Advancements in Colorectal Cancer Immunotherapy: From CAR-T Cells to Exosome-Based Therapies
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Янв. 4, 2025
Colorectal
cancer
(CRC)
continues
to
be
a
major
worldwide
health
issue,
with
elevated
death
rates
linked
late
stages
of
the
illness.
Immunotherapy
has
made
significant
progress
in
developing
effective
techniques
improve
immune
system's
capacity
identify
and
eradicate
cancerous
cells.
This
study
examines
most
recent
advancements
CAR-T
cell
treatment
exosome-based
immunotherapy
for
CRC.
therapy,
although
treating
blood
cancers,
encounters
obstacles
when
used
against
solid
tumors
such
as
These
include
presence
an
immunosuppressive
tumor
microenvironment
scarcity
tumor-specific
antigens.
Nevertheless,
novel
strategies
like
dual-receptor
cells
combination
therapy
involving
cytokines
have
demonstrated
promise
surmounting
these
obstacles.
Exosome-based
is
promising
approach
targeted
delivery
therapeutic
drugs
cells,
high
specificity
minimal
off-target
effects.
However,
there
are
still
overcome
field,
resistance
treatment,
adverse
effects
associated
system,
necessity
more
individualized
methods.
The
current
research
focused
on
enhancing
therapies,
results
patients,
ultimately
incorporating
innovative
immunotherapeutic
approaches
into
standard
protocols
Язык: Английский
Cell-based Immunotherapy in Esophageal Cancer
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Март 10, 2025
Esophageal
cancer
(EC)
is
among
the
most
common
illnesses
globally,
and
its
prognosis
unfavorable.
Surgery,
radiotherapy,
chemotherapy
are
primary
therapy
options
for
EC.
Despite
occasional
efficacy
of
these
traditional
treatment
modalities,
individuals
with
EC
remain
at
a
significant
risk
local
recurrence
metastasis.
Consequently,
innovative
efficacious
medicines
required.
In
recent
decades,
clinical
practice
has
effectively
implemented
cell
therapy,
which
includes
both
stem
non-stem
cell-based
approaches,
as
an
tumor
treatment,
offering
renewed
hope
to
patients
esophageal
squamous
carcinoma
(ESCC).
This
paper
examines
theoretical
framework
contemporary
advancements
in
We
further
described
current
studies
summarized
essential
data
related
survival
safety
assessments.
Язык: Английский
Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer
Medical Oncology,
Год журнала:
2025,
Номер
42(4)
Опубликована: Март 18, 2025
Язык: Английский
Functional tumor-derived exosomes in NSCLC progression and clinical implications
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
Non-small
cell
lung
cancer
(NSCLC)
accounts
for
approximately
85%
of
all
cases
and
remains
one
the
leading
causes
cancer-related
mortality
worldwide.
The
high
rate
is
primarily
driven
by
delayed
diagnosis,
rapid
metastasis,
frequent
recurrence.
Tumor-derived
exosomes
(TEXs)
have
emerged
as
critical
mediators
in
NSCLC
progression,
offering
valuable
insights
into
tumor
microenvironment.
Exosomes
are
small
membrane
vesicles
that
facilitate
intercellular
communication
transport
bioactive
molecules,
including
proteins,
RNAs,
DNAs,
thereby
reflecting
genetic
complexity
tumors.
These
play
a
key
role
promoting
epithelial-mesenchymal
transition
(EMT),
neovascularization,
drug
resistance,
immune
evasion,
which
pivotal
development
NSCLC.
This
review
explores
diverse
roles
TEXs
focusing
on
their
involvement
pre-metastatic
niche
formation,
tissue
modulation.
Specifically,
we
discuss
exosome-associated
RNAs
proteins
NSCLC,
contribute
to
growth
metastasis.
Furthermore,
explore
potential
biomarkers
emphasizing
application
prognosis,
prediction
resistance
targeted
therapies
immunotherapies.
Язык: Английский
Novel therapeutic approaches for non-small cell lung cancer: an updated view
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 29
Опубликована: Апрель 5, 2025
Non-small
cell
lung
cancer
(NSCLC)
continues
to
be
one
of
the
leading
causes
cancer-related
mortality
globally.
Most
patients
who
undergo
surgical
procedures
may
encounter
distant
metastasis
or
local
recurrence,
necessitating
supplementary
treatments
such
as
radiation
therapy,
chemotherapy,
targeted
therapy
adjuvant
alternatives.
Recent
advancements
in
molecular
biology
and
immunotherapy
have
paved
way
for
innovative
therapeutic
approaches
that
target
specific
genetic
mutations
promote
immune
response
against
tumor
cells.
This
review
explores
emerging
therapies,
including
therapies
tyrosine
kinase
inhibitors
(TKIs)
actionable
(e.g.,
EGFR,
ALK,
ROS1),
well
role
checkpoint
(ICIs)
employ
body's
system
combat
cancer.
Additionally,
we
discuss
potential
exosome
promising
nanotherapeutic
options
treatment
NSCLC.
study
attempts
provide
a
thorough
overview
changing
landscape
NSCLC
its
implications
enhancing
patient
outcomes
by
presenting
these
techniques.
Язык: Английский
Smart nanoparticle delivery of cancer vaccines enhances tumor immune responses: a review
Frontiers in Nanotechnology,
Год журнала:
2025,
Номер
7
Опубликована: Апрель 14, 2025
Cancer
arises
from
the
uncontrolled
proliferation
of
tumor
cells
within
body.
As
incidence
cancer
continues
to
rise,
its
treatment
has
become
a
critical
focus
for
clinicians.
The
body
possesses
immune
surveillance
mechanism
designed
inhibit
cells.
When
tumor-associated
mutant
antigens
appear
on
cell
surface,
antigen-presenting
cells,
as
dendritic
present
these
specific
such
T
lymphocytes,
thereby
promoting
an
response
and
enhancing
cytotoxic
effect
Concurrently,
system
develops
memory,
akin
elicited
by
vaccination.
While
traditional
diseases
like
tuberculosis
tetanus
can
be
prevented
treated
through
vaccination,
development
vaccines
remains
in
nascent
stages.
Tumor-specific
originate
patient’s
own
or
generated
mutation.
Thus,
presentation
tumor-specific
is
pivotal
anti-tumor
immunotherapy.
Advances
nanoscience
offer
novel
approaches
Nanoparticles
(NPs)
engineered
nanotechnology
have
garnered
significant
attention
due
their
diverse,
favorable,
stable
properties.
These
NPs
effectively
encapsulate
chemotherapy
drugs
proteins,
facilitating
targeted
delivery
vivo
.
Common
carriers
include
liposomes,
polymeric
nanoparticles,
metal
among
others.
intelligent
systems
enhance
efficient
antigen
presentation,
augmenting
responses.
sourced
In
this
review,
we
summarize
current
methodologies
obtaining
various
discuss
how
delivered
via
different
bolster
immunity.
Additionally,
clinical
translation
perspective,
explore
challenges
opportunities
associated
with
responses
smart
NP
vaccines.
We
aim
review
inspire
new
strategies
use
advance
research
Язык: Английский
Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment
Molecular Biology Reports,
Год журнала:
2024,
Номер
52(1)
Опубликована: Дек. 26, 2024
Язык: Английский
Extracellular Vesicles and Their Applications in Tumor Diagnostics and Immunotherapy
Cells,
Год журнала:
2024,
Номер
13(23), С. 2031 - 2031
Опубликована: Дек. 9, 2024
Extracellular
vesicles
(EVs)
are
cell-derived
nanoparticles
that
have
attracted
significant
attention
in
the
investigation
of
human
health
and
disease,
including
cancer
biology
its
clinical
management.
Concerning
cancer,
EVs
been
shown
to
influence
numerous
aspects
oncogenesis,
tumor
proliferation
metastasis.
can
augment
immune
system
implicated
virtually
all
innate
adaptive
immunity.
With
immunotherapy
changing
landscape
treatment
across
multiple
disease
sites,
it
is
paramount
understand
their
mechanisms
action
further
improve
upon
efficacy.
Despite
a
rapidly
growing
body
evidence
supporting
utility
diagnostics
therapeutics,
application
trials
involving
solid
tumors
remains
limited.
To
date,
relatively
few
known
incorporate
this
context,
mainly
employing
them
as
biomarkers.
help
address
gap,
review
summarizes
applications
provides
brief
overview
roles
play
biology,
immunology,
proposed
implications
immunotherapy.
The
impetus
leverage
future
correlative
studies
crucial,
they
ideally
positioned
synergize
with
advancements
multi-omics
research
therapeutic
discovery
our
understanding
biology.
Язык: Английский