Proteomes,
Год журнала:
2024,
Номер
12(3), С. 26 - 26
Опубликована: Сен. 13, 2024
Despite
the
advances
in
modern
cancer
therapy,
malignant
diseases
are
still
a
leading
cause
of
morbidity
and
mortality
worldwide.
Conventional
treatment
methods
frequently
lead
to
side
effects
drug
resistance
patients,
highlighting
need
for
novel
therapeutic
approaches.
Recent
findings
have
identified
existence
non-canonical
micropeptides,
an
additional
layer
proteome
complexity,
also
called
microproteome.
These
small
peptides
promising
class
agents
with
potential
address
limitations
current
treatments.
The
microproteome
is
encoded
by
regions
genome
historically
annotated
as
non-coding,
its
has
been
revealed
thanks
recent
proteomic
bioinformatic
technology,
which
dramatically
improved
understanding
complexity.
Micropeptides
shown
be
biologically
active
several
types,
indicating
their
role.
Furthermore,
they
characterized
low
toxicity
high
target
specificity,
demonstrating
development
better
tolerated
drugs.
In
this
review,
we
survey
landscape
known
micropeptides
role
progression
or
treatment,
discuss
anticancer
agents,
describe
methodological
challenges
facing
field
research.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 10, 2025
Non-coding
RNAs
(ncRNAs)
have
a
significant
role
in
gene
regulation,
especially
cancer
and
inflammatory
diseases.
ncRNAs,
such
as
microRNA,
long
non-coding
RNAs,
circular
alter
the
transcriptional,
post-transcriptional,
epigenetic
expression
levels.
These
molecules
act
biomarkers
possible
therapeutic
targets
because
aberrant
ncRNA
has
been
directly
connected
to
tumor
progression,
metastasis,
response
therapy
research.
ncRNAs’
interactions
with
multiple
cellular
pathways,
including
MAPK,
Wnt,
PI3K/AKT/mTOR,
impact
processes
like
proliferation,
apoptosis,
immune
responses.
The
potential
of
RNA-based
therapeutics,
anti-microRNA
microRNA
mimics,
restore
normal
is
being
actively
studied.
Additionally,
tissue-specific
patterns
ncRNAs
offer
unique
opportunities
for
targeted
therapy.
Specificity,
stability,
responses
are
obstacles
use
ncRNAs;
however,
novel
strategies,
modified
oligonucleotides
delivery
systems,
developed.
profiling
may
result
more
individualized
successful
treatments
precision
medicine
advances,
improving
patient
outcomes
creating
early
diagnosis
monitoring
opportunities.
current
review
aims
investigate
roles
diseases,
focusing
on
their
mechanisms
regulation
implications
non-invasive
diagnostics
therapies.
A
comprehensive
literature
was
conducted
using
PubMed
Google
Scholar,
research
published
between
2014
2025.
Studies
were
selected
based
rigorous
inclusion
criteria,
peer-reviewed
status
relevance
Non-English,
non-peer-reviewed,
inconclusive
studies
excluded.
This
approach
ensures
that
findings
presented
high-quality
relevant
sources.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Фев. 19, 2025
In
the
present
era,
noncoding
RNAs
(ncRNAs)
have
become
a
subject
of
considerable
scientific
interest,
with
peptides
encoded
by
ncRNAs
representing
particularly
promising
avenue
investigation.
The
identification
ncRNA-encoded
in
human
cancers
is
increasing.
These
regulate
cancer
progression
through
multiple
molecular
mechanisms.
Here,
we
delineate
patterns
diverse
and
provide
synopsis
methodologies
employed
for
that
possess
capacity
to
encode
these
peptides.
Furthermore,
discuss
impacts
on
biological
behavior
cells
underlying
conclusion,
describe
prospects
challenges
need
be
overcome.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 8, 2025
Micropeptides,
these
small
proteins
derived
from
non-coding
RNA,
typically
consist
of
no
more
than
100
amino
acids
in
length.
Despite
the
challenges
analysis
and
identification,
their
various
critical
functions
within
organisms
cannot
be
overlooked.
They
play
a
significant
role
maintaining
energy
metabolism
balance,
regulating
immune
system,
influencing
development
tumors,
which
also
gives
them
decisive
impact
on
occurrence
diseases.
This
review
aims
to
outline
potential
value
micropeptides,
introducing
tissue
classification
distribution,
biological
functions,
mechanisms,
with
focus
as
diagnostic
markers
therapeutic
drugs.
International Journal of Cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Abstract
Micropeptides
are
commonly
identified
as
peptides
encoded
by
non‐coding
RNAs
(ncRNAs).
In
the
short
open
reading
frame
(sORF)
of
ncRNAs,
there
is
a
base
sequence
encoding
functional
micropeptides,
which
great
significance
in
biological
field.
Recently,
micropeptides
regulate
diverse
processes,
including
mitochondrial
metabolism,
calcium
transport,
mRNA
splicing,
signal
transduction,
myocyte
fusion,
and
cellular
senescence,
regulating
homeostasis
internal
environment
cancer's
incidence
progression.
Especially,
study
cancer
about
potential
regulatory
mechanism
will
be
conducive
to
further
understanding
process
initiation
development.
More
more
research
shows
have
been
confirmed
play
an
essential
role
emergence
multiple
kinds
cancers,
Breast
cancer,
Colon
Colorectal
Glioma,
Glioblastoma,
Liver
cancer.
This
review
presents
comprehensive
synthesis
latest
advancements
our
roles
cells,
with
particular
focus
on
networks
involving
oncogenesis.
The
new
mode
action
provides
innovative
ideas
for
diagnosis
treatment.
Moreover,
we
explored
significant
capacity
diagnostic
biomarkers
targets
anti‐cancer
therapies
clinical
settings,
highlighting
their
development
micropeptide‐based
tools
therapeutics.
Expert Opinion on Therapeutic Targets,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Squalene
epoxidase
(SQLE)
is
a
pivotal
enzyme
in
sterol
biosynthesis,
catalyzing
the
conversion
of
squalene
to
2,3-oxidosqualene.
Beyond
its
core
role
cholesterol
homeostasis,
SQLE
implicated
cancer,
hypercholesterolemia,
and
fungal
infections,
positioning
it
as
valuable
therapeutic
target.
We
conducted
comprehensive
literature
search
across
primary
databases
gather
vitro,
silico,
vivo
evidence
on
SQLE.
This
review
explores
enzyme's
structural
functional
features,
including
substrate
specificity
catalytic
mechanisms,
examines
inhibitor
interactions.
Computational
methods
predict
-
dynamics,
guiding
drug
design,
while
investigations
clarify
SQLE's
metabolic
disorders
tumorigenesis.
Challenges
include
resistance
study
discrepancies,
but
emerging
technologies,
such
cryo-electron
microscopy
CRISPR
editing,
offer
new
avenues
for
deeper
exploration.
an
underexplored
yet
promising
target,
with
particular
relevance
oxidative
stress,
ferroptosis,
gut
microbiota
research.
Overcoming
current
barriers
through
advanced
technologies
multidisciplinary
strategies
could
propel
SQLE-targeted
treatments
into
clinical
practice,
supporting
precision
medicine
broader
translational
applications.
Cancer
develops
from
abnormal
cell
growth
in
the
body,
causing
significant
mortalities
every
year.
To
date,
potent
therapeutic
approaches
have
been
developed
to
eradicate
tumor
cells,
but
intolerable
toxicity
and
drug
resistance
can
occur
treated
patients,
limiting
efficiency
of
existing
treatment
strategies.
Therefore,
searching
for
novel
genes
critical
cancer
progression
response
is
urgently
needed
successful
therapy.
Recent
advances
bioinformatic
proteomic
techniques
allowed
identification
a
category
peptides
encoded
by
non-canonical
open
reading
frames
(ncORFs)
historically
non-coding
genomic
regions.
Surprisingly,
many
ncORFs
express
functional
microproteins
that
play
vital
role
human
cancers.
In
this
review,
we
provide
comprehensive
description
different
ncORF
types
with
coding
capacity
technological
methods
discovering
among
genomes.
We
also
summarize
diagnostic
prognostic
value
these
as
well
their
carcinogenic
underestimated
potential
targets.
Cancers,
Год журнала:
2024,
Номер
16(15), С. 2660 - 2660
Опубликована: Июль 26, 2024
Cancer
develops
from
abnormal
cell
growth
in
the
body,
causing
significant
mortalities
every
year.
To
date,
potent
therapeutic
approaches
have
been
developed
to
eradicate
tumor
cells,
but
intolerable
toxicity
and
drug
resistance
can
occur
treated
patients,
limiting
efficiency
of
existing
treatment
strategies.
Therefore,
searching
for
novel
genes
critical
cancer
progression
response
is
urgently
needed
successful
therapy.
Recent
advances
bioinformatics
proteomic
techniques
allowed
identification
a
category
peptides
encoded
by
non-canonical
open
reading
frames
(ncORFs)
historically
non-coding
genomic
regions.
Surprisingly,
many
ncORFs
express
functional
microproteins
that
play
vital
role
human
cancers.
In
this
review,
we
provide
comprehensive
description
different
ncORF
types
with
coding
capacity
technological
methods
discovering
among
genomes.
We
also
summarize
carcinogenic
such
as
pTINCR
HOXB-AS3
regulating
hallmarks
cancer,
well
roles
CIP2A-BP
diagnosis
prognosis.
discuss
how
AKT-174aa
DDUP
are
involved
anti-cancer
underestimated
potential
targets.
