3.57,
95%
CI:
2.71–4.71,
P
<
0.001).
Additionally,
analyses
demonstrated
significant
predictor
with
highest
odds
ratio,
reaching
12.50
(95%
6.13–25.70,
0.001)
upper
fourth
quartile
(Q4)
first
quartile,
followed
by
TyG-BMI
(Q4:
3.34;
1.92–5.80,
TyG-WC
1.95;
1.04–3.68,
RCS
curve
fitting
indicated
U-shaped
diagnosis
sarcopenia,
an
inflection
point
at
4.02.
Furthermore,
ROC
analysis,
AUC
largest
(0.79,
ndex-related
especially
TyG-WHtR,
shown
be
more
effective
identifying
patients
than
alone.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 10, 2025
Abstract
Insulin
resistance
(IR)
and
abdominal
obesity
are
key
in
osteoarthritis
(OA)
development.
The
triglyceride
glucose
(TyG)
index,
along
with
indicators
such
as
the
visceral
adiposity
index
(VAI),
lipid
accumulation
product
(LAP),
increasingly
used
to
measure
IR.
This
study
aims
explore
associations
between
surrogate
IR
indexes
OA,
assessing
their
diagnostic
efficacy
within
American
populations.
included
14,715
adults
from
National
Health
Nutrition
Examination
Survey
2003–2016.
Logistic
regression
models
restricted
cubic
spline
were
relationship
OA.
Receiver
operating
characteristic
curves
constructed
assess
of
these
indices,
area
under
curve
(AUC)
metric.
TyG,
triglyceride-waist
circumference
(TyG-WC),
triglyceride-body
mass
(TyG-BMI),
height
ratio
(TyG-WHtR),
VAI
LAP
significantly
positively
associated
prevalence
OA
(all
p
<
0.01).
After
adjusting
for
various
potential
confounders,
TyG-WC,
TyG-BMI,
TyG-WHtR
remained
correlated
Furthermore,
revealed
a
nonlinear
association
P
-non-linear
0.05).
indicated
that
(AUC
0.633)
demonstrated
more
robust
efficacy.
Additionally,
sensitivity
analysis
produced
results
consistent
primary
findings.
TyG
its
combination
LAP,
showing
highest
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
Triglyceride-glucose
(TyG)
related
indices,
which
serve
as
simple
markers
for
insulin
resistance,
have
been
closely
linked
to
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
cardiovascular
(CVD),
and
mortality.
However,
the
prognostic
utility
of
TyG-related
indices
in
predicting
risk
CVD
mortality
among
patients
with
MASLD
remains
unclear.
Data
97,331
patients,
a
median
age
58.0
years
free
at
baseline,
were
obtained
from
UK
Biobank.
The
TyG
index,
along
its
combination
adiposity
parameters
(i.e.
body
mass
index
[BMI],
waist
circumference
[WC],
waist-to-height
ratio
[WHtR]),
calculated.
Cox
proportional
hazards
models
restricted
cubic
spline
(RCS)
performed
evaluate
associations
between
overall
CVD,
coronary
heart
(CHD),
stroke,
all-cause
mortality,
Additionally,
Harrell's
C-index,
net
reclassification
(NRI),
integrated
discrimination
improvement
(IDI)
used
assess
predictive
performance
these
indices.
Over
follow-up
13.56
years,
we
identified
13,256
cases
10,980
CHD,
2,926
8,809
1,796
Compared
lowest
quartile
participants
high
had
significantly
increased
incident
Specifically,
hazard
ratios
occurring
fourth
versus
first
quartiles
1.19
(95%
confidence
interval:
1.13-1.25)
TyG,
1.35
(1.28-1.42)
TyG-BMI,
1.33
(1.26-1.40)
TyG-WC,
1.39
(1.32-1.46)
TyG-WHtR.
RCS
analyses
indicated
nonlinear
association
outcomes
(all
P
values
nonlinearity
<
0.05),
whereas
there
exhibited
linear
trends
TyG-WHtR
>
0.05,
except
TyG-WC
stroke).
Furthermore,
demonstrated
higher
NRI,
IDI
patients.
especially
TyG-WHtR,
significant
individuals
MASLD.
may
effective
surrogate
predictors
