HPV-driven cancer: from epidemiology to the HPV-driven tumor board proposal, everything you wanted to know but were afraid to ask
Clinical & Translational Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Язык: Английский
Cervical Cancer Genetic Profile through Circulating Tumor DNA: What Can We Learn from Blood?
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 825 - 825
Опубликована: Июль 10, 2024
Cervical
cancer
(CC)
is
one
of
the
deadliest
gynecological
cancers
worldwide.
Human
papillomavirus
main
etiological
agent
responsible
for
initiation
and
development
most
CC
cases.
The
standard
method
utilized
screening
in
global
population
cytological
Pap
smear
test.
Despite
its
effective
validity
detecting
precancerous
lesions
response
to
layer
stages
this
disease,
greater
diagnostic
reliability
are
needed,
as
well
an
improvement
specificity
sensitivity.
In
context,
use
liquid
biopsies,
like
blood,
isolation
circulating
tumor
DNA
(ctDNA)
screening,
diagnosis,
prognosis,
surveillance
could
fill
gaps
that
still
exist.
present
review,
we
aim
study
literature
order
collect
knowledge
on
blood-based
biopsy
based
descriptions
precious
molecular
content
utilization
a
potential
tool
patients’
management.
We
will
mainly
focus
important
role
novel
ctDNA
unique
possibilities
additionally
HPV-ctDNA
at
various
clinical
application.
Язык: Английский
The Role of Circulating Tumor DNA in Ovarian Cancer
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3117 - 3117
Опубликована: Сен. 10, 2024
Ovarian
cancer
is
the
deadliest
of
all
gynecological
diseases
because
its
diagnosis
and
treatment
still
pose
many
problems.
Surgical
excision,
hormone
therapy,
radiation,
chemotherapy,
or
targeted
therapy
for
eradicating
main
tumor
halting
spread
metastases
are
among
options
available
to
individuals
with
ovarian
cancer,
depending
on
disease’s
stage.
Tumor
DNA
that
circulates
in
a
patient’s
bodily
fluids
has
been
studied
recently
as
possible
novel
biomarker
number
cancers,
well
means
quantifying
size
evaluating
efficacy
therapy.
The
most
significant
alterations
we
could
find
ctDNA
patients—such
chromosomal
instability,
somatic
mutations,
methylation—are
discussed
this
review.
Additionally,
talk
about
utility
diagnosis,
prognosis,
response
prediction
these
patients.
Язык: Английский
MicroRNA-Based Liquid Biopsy for Cervical Cancer Diagnostics and Treatment Monitoring
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13271 - 13271
Опубликована: Дек. 10, 2024
Despite
prevention
strategies,
cervical
cancer
remains
a
significant
public
health
issue.
Human
papillomavirus
plays
critical
role
in
its
development,
and
early
detection
is
vital
to
improve
patient
outcomes.
The
incidence
of
projected
rise,
necessitating
better
diagnostic
tools.
Traditional
screening
methods
like
the
cytological
examination
human
testing
have
limitations
sensitivity
reproducibility.
Liquid-based
cytology
offers
some
improvements,
but
need
for
more
reliable
sensitive
techniques
persists,
particularly
detecting
precancerous
lesions.
Liquid
biopsy
non-invasive
method
that
analyzes
cancer-derived
products
biofluids
blood,
offering
potential
real-time
monitoring
tumor
progression,
metastasis,
treatment
response.
It
can
be
based
on
circulating
cells
(CTCs),
free
DNA
(cfDNA),
microRNAs
(miRNAs).
This
review
underlines
microRNAs,
which
are
transported
by
extracellular
vesicles.
Overall,
this
article
underscores
importance
continued
research
into
liquid
enhance
monitoring.
Язык: Английский