Metabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System

Trends in Cardiovascular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

Triglyceride-glucose (TyG) related indices, which serve as simple markers for insulin resistance, have been closely linked to metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular (CVD), and mortality. However, the prognostic utility of TyG-related indices in predicting risk CVD mortality among patients with MASLD remains unclear. Data 97,331 patients, a median age 58.0 years free at baseline, were obtained from UK Biobank. The TyG index, along its combination adiposity parameters (i.e. body mass index [BMI], waist circumference [WC], waist-to-height ratio [WHtR]), calculated. Cox proportional hazards models restricted cubic spline (RCS) performed evaluate associations between overall CVD, coronary heart (CHD), stroke, all-cause mortality, Additionally, Harrell's C-index, net reclassification (NRI), integrated discrimination improvement (IDI) used assess predictive performance these indices. Over follow-up 13.56 years, we identified 13,256 cases 10,980 CHD, 2,926 8,809 1,796 Compared lowest quartile participants high had significantly increased incident Specifically, hazard ratios occurring fourth versus first quartiles 1.19 (95% confidence interval: 1.13-1.25) TyG, 1.35 (1.28-1.42) TyG-BMI, 1.33 (1.26-1.40) TyG-WC, 1.39 (1.32-1.46) TyG-WHtR. RCS analyses indicated nonlinear association outcomes (all P values nonlinearity < 0.05), whereas there exhibited linear trends TyG-WHtR > 0.05, except TyG-WC stroke). Furthermore, demonstrated higher NRI, IDI patients. especially TyG-WHtR, significant individuals MASLD. may effective surrogate predictors

Язык: Английский

---

Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study

Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)

Опубликована: Янв. 13, 2025

Evidence concerning the effect of cardiovascular health (CVH) on risk metabolic dysfunctional-associated steatotic liver disease (MASLD) is scarce. This study aimed to investigate association between CVH and MASLD. 5680 adults aged ≥ 20 years from National Health Nutrition Examination Survey 2017-March 2020 were included. Life's essential 8 (LE8) was applied assess CVH. Weighted binary logistic regression employed calculate odds ratio (OR) 95% confidence interval (CI) with Restricted cubic spline (RCS) conducted explore dose-response LE8 its subscales scores Among participants, 724, 3901, 1055 had low, moderate, high levels, respectively, a MASLD diagnosis prevalence 36.83%. In fully adjusted model, ORs for 0.50 (95% CI, 0.37–0.69) participants moderate 0.21 0.13–0.34) those CVH, when compared low (P < 0.001 trend). OR 0.68 0.61–0.77) each 10-point increase in score. RCS model demonstrated non-linear relationship score factors MASLD, while linear found behaviors Subgroup analysis showed consistent negative correlation sensitivity validated reliability these findings. Higher associated lower Encouraging adherence optimal levels may help mitigate burden

Язык: Английский

---

Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 7, 2025

Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular characterized by lipid peroxidation, is involved in pathogenesis diabetic cardiovascular diseases. The susceptibility to ferroptosis hearts possibly related myocardial iron accumulation, abnormal metabolism excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests can be therapeutic target for This review summarizes ferroptosis-related mechanisms novel choices targeting pathways. Further study on ferroptosis-mediated cardiac injury enhance our understanding pathophysiology provide more potential choices.

Язык: Английский

---

LncRNA A2ml2 inhibits fatty liver hemorrhage syndrome progression and function as ceRNA to target LPL by sponging miR-143-5p

Poultry Science, Год журнала: 2025, Номер 104(5), С. 105003 - 105003

Опубликована: Март 7, 2025

Fatty liver hemorrhage syndrome (FLHS) is the most common metabolic diseases in laying hens during late-laying period, and it causes a significant economic burden on poultry industry. The competing endogenous RNA plays crucial roles occurrence development of fatty liver. Based previously constructed lncRNA-miRNA-mRNA networks, we selected axis ENSGALT00000079786-LPL-miR-143-5p for further study to elucidate its mechanistic role In this study, identified novel highly conserved lncRNA (ENSGALT00000079786) poultry, which designated as A2ml2 based chromosomal location. Fluorescent situ hybridization (FISH) revealed that was localized both nucleus cytoplasm. Dual-luciferase reporter assay validated targeted relationship between A2ml2, miR-143-5p, LPL gene. To analyze miR-143-5p function, overexpression vector successfully transfected into Leghorn male hepatocellular (LMH) cells, could remarkably inhibit cellular lipid deposition detected by oil red staining (P < 0.01), opposite occurred 0.01). qPCR demonstrated an inverse correlation expression expression, confirmed directly target A2ml2. Similarly, found miR-143-5p. investigate interactions among these three factors their effects metabolism, assessed levels co-transfecting with mimic binding site mutants. Co-transfection experiments showed diminished promoting effect LPL. Meanwhile, has capacity mitigate suppressive impact accumulation LMH cells. results attenuated hepatic through negatively regulating enhancing Our findings offer insights ceRNA-mediated FLHS identify potential molecular biomarker.

Язык: Английский

---

Noninvasive Assessment of the Severity of Liver Fibrosis in MASLD Patients with Long-Standing Type 2 Diabetes

Journal of General Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Background Type 2 diabetes mellitus (T2DM) and metabolic dysfunction–associated steatotic liver disease (MASLD), which have a reciprocal relationship compounded by obesity, are highly prevalent in the Middle East affecting morbidity, mortality, healthcare costs. Objective This study aimed to assess severity of MASLD fibrosis among adult Emirati patients with long-standing T2DM. Design Participants cross-sectional used noninvasive methods progression an cohort ( N = 546) mean T2DM duration 16 years. Main Measures Fatty infiltration was assessed hepatic steatosis index (HSI), while fibrosis-4 (FIB-4) aspartate aminotransferase/platelet ratio (APRI). Of those, 108 were randomly subjected ultrasound-based FibroScan ® controlled attenuation parameter (CAP) stiffness measurement (LSM). Key Results All had fatty ~ 83% being categorized as having severe steatosis. Serum-based biomarker panels detected significant 2.5% these patients. The APRI appeared be more restrictive detecting moderate (1.5%) than FIB-4 (25.5%). CAP significantly correlated LSM, indicating that two contributed same underlying pathophysiology. Liver female patients, who older higher body mass (BMI) those or no fibrosis. They also serum enzymes likely age-related changes kidney function. Interestingly, both remained unaffected age T2D except for . Conclusions highlights critical need routine screening T2DM, given high point prevalence (~ 83%), predominantly women this population.

Язык: Английский

---

Metabolic Dysfunction-Associated Steatotic Liver Disease: Pathogenetic Links to Cardiovascular Risk

Biomolecules, Год журнала: 2025, Номер 15(2), С. 163 - 163

Опубликована: Янв. 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is correlated with an increased cardiovascular risk, independent of other traditional risk factors. The mechanisms underlying this pathogenic link are complex yet remain incompletely elucidated. Among these, the most significant visceral adiposity, low-grade inflammation and oxidative stress, endothelial dysfunction, prothrombotic status, insulin resistance, dyslipidemia postprandial hyperlipemia, gut dysbiosis, genetic mutations. Cardiovascular diseases leading cause death in patients MASLD. These have incidence coronary artery disease, carotid structural functional cardiac abnormalities, valvulopathies, as well arrhythmias conduction disorders. In review, we present latest data on association between MASLD focusing that explain correlation these two pathologies. Given high rates morbidity mortality among MASLD, consider it imperative to raise awareness risks associated condition within general population. Further research essential clarify linked This understanding may facilitate identification new diagnostic prognostic biomarkers for patients, novel therapeutic targets.

Язык: Английский

---

Association of high-sensitivity C-reactive protein with hepatic fibrosis in patients with metabolic dysfunction-associated steatotic liver disease

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 10, 2025

Objective This study aimed to investigate the association between high-sensitivity C-reactive protein (hsCRP) levels and hepatic fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) assess its predictive efficacy. Methods The included 1,477 participants from United States 1,531 China diagnosed MASLD. Liver stiffness measurement (LSM) controlled attenuation parameter (CAP) were assessed by vibration-controlled transient elastography (VCTE) evaluate presence degree of steatosis. relationship hsCRP MASLD was examined using multivariable-adjusted restricted cubic spline (RCS) models. Additionally, subgroup analyses conducted potential heterogeneity among different characteristic subgroups. Results results demonstrated a significant correlation elevated an increased risk fibrosis, advanced cirrhosis US cohort (OR 2.22, 1.69, 2.85, respectively; all P &lt;0.05). Chinese consistent those cohort, there positive 2.53, 3.85, 3.78, respectively, &lt;0.001). RCS analysis revealed non-linear disparate inflection point values observed across cohorts (approximately 9 mg/L 4 cohort). impact on varied subgroups distinct characteristics. Conclusion present MASLD, notable dose-response relationships differences.

Язык: Английский

---

Glucosamine supplementation attenuates progression of metabolic dysfunction-associated steatotic liver disease and related comorbidities

Clinical Nutrition, Год журнала: 2025, Номер 47, С. 119 - 128

Опубликована: Фев. 14, 2025

Язык: Английский

---

Adherence to the planetary health diet index and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 20, 2025

Adherence to the Planetary Health Diet Index (PHDI) has been shown benefit both individual health and planet. However, its impact on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unclear. This study aimed investigate relationship between PHDI adherence MASLD risk. We analyzed a cohort of 15,865 adults (aged ≥18 years) using data from National Nutrition Examination Survey (NHANES, 2005-2018). The was derived 24-h dietary assessments comprised scores 15 food groups. Multivariate logistic regression used association MASLD, while restricted cubic spline (RCS) threshold analysis were employed explore potential non-linear relationship. Subgroup analyses conducted assess influence various demographic clinical characteristics observed associations. Mediation performed evaluate indirect effect weighted quantile sum (WQS) nutrients MASLD. Among cohort, 6,125 individuals diagnosed with revealed that higher quintile significantly associated reduced risk in fully adjusted model (OR = 0.610, 95%CI 0.508-0.733, p < 0.001). Notably, nonlinear relationships through RCS (p 0.002). indicated particularly effective reducing among females, those education attainment, living partner. WQS identified saturated fatty acids as most significant factor contributing (weight 0.313). Additionally, BMI waist circumference (81.47 87.66%, respectively) partially mediated risk, suggesting operates, part, circumference. remained robust across multiple sensitivity analyses. Our findings indicate is linked lower providing crucial insights for strategies at mitigating epidemic simultaneously fostering environmental sustainability.

Язык: Английский

---