Pharmaceuticals,
Год журнала:
2023,
Номер
16(11), С. 1515 - 1515
Опубликована: Окт. 24, 2023
Ovarian
cancer
(OC)
is
one
of
the
most
lethal
gynecological
malignancies.
The
use
biological
compounds
such
as
non-coding
RNAs
(ncRNAs)
being
considered
a
therapeutic
option
to
improve
or
complement
current
treatments
since
deregulation
ncRNAs
has
been
implicated
in
pathogenesis
and
progression
OC.
Old
drugs
with
antitumoral
properties
have
also
studied
context
cancer,
although
their
antitumor
mechanisms
are
not
fully
clear.
For
instance,
antidiabetic
drug
metformin
shown
pleiotropic
effects
several
vitro
models
including
Interestingly,
reported
regulate
ncRNAs,
which
could
explain
its
diverse
on
tumor
cells.
In
this
review,
we
discuss
mechanism
epigenetic
regulation
described
for
metformin,
focus
evidence
metformin-dependent
microRNA
(miRNAs)
long
RNA
(lncRNAs)
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 25
Опубликована: Июль 11, 2022
Biological
aging
or
senescence
is
a
course
in
which
cellular
function
decreases
over
period
of
time
and
consequence
altered
signaling
mechanisms
that
are
triggered
stressed
cells
leading
to
cell
damage.
Aging
among
the
principal
risk
factors
for
many
chronic
illnesses
such
as
cancer,
cardiovascular
disorders,
neurodegenerative
diseases.
Taking
this
into
account,
targeting
fundamental
therapeutically
may
effectively
impact
numerous
illnesses.
Selecting
ideal
therapeutic
options
order
hinder
process
decelerate
progression
age-related
diseases
valuable.
Along
options,
life
style
modifications
well
render
aging.
The
affected
by
alteration
pathways
amid
mTOR,
SIRT1,
AMPK
most
emphasized.
Herein,
we
have
discussed
focusing
mainly
on
mentioned
role
inflammation
autophagy
Moreover,
drugs
natural
products
with
antiaging
properties
detail.
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e34859 - e34859
Опубликована: Июль 18, 2024
Gastric
cancer
(GC)
is
a
malignant
tumor
with
high
global
mortality
rate
that
currently
difficult
to
treat.
Dextran
sulfate
(DS),
safe
anti-tumor
agent,
can
effectively
inhibit
the
biological
behavior
of
gastric
cancer;
however,
its
mechanism
action
not
fully
understood.
Therefore,
this
study
aimed
at
elucidate
potential
mechanisms
action.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Авг. 29, 2024
Despite
reaching
enormous
achievements
in
therapeutic
approaches
worldwide,
GBM
still
remains
the
most
incurable
malignancy
among
various
cancers.
It
emphasizes
necessity
of
adjuvant
therapies
from
perspectives
both
patients
and
healthcare
providers.
Therefore,
emerging
studies
have
focused
on
complementary
therapies.
Among
them,
metabolic
therapy
has
received
special
attention,
metformin
been
considered
as
a
treatment
types
cancer,
including
GBM.
is
clearly
evident
that
efficient
without
comprehensive
evaluation
key
mechanisms
not
possible.
studied
mechanisms,
one
more
challenging
ones
effect
apoptosis
senescence.
Moreover,
well
known
an
insulin
sensitizer.
However,
if
signaling
facilitated
tumor
microenvironment,
it
may
result
growth.
to
partially
resolve
some
paradoxical
issues,
we
conducted
narrative
review
related
address
following
questions
comprehensively
possible:
1)
Does
improvement
cellular
function
resulting
detrimental
or
beneficial
effects
cells?
2)
If
these
are
cells,
which
important:
senescence?
3)
What
determines
decision
between
Cells,
Год журнала:
2023,
Номер
12(17), С. 2182 - 2182
Опубликована: Авг. 30, 2023
The
biguanide
drug
metformin
is
widely
used
in
type
2
diabetes
mellitus
therapy,
due
to
its
ability
decrease
serum
glucose
levels,
mainly
by
reducing
hepatic
gluconeogenesis
and
glycogenolysis.
A
considerable
number
of
studies
have
shown
that
metformin,
besides
antidiabetic
action,
can
improve
other
disease
states,
such
as
polycystic
ovary
disease,
acute
kidney
injury,
neurological
disorders,
cognitive
impairment
renal
damage.
In
addition,
well
known
suppress
the
growth
progression
different
types
cancer
cells
both
vitro
vivo.
Accordingly,
several
epidemiological
suggest
capable
lowering
risk
rate
deaths
among
diabetic
patients.
antitumoral
effects
been
proposed
be
mediated
activation
AMP-activated
protein
kinase
(AMPK).
However,
a
signaling
pathways,
dependent
independent
AMPK
activation,
reported
involved
action.
Among
these,
Wingless
Int
pathway
recently
included.
Here,
we
will
focus
our
attention
on
main
molecular
mechanisms
involved.
eNeuro,
Год журнала:
2021,
Номер
9(1), С. ENEURO.0421 - 21.2021
Опубликована: Дек. 13, 2021
Abstract
Mild
traumatic
brain
injury
(mTBI)
can
initiate
complex
pathophysiological
changes
in
the
brain.
Numerous
cellular
and
molecular
mechanisms
underlying
these
pathologic
are
altered
after
injury,
including
those
involved
energy
utilization,
excitotoxicity,
ionic
disturbances,
inflammation.
It
is
thought
that
targeting
multiple
may
be
necessary
to
produce
meaningful
reductions
pathology
improve
outcome.
Previous
studies
have
reported
anti-diabetic
drug
metformin
also
affect
inflammatory,
cell
survival,
metabolic
outcomes,
possibly
by
acting
on
targets
and/or
pathways.
We
therefore
questioned
whether
treatment
reduce
repeat
mild
closed
head
(rmCHI)
male
C57Bl/6
mice.
found
metformin,
administered
acutely
each
impact,
resulted
markedly
reduced
white
matter
damage,
astrogliosis,
loss
of
hippocampal
parvalbumin
neurons,
improved
mitochondrial
function.
In
addition,
both
motor
cognitive
functions
were
significantly
when
tested
discontinuation
treatment.
These
suggest
beneficial
as
a
for
concussion.
Archives of Medical Science,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 20, 2023
Introduction
Metformin
(Met),
a
first-line
oral
anti-type
2
diabetes
medication
used
globally,
has
been
shown
to
hinder
cancer
progression
via
regulation
of
microRNAs
(miRNAs).
The
previous
reports
on
the
relationship
between
Met
use
and
risk
esophageal
squamous
cell
carcinoma
(ESCC)
have
controversial.
Hence,
this
study
aimed
explore
how
affected
ESCC
underlying
molecular
mechanism.
Material
methods
Cell
migration,
viability
invasiveness
were
respectively
investigated
using
wound
healing,
CCK-8
transwell
assay.
expressions
miR-141-3p
Sciellin
(SCEL)
mRNA
examined
by
mean
quantitative
real-time
PCR
(qRT-PCR)
assay,
SCEL
protein
level
was
quantified
western
blotting.
In
vivo
tests
performed
animals.
predicted
binding
more
evidenced
dual-luciferase
Results
treatment
in
largely
impaired
viability,
migration
invasiveness.
MiR-141-3p
showed
high
expression
downregulated
cells
after
treatment.
upregulation
Met-administered
restored
proliferative
ability,
also
attenuated
anti-tumor
effect
vivo.
targeted
whose
declined
ESCC,
reinforced
depleted
thus
partially
abolished
anti-cancer
impacts
Met-treated
cells.
Conclusions
restrains
regulating
miR-141-3p/SCEL
axis.
Our
findings
clearly
show
that
is
associated
with
lower
its
anticancer
could
potentially
be
treat
ESCC.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(11), С. 1515 - 1515
Опубликована: Окт. 24, 2023
Ovarian
cancer
(OC)
is
one
of
the
most
lethal
gynecological
malignancies.
The
use
biological
compounds
such
as
non-coding
RNAs
(ncRNAs)
being
considered
a
therapeutic
option
to
improve
or
complement
current
treatments
since
deregulation
ncRNAs
has
been
implicated
in
pathogenesis
and
progression
OC.
Old
drugs
with
antitumoral
properties
have
also
studied
context
cancer,
although
their
antitumor
mechanisms
are
not
fully
clear.
For
instance,
antidiabetic
drug
metformin
shown
pleiotropic
effects
several
vitro
models
including
Interestingly,
reported
regulate
ncRNAs,
which
could
explain
its
diverse
on
tumor
cells.
In
this
review,
we
discuss
mechanism
epigenetic
regulation
described
for
metformin,
focus
evidence
metformin-dependent
microRNA
(miRNAs)
long
RNA
(lncRNAs)
