Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis
Redox Biology,
Год журнала:
2024,
Номер
76, С. 103321 - 103321
Опубликована: Авг. 19, 2024
Cell
death
constitutes
a
critical
component
of
the
pathophysiology
cardiovascular
diseases.
A
growing
array
non-apoptotic
forms
regulated
cell
(RCD)-such
as
necroptosis,
ferroptosis,
pyroptosis,
and
cuproptosis-has
been
identified
is
intimately
linked
to
various
conditions.
These
RCD
are
governed
by
genetically
programmed
mechanisms
within
cell,
with
epigenetic
modifications
being
common
crucial
regulatory
method.
Such
include
DNA
methylation,
RNA
histone
acetylation,
non-coding
RNAs.
This
review
recaps
roles
modifications,
RNAs
in
diseases,
well
which
regulate
key
proteins
involved
death.
Furthermore,
we
systematically
catalog
existing
pharmacological
agents
targeting
novel
their
action
article
aims
underscore
pivotal
role
precisely
regulating
specific
pathways
thus
offering
potential
new
therapeutic
avenues
that
may
prove
more
effective
safer
than
traditional
treatments.
Язык: Английский
Dyslipidemia-induced renal fibrosis related to ferroptosis and endoplasmic reticulum stress
Journal of Lipid Research,
Год журнала:
2024,
Номер
65(9), С. 100610 - 100610
Опубликована: Июль 31, 2024
Dyslipidemia
may
induce
chronic
kidney
disease
and
trigger
both
ferroptosis
endoplasmic
reticulum
(ER)
stress,
but
the
instigating
factors
are
incompletely
understood.
We
tested
hypothesis
that
different
models
of
dyslipidemia
engage
distinct
injury
mechanisms.
Wild-type
(WT)
or
proprotein-convertase
subtilisin/kexin
type-9
(PCSK9)-gain-of-function
(GOF)
Ossabaw
pigs
were
fed
with
a
6-month
normal
diet
(ND)
high-fat
(HFD)
(n
=
5-6
each).
Renal
function
fat
deposition
studied
in
vivo
using
CT,
blood
tissue
ex-vivo
for
lipid
profile,
systemic
renal
vein
FFAs
levels,
mechanisms
including
peroxidation,
ferroptosis,
ER
stress.
Compared
WT-ND
pigs,
HFD
PCSK9-GOF
elevated
triglyceride
which
highest
WT-HFD,
whereas
total
LDL
cholesterol
levels
rose
only
particularly
PCSK9-GOF/HFD.
The
groups
had
worse
than
ND
groups.
WT-HFD
kidneys
retained
more
FFA
other
groups,
all
developed
fibrosis.
Furthermore,
HFD-induced
indicated
by
increased
free
iron,
decreased
glutathione
peroxidase-4
mRNA
expression,
while
induced
stress
upregulated
GRP94
CHOP
protein
expression.
In
vitro,
pig
epithelial
cells
treated
palmitic
acid
oxidized
to
mimic
showed
similar
trends
those
observed
vivo.
Taken
together,
hypertriglyceridemia
promotes
retention
PCSK9-GOF-induced
hypercholesterolemia
elicits
resulting
These
observations
suggest
targets
preventing
treating
fibrosis
subjects
specific
types
dyslipidemia.
Язык: Английский
ROS-mediated ferroptosis and pyroptosis in cardiomyocytes: An update
Life Sciences,
Год журнала:
2025,
Номер
unknown, С. 123565 - 123565
Опубликована: Март 1, 2025
Язык: Английский
Profiling and bioinformatics analyses of circular RNAs in myocardial ischemia/reperfusion injury model in mice
World Journal of Cardiology,
Год журнала:
2025,
Номер
17(1)
Опубликована: Янв. 21, 2025
BACKGROUND
Myocardial
ischemia/reperfusion
(I/R)
injury,
which
is
associated
with
high
morbidity
and
mortality,
a
main
cause
of
unexpected
myocardial
injury
after
acute
infarction.
However,
the
underlying
mechanism
remains
unclear.
Circular
RNAs
(circRNAs),
are
formed
from
protein-coding
genes,
can
sequester
microRNAs
or
proteins,
modulate
transcription
interfere
splicing.
Authoritative
studies
suggest
that
circRNAs
may
play
an
important
role
in
I/R
injury.
AIM
To
explore
METHODS
We
constructed
model
using
ligation
left
anterior
descending
coronary
artery,
evaluated
success
validated
triphenyltetrazolium
chloride
hematoxylin-eosin
staining.
Then,
ventricular
samples
different
groups
were
selected
for
mRNA-sequence,
differential
gene
screening
was
performed
on
obtained
results.
The
differentially
mRNAs
divided
into
up-regulated
down-regulated
according
to
their
expression
levels,
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
functional
enrichment
analysis
performed,
respectively.
circRNA
microRNA
(miRNA)
paired
analysis,
binding
sites
miRNA
mRNA
virtual
screened.
Finally,
circRNA,
by
ceRNA
mutual
most
useful
network.
RESULTS
used
RNA
sequencing
array
investigate
signatures
three
group
sham
group.
A
total
142
upregulated
121
downregulated
found
be
expressed
(fold
change
≥
2,
P
<
0.05).
GO
KEGG
analyses
these
performed.
revealed
involved
mainly
cellular
intracellular
processes.
demonstrated
6
top
20
pathways
correlated
cell
apoptosis.
Furthermore,
circRNA-miRNA
coexpression
network
based
genes
constructed,
revealing
mmu-circ-0001452,
mmu-circ-0001637,
mmu-circ-0000870
might
key
regulators
CONCLUSION
This
research
provides
new
insights
I/R,
expected
therapeutic
targets
Язык: Английский
Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 7, 2025
Cardiovascular
diseases
represent
the
principal
cause
of
death
and
comorbidity
among
people
with
diabetes.
Ferroptosis,
an
iron-dependent
non-apoptotic
regulated
cellular
characterized
by
lipid
peroxidation,
is
involved
in
pathogenesis
diabetic
cardiovascular
diseases.
The
susceptibility
to
ferroptosis
hearts
possibly
related
myocardial
iron
accumulation,
abnormal
metabolism
excess
oxidative
stress
under
hyperglycemia
conditions.
Accumulating
evidence
suggests
can
be
therapeutic
target
for
This
review
summarizes
ferroptosis-related
mechanisms
novel
choices
targeting
pathways.
Further
study
on
ferroptosis-mediated
cardiac
injury
enhance
our
understanding
pathophysiology
provide
more
potential
choices.
Язык: Английский
The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2025,
Номер
unknown, С. 167797 - 167797
Опубликована: Март 1, 2025
Язык: Английский
Ferroptosis at the nexus of metabolism and metabolic diseases
Theranostics,
Год журнала:
2024,
Номер
14(15), С. 5826 - 5852
Опубликована: Янв. 1, 2024
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death,
is
emerging
as
a
crucial
regulator
human
physiology
and
pathology.
Increasing
evidence
showcases
reciprocal
relationship
between
ferroptosis
dysregulated
metabolism,
propagating
pathogenic
vicious
cycle
that
exacerbates
pathology
diseases,
particularly
metabolic
disorders.
Consequently,
there
rapidly
growing
interest
in
developing
ferroptosis-based
therapeutics.
Therefore,
comprehensive
understanding
the
intricate
interplay
metabolism
could
provide
invaluable
resource
for
mechanistic
insight
therapeutic
development.
In
this
review,
we
summarize
important
substances
associated
pathways
initiation
progression,
outline
cascade
responses
disease
development,
overview
roles
mechanisms
introduce
methods
detection,
discuss
perspectives
ferroptosis,
which
collectively
aim
to
illustrate
view
basic,
translational,
clinical
science.
Язык: Английский