Correlation between atherogenic index of plasma and cardiovascular disease risk across Cardiovascular–kidney–metabolic syndrome stages 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

The Cardiovascular-kidney-metabolic (CKM) syndrome, a concept recently proposed by the American Heart Association (AHA), highlights intricate connection between metabolic, renal, and cardiovascular illnesses. Furthermore, Atherogenic Index of Plasma (AIP), useful biomarker for evaluating risk Cardiovascular Diseases (CVDs), has been associated with Adverse Events (ACEs). Nonetheless, its precise function in populations CKM syndrome Stages 0-3 remains unknown. This prospective study analyzed data 7,708 eligible participants (aged ≥ 45 years) from Chinese Longitudinal Research Ageing (CHARLS), particularly 2011-2012 baseline survey (Wave 1). primary exposure variable was AIP-a natural logarithm ratio Triglycerides (TGs) to High-Density Lipoprotein Cholesterol (HDL-C). On other hand, endpoint CVD incidence, which determined based on self-reported past diagnoses. relationship AIP population stages examined using Cox proportional model. Subgroup mediation analyses were performed further elucidate interactions among these factors. involved [Mean age = 58.00 years; Interquartile Range (IQR) 52.00-65.00 years]. developing increased significantly higher levels. Specifically, each unit increase 1.31 (95% CI 1.11-1.55), while Hazard Ratio (HR) group highest levels compared lowest 1.22 1.08-1.39). Mediation analysis revealed that metabolic accounted 12.3% association (p 0.024), highlighting significance assessment. Herein, correlated positively individuals 0-3, as key mediating factor. These findings suggest could be valuable not only assessment but also clinical screening.

Язык: Английский

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The triglyceride–glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 29, 2025

Язык: Английский

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Association between solid cooking fuels exposure and metabolic syndrome: Evidence from China

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117648 - 117648

Опубликована: Янв. 1, 2025

Epidemiological evidence connecting cooking fuel use to metabolic syndrome (MetS) is lacking. Solid usage and MetS prevalence were prospectively investigated in this study. We included participants 2011 2015 from the China Health Retirement Longitudinal Study (CHARLS) data. Through cross-sectional longitudinal studies, we found that of solid fuels reduced risk compared with clean (cross-sectional study: 2011: Odds ratio (OR): 0.819, 95 %confidence interval (CI): 0.747-0.897, P < 0.001; 2015: OR: 0.766, %CI: 0.708-0.851, 0.736, 0.652-0.831, 0.001).This impact ceases exist whenever a switch type occurs (Non persistent clean: 0.937, 0.837-1.050, = 0.262; Persistent solid: 0.767, 0.691-0.853, 0.001). Moreover, biomass (crop residue wood burning) combustion (OR: 0.653, 0.573-0.743, 0.001), while coal had no effect on 1.092, 0.907-1.315, 0.352). Based mediation analysis, triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) mediated 61.3 % 39.8 reduction observed fuel. In summary, our research showed household associated less risk. Among them, may play an important role.

Язык: Английский

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Atherogenic index of plasma and cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stage 1 to 3: a longitudinal study

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

Background Cardiovascular disease (CVD) remains a major contributor to the global burden. Previous studies have established link between atherogenic index of plasma (AIP) and CVD. However, it unclear whether cumulative AIP control influence future incidence CVD in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome. This study aims explore association AIP, levels, risk CKM syndrome from stages 1 3. Methods Participants were drawn China Health Retirement Longitudinal Study (CHARLS). Cumulative was calculated using triglycerides (TG) high-density lipoprotein cholesterol (HDL-C), while levels categorized into four groups via k-means clustering. defined by self-reported heart or stroke. Multivariable logistic regression restricted cubic spline analysis employed examine incident Results A total 793 participants (18.84%) developed After adjusting for confounders, associated developing (OR=1.139, 95% CI: 1.017-1.275, P=0.0245). Compared group (best control), OR (95% CI) 1.278 (0.959-1.702) 2, 1.329 (1.076-1.641) 3, 1.195 (0.974-1.465) 4. Restricted indicated relationship is linear (P nonlinear = 0.3377). Conclusions In middle-aged elderly syndrome, higher poorer an elevated These findings suggest that enhanced assessment could inform targeted prevention strategies context

Язык: Английский

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Comparison of triglyceride glucose index and modified triglyceride glucose indices in predicting cardiovascular diseases incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 28, 2025

Cardiovascular-kidney-metabolic (CKM) syndrome has been recently proposed by American Heart Association recently. The triglyceride glucose (TyG) index and TyG-related indices combined with obesity indicators have proven to be associated the incidence of cardiovascular diseases (CVD). However, there are few studies explore whether these associations exist among people CKM stages 0–3. A total 7,364 participants from China Health Retirement Longitudinal Study were included. Cox hazard regression restricted cubic spline used analyze CVD incidence. To compare predictive performance, time-dependent Harrell's C-indices, net reclassification integrated discrimination improvement conducted. was 20.55% over nine years. TyG single all modified capable predicting RCS analyses showed that had linear relationships waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still existed in stage 1, 2 3. TyG-WC (C-index: 0.621, p < 0.001) TyG-WHtR almost highest C-indices incidence, compared 0.611, body mass 0.616, 0.001). independent predictors It found better especially ratio.

Язык: Английский

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Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 28, 2025

The triglyceride glucose-body mass index (TyG-BMI) has been established as a convenient and reliable marker for assessing insulin resistance (IR) shown to be significantly correlated with stroke. However, only few studies have conducted in this field, conflicting conclusions. This study based on the eICU database, investigated association between TyG-BMI 28-day mortality critically ill ischemic stroke (IS) patients. Multivariate Cox regression models were employed analyze impacts of hospital ICU mortality. Restricted cubic splines (RCS) applied explore nonlinear relationship K‒M curves utilized outcome comparisons among different groups. Additionally, interaction subgroup analyses performed validate robustness results. A total 1,362 patients IS enrolled, mean age 68.41 ± 14.16 years; 47.50% male. analysis revealed that, high group had higher mortality(HR = 1.734, P 0.032) (HR 2.337, p 0.048). RCS showed positive correlation Below inflection point 380.37, each increase 1 standard deviation (SD) (approximately 25.5 units) was associated 37.3% 1.373, 0.015), above 380.376, 1-SD resulted an 87.9% decrease 0.121, 0.057). log-likelihood ratio test value 0.004. For mortality, exhibited significant linear RCS. Elevated is increased risk short-term all-cause United States. result provides compelling evidence address existing discrepancies research domain, indicating that could serve straightforward efficient biomarker identifying at

Язык: Английский

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Relationship between TyG-related index and hearing loss in people over 45 s in China

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 5, 2025

Background Triglycerides and fasting glycemic index are biomarkers used to assess the risk of insulin resistance metabolic syndrome. It its derivatives such as TyG-BMI currently able reflect degree closely related a variety diseases. The relationship between hearing loss remains underexplored, particularly in context aging public health. This study investigates association TyG index, BMI with loss, focus on their potential implications for population. Methods Data from China Health Retirement Longitudinal Study (CHARLS) database were analyzed using R software. We applied multi-factor logistic regression, linear restricted cubic splines, subgroup analyses impact across different age groups. Results was not significantly associated loss. However, both exhibited positive correlation among older individuals. results suggest that population ages, higher indices may increase impairment. Conclusion While does show significant link an increased especially adults. These findings highlight importance considering aging-related factors health initiatives aimed at preventing Further research is needed elucidate mechanisms underlying these associations develop age-inclusive strategies addressing impairment

Язык: Английский

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The negative correlation between triglyceride glucose‐body mass index and hormone levels in young and middle‐aged patients with clinical varicocoele: A cross‐sectional study

Andrology, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract Background Varicocoele may influence testosterone levels; however, their relationship remains controversial. Insulin resistance (IR) is a significant factor in metabolic disorders that affect sex hormone levels. Triglyceride glucose‐body mass index (TyG‐BMI) an important indicator of IR, but its with hormones patients varicocoele and clinical significance require further investigation. Objective To investigate whether different severity grades clinically palpable varicocoeles are associated changes This study also seeks to explore the association between TyG‐BMI evaluate effectiveness compared other IR indicators predicting deficiency. Materials methods cross‐sectional included 431 varicocoeles. was classified based on grading, color Doppler ultrasound reflux status. Additionally, categorized according interquartile ranges, linear regression analysis used examine hormones, along subgroup analysis. four indices were predict Results In young middle‐aged varicocoeles, levels did not differ significantly across varying degrees severity. negatively correlated testosterone, inhibin B (INHB), prolactin levels, particularly higher TyG‐BMI. However, no relationships found follicle‐stimulating hormone, luteinizing or estradiol The remained demonstrated superior predictive capability for deficiency indices. Discussion conclusion variations INHB this suggests beyond hypothalamic–pituitary–gonadal axis.

Язык: Английский

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Nonlinear relationships between the triglyceride glucose-body mass index and cardiovascular disease in middle-aged and elderly women from NHANES (1999–2018)

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 31, 2025

Abstract This study aims to investigate the relationship between triglyceride-glucose body mass index (TyG-BMI) and cardiovascular disease (CVD) among middle-aged elderly women, using data from National Health Nutrition Examination Survey (NHANES) spanning 1999 2018. TyG-BMI was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] BMI. After applying sampling weights NHANES, sample of 6,343 participants is representative approximately 59,174,898 American women. We categorized into quartiles, Q3 reference group. In crude model, Q4 exhibited a 40% increased odds CVD (odds ratio [OR] = 1.40, 95% confidence interval [CI] 1.09–1.79, P 0.009). fully adjusted for relative 39% (OR 1.39, CI 1.06–1.82, 0.019). Further analysis restricted cubic splines (RCS) threshold effect confirmed nonlinear them. Below 260, there no significant association with odds. However, above each 10-unit increase in associated 2.4% this demographic. Sensitivity analyses stability results.

Язык: Английский

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Association between admission serum calcium levels and in‑hospital mortality in acute myocardial infarction patients with cardiovascular-kidney-metabolic syndrome

Endocrine, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

Acute myocardial infarction (AMI) with cardiovascular-kidney-metabolic (CKM) condition is linked to a high in-hospital mortality. Some previous studies reported that calcium may be related mortality among patients AMI. However, there no report about the association between serum and AMI CKM syndrome. Therefore, this study investigated admission levels in cohort of This retrospective enrolled 2537 admitted including 270 CKM. All data were extracted from electronic medical records May 2019 April 2024. According reference range calcium, all divided into two groups, low group (0-2.10 mmol/L) non-low (from 2.11 mmol/L). The primary endpoint was rate significantly higher (16.8%, n = 19) compared (8.3%, 13). After adjusting for age, gender, hypertension, atrial fibrillation, stroke smoke, demonstrated (OR 2.409, 95% CI: 1.105-5.249, p < 0.05). In subgroup analyses, multivariable logistic regression models indicated an independent predictor females 7.453; CI 1.751-31.730; 0.05) elderly 3.122; 1.167-8.348; after adjustments smoke. Restricted cubic splines (RCS) analysis showed dose-response relationship (nonlinear P value 0.067). Admission hypocalcemia risk factor syndrome, especially individuals (aged ≥76 years) females.

Язык: Английский

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