The additive effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with and without diabetes: a population-based study

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 22, 2024

The triglyceride-glucose (TyG) index and estimated glucose disposal rate (eGDR), which are calculated using different parameters, widely used as markers of insulin resistance associated with cardiovascular diseases prognosis. However, whether they have an additive effect on the risk mortality remains unclear. This study aimed to explore combined assessment TyG eGDR improved prediction long-term in individuals without diabetes. In this cross-sectional cohort study, data were derived from National Health Nutrition Examination Survey (NHANES) 2001–2018, death record information was obtained Death Index. associations all-cause determined by multivariate Cox regression analysis restricted cubic splines. Among 17,787 included analysis, there 1946 (10.9%) deaths 649 (3.6%) during a median follow-up 8.92 years. diabetes, spline curves for followed J-shape L-shape, respectively. significantly increased after > 9.04 (all-cause mortality) or 9.30 (cardiovascular mortality), < 4 mg/kg/min (both mortality). association between negative linear relationship. no mortality. Compared low high group, those group (TyG 4) showed highest (hazard ratio [HR] = 1.592, 95% confidence interval [CI] 1.284–1.975) (HR 1.683, CI 1.179-2.400) overall population. Similar results observed There potential provided additional prognostic contributed improving stratification.

Язык: Английский

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Associations of dietary inflammation index and composite dietary antioxidant index with preserved ratio impaired spirometry in US adults and the mediating roles of triglyceride-glucose index: NHANES 2007–2012

Redox Biology, Год журнала: 2024, Номер 76, С. 103334 - 103334

Опубликована: Авг. 30, 2024

Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few examined association these diets with its early signs (PRISm), potential role metabolic disorders remains to be elucidated.

Язык: Английский

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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 7, 2025

Insulin resistance, represented by increased triglyceride-glucose (TyG) index levels, shows interplay with visceral obesity and together promotes cardiovascular diseases mortality. However, significant controversies exist regarding whether modified TyG indices, such as TyG-BMI, TyG-WC, TyG-WHtR, outperform the in predicting outcomes. We aimed to explore there was a synergistic effect of body shape (ABSI), better parameter reflecting obesity, on analyzed data from National Health Nutrition Examination Survey (NHANES) 2001-2018 17,329 individuals. The associations ABSI mortality were investigated via Cox regression analysis restricted cubic splines. Receiver operating characteristic (ROC) curve performed compare predictive value. Mediation used potential mediator. A total 673 (3.9%) deaths occurred during median follow-up 8.92 years. Individuals high (TyG > 9.04 0.085) at highest risk both individuals (HR = 1.714, 95% CI 1.123-2.616) without diabetes 1.402, 1.003-1.960), suggesting effect. Next, we multiplied these two indicators established TyG-ABSI. It showed J-shaped relationship positive linear diabetes, respectively. Arterial stiffness, estimated pulse wave velocity, partially mediated TyG-ABSI mortality, mediation proportion 42.7%. value greater than that index, TyG-WHtR (Harrell's C-index: 0.710 vs 0.623 0.539 0.612 0.622, all p < 0.001). simultaneous assessment revealed recommended use instead other indices assessment.

Язык: Английский

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Association between the cumulative estimated glucose disposal rate and incident cardiovascular disease in individuals over the age of 50 years and without diabetes: data from two large cohorts in China and the United States

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 31, 2025

The estimated glucose disposal rate (eGDR) has been linked to incident cardiovascular disease (CVD) in individuals without diabetes. However, few studies have accounted for long-term cumulative eGDR exposure. aim of this study was explore whether independently associated with CVD over the age 50 years and This used data from China Health Retirement Longitudinal Study (CHARLS) (HRS). calculated as summation average each pair consecutive examinations multiplied by time between these two visits, years. outcome CVD. Cox proportional hazards regression models restricted cubic spline (RCS) were evaluate association A total 2430 participants CHARLS 2008 HRS included analysis. median at baseline 59 [IQR: 55-65 years], 1205 (49.59%) men. 64 57-70 705 (35.11%) RCS model showed a negative linear incidence (CHARLS: P < 0.001, nonlinearity = 0.248; HRS: 0.013, 0.121). After multivariate adjustment, higher levels lower risk (per SD, CHARLS: HR: 0.802, 95% CI: 0.716-0.898, 0.791, 0.665-0.940, pooled analysis: 0.799, 0.726-0.878). level an increased Continuous monitoring exposure time, based on consideration traditional factors, may prove beneficial early identification intervention high In regions limited healthcare resources, among ability access, process, understand health information services, offer improved clinical applicability.

Язык: Английский

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A retrospective study utilized MIMIC-IV database to explore the potential association between triglyceride-glucose index and mortality in critically ill patients with sepsis

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 15, 2024

Triglyceride-glucose (TyG) index has emerged as a novel biomarker for detecting insulin resistance (IR) and been proven to be associated with various diseases. However, its correlation the prognosis of severe sepsis remains unraveled. This retrospective cohort study utilized patient records from Medical Information Mart Intensive Care (MIMIC-IV, version 2.2) examine outcomes patients sepsis. The primary were hospital mortality intensive care unit (ICU) mortality. between TyG was evaluated through Kaplan-Meier method, Log-rank test, univariate multivariate Cox regression analyses. Additionally, restricted cubic spline (RCS) analysis employed delve into nonlinear relationship baseline outcomes, trend significance assessed quartile levels. Subgroup analyses conducted evaluate consistency index's prognostic value across influencing factors. included 1,742 requiring care. in-hospital rate 19.75% (344/1,742), ICU 14.75% (257/1,742). revealed that, in comparison first (Q1), fourth (Q4) had 63% higher risk (HR 1.63 [95% CI 1.22 2.18], P < 0.01) 79% 1.79 1.28 2.51], 0.001). Model 3 showed that risks Q4, Q3, Q2 240%, 75%, 33% higher, respectively 3.40 2.24 5.16], 0.001; HR 1.75 1.16 2.63], = 0.007; 1.33 1.20 1.53], RCS identified association (overall nonlinearity 0.001, an inflection point at 8.9). effect size direction consistent different subgroups, suggesting stability results. demonstrates is significantly increased critically ill patients, evidence non-linear correlation. Therefore, helps identify ICU.

Язык: Английский

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Positive association of triglyceride glucose index and gestational diabetes mellitus: a retrospective cohort study

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Gestational diabetes mellitus (GDM) is a common metabolic disorder with important health implications for both mother and offspring. This study aims to assess the relationship between Triglyceride Glucose (TyG) index GDM explore its clinical significance. A retrospective cohort included 631 singleton pregnant women. The collected data on TyG index, glucose levels, outcomes from all participants. Research objectives were validated using logistic regression analysis Receiver Operating Characteristic curves. We found an independent correlation increased risk of GDM, odds ratio (OR) 3.11 (95% confidence interval (CI): 2.09-4.63, P<0.001). spline model revealed linear association in early pregnancy (non-linear P=0.748), increase index. In addition, we that has high diagnostic performance predicting AUC value 0.668. Combined Age, it can improve predictive performance, 0.684. Compared lower quartile women higher have incidence premature birth, hypertensive disorders pregnancy, intrahepatic cholestasis (ICP). group, was negatively correlated 25 (OH) D TBIL, positively FBG, TG, TC. strongly linked development factor it. Monitoring levels valuable identifying at GDM.

Язык: Английский

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The triglyceride glucose index and delirium risk in sepsis patients: A causal inference study

Nursing in Critical Care, Год журнала: 2025, Номер 30(2)

Опубликована: Фев. 26, 2025

Abstract Background Sepsis, a grave systemic infection, presents substantial health challenges. While insulin resistance frequently occurs in sepsis conditions, its relationship with sepsis‐associated delirium remains insufficiently explored. Aim This study aimed to explore the causal effect between triglyceride glucose (TyG) index and risk of patients through use inference. Study Design A cohort 5461 admitted intensive care unit (ICU) was selected from Medical Information Mart for Intensive Care IV database. Patients were grouped into high TyG (≥9.48) low (<9.48) categories. Propensity score matching applied control confounders, average treatment on treated calculated. Results Of patients, 59.6% experienced delirium. The incidence higher group (1751 patients; 66.6%) than (56.3%) ( p < .001). results logistic regression analysis indicated that significantly (adjusted odds ratio 1.34, 95% confidence interval: 1.16–1.53). Following matching, increased by 6.9% T = 3.29), finding confirmed Rosenbaum sensitivity analysis. Conclusions represents straightforward efficacious instrument nursing staff ascertain likelihood during routine monitoring their condition. ability make inferences observational studies provides novel approach research. Relevance Clinical Practice readily applicable ICU nurses identify patients. enables possibility early intervention high‐risk individuals optimization outcomes.

Язык: Английский

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Elevated Triglyceride-Glucose Index as a Risk Stratification Marker for Diabetic Retinopathy in Type 2 Diabetes Mellitus: The Influence of Glycemic Control

Diabetes Metabolic Syndrome and Obesity, Год журнала: 2025, Номер Volume 18, С. 743 - 759

Опубликована: Март 1, 2025

Background: Diabetic retinopathy (DR) is a common microvascular complication observed in people with type 2 diabetes mellitus (T2DM). The triglyceride-glucose (TyG) index, an indicator of insulin resistance, has uncertain role glycemic management T2DM patients at risk for DR. This study aimed to evaluate the association between TyG index and DR across different control status. Methods: A total 4,372 in-patients from Beijing Tongren Hospital (2013– 2024) were included this study. categorized into four groups based on quartiles (Q1-Q4). Participants stratified by (Q1-Q4) status (HbA1c < 7%, 7– 9%, > 9%). Restricted cubic spline (RCS) analysis, logistic regression, subgroup analyses employed explore associations among risk. Results: Overall, there positive highest Q4 was significantly associated increased (odds ratio [OR]: 1.289; 95% confidence interval [CI]: 1.008– 1.648, P 0.05), compared lowest Q1. Significant interaction ( 0.05). Notably, strongest HbA1c 9%. Conclusion: relationship high more pronounced 9% group, indicating that may serve as useful tool making stratification patients. Keywords: retinopathy, control, glycated hemoglobin A1c,

Язык: Английский

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Triglyceride-glucose index is independently associated with fatty pancreas disease in Chinese elderly

BMC Endocrine Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Март 18, 2025

To determine the prevalence of fatty pancreas disease (FPD) diagnosed by transabdominal ultrasound in Chinese elderly aged 65 years and above to explore correlation between triglyceride glucose index (TyG index) FPD its severity, evaluate ability TyG identify severity. The study population was derived from Thyroid Diseases Older Population: Screening, Surveillance, Intervention (TOPS) conducted iodine-adapted areas Jiangsu Province May July 2021. A total 567 participants rural were included final analysis. calculated established formula: Ln [TG (mg/dL) × FBG (mg/dL)/2]. degree intra-pancreatic fat deposition (IPFD) abdominal ultrasound. logistic regression model performed clinical parameters, including index, diagnostic power assessed receiver operating characteristic curve (ROC). Overall, 72.66% (412/567) subjects had FPD, which over half moderate severe FPD. proportions overweight, obesity, NAFLD, dyslipidemia significantly higher moderate-to-severe group than mild group. Multivariate showed that independently associated with population, but not severity IPFD. As level increased, metabolic disorders worsened increased significantly. a good performance for combination BMI or NAFLD improved is high China. has identification poor recognition when combined other may have more advantages.

Язык: Английский

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Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 24, 2025

The triglyceride–glucose (TyG) index, an emerging surrogate marker of insulin resistance, has been implicated in adverse cardiovascular outcomes. However, its prognostic value critically ill patients with atrial fibrillation (AF) remains unclear. This study aimed to investigate the association between TyG index and all-cause mortality this high-risk population. We identified AF from Medical Information Mart for Intensive Care IV (MIMIC-IV) database categorized them into tertiles based on their levels. primary outcome was 30-day mortality, 90-day 365-day as secondary Cox proportional hazards regression analysis restricted cubic splines were used elucidate relationship mortality. Kaplan–Meier survival performed visualize differences among tertiles. A total 1473 included; 30-day, 90-day, rates 26.8%, 33.3%, 41.1%, respectively. Multivariate revealed that independently associated at 30 days [hazard ratio (HR) (95% confidence interval (CI)) 1.26 (1.09–1.45), P = 0.002], 90 [HR CI) 1.27 (1.11–1.45), < 0.001], 365 1.24 (1.10–1.40), 0.001]. Restricted showed a positive linear risk. curves further confirmed significant disparities across observed higher increased 30, 90, AF. underscores role key indicator risk stratification management intensive care.

Язык: Английский

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