Octadecyl Gallate and Lipid‐Modified MnSe₂ Nanoparticles Enhance Radiosensitivity in Esophageal Squamous Cell Carcinoma and Promote Radioprotection in Normal Tissues

Advanced Materials, Год журнала: 2024, Номер 36(23)

Опубликована: Фев. 26, 2024

Abstract Radiotherapy, a widely used therapeutic strategy for esophageal squamous cell carcinoma (ESCC), is always limited by radioresistance of tumor tissues and side‐effects on normal tissues. Herein, signature based four core genes cyclic GMP‐AMP synthase‐stimulator interferon (cGAS‐STING) pathway, developed to predict prognosis assess immune infiltration, indicating that the cGAS‐STING pathway radiotherapy efficacy are closely intertwined in ESCC. A novel lipid‐modified manganese diselenide nanoparticle (MnSe 2 ‐lipid) with extraordinarily uniform sphere morphology microenvironment (TME) responsiveness simultaneously overcome reduce radiation. The MnSe encapsulated lipid effectively achieves accumulation. Octadecyl gallate surface forming pH‐responsive metal–phenolic covalent realizes rapid degradation TME. released Mn 2+ promotes radiosensitivity generating reactive oxygen species induced Fenton‐like reaction activating pathway. Spontaneously, selenium strengthens response promoting secretion cytokines increasing white blood cells, performs antioxidant activity radiotherapy. Overall, this multifunctional remedy which responsive TME capable providing pathway‐mediated immunostimulation chemodynamic therapy, radioprotection tissues, highlighted here optimize ESCC treatment.

Язык: Английский

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A Self‐Catalytic NO/O₂ Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted "prosthetic-Arginine" coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O

Язык: Английский

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The Cancer Antioxidant Regulation System in Therapeutic Resistance

Antioxidants, Год журнала: 2024, Номер 13(7), С. 778 - 778

Опубликована: Июнь 27, 2024

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cells adeptly maintain elevated levels both ROS and antioxidants through process termed "redox reprogramming". This balance optimizes proliferative influence while simultaneously reducing potential for cause damage cell. some cases, adapted antioxidant machinery can hamper efficacy treatments neoplastic diseases, representing significant facet resistance mechanisms observed therapy. this review, we outline contribution systems therapeutic resistance. We detail fundamental constituents these systems, encompassing central regulatory involving transcription factors (of particular importance is KEAP1/NRF2 signaling axis), molecular effectors antioxidants, auxiliary responsible NADPH generation. Furthermore, present recent clinical trials based on targeted treatment cancer, assessing as well challenges strategy Additionally, summarize pressing issues field, with aim illuminating path toward emergence novel anticancer approaches by orchestrating redox signaling.

Язык: Английский

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Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Фев. 23, 2024

Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, lipids can serve as messengers for intercellular communication. They play critical roles in the exchange information between tumor cells microenvironment (TME). The TME consists mesenchymal components extracellular matrix (ECM), fibroblasts being most abundant cell type mesenchyme. Cancer-associated (CAFs) derived from normal stem that activated TME. CAFs secrete exosomes to modulate proliferation, invasion, migration, drug resistance, other biological processes tumors. Additionally, manipulate function behavior through direct cell-cell interactions. This review provides summary crosstalk GI exosomes, along potential underlying mechanisms.

Язык: Английский

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Inflammation in cancer: therapeutic opportunities from new insights

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 24, 2025

As one part of the innate immune response to external stimuli, chronic inflammation increases risk various cancers, and tumor-promoting is considered enabling characteristics cancer development. Recently, there has been growing evidence on role anti-inflammation therapy in prevention treatment. And researchers have already achieved several noteworthy outcomes. In review, we explored underlying mechanisms by which affects occurrence development cancer. The pro- or anti-tumor effects these inflammatory factors such as interleukin, interferon, chemokine, inflammasome, extracellular matrix are discussed. Since FDA-approved drugs like aspirin show obvious effects, unique advantages due their relatively fewer side with long-term use compared chemotherapy drugs. make them promising candidates for chemoprevention. Overall, this review discusses molecules carcinogenesis new molecules-directed therapeutic opportunities, ranging from cytokine inhibitors/agonists, inflammasome inhibitors, some inhibitors that expected be applied clinical practice, well recent discoveries effect non-steroidal anti-inflammatory steroidal disadvantages application chemoprevention also

Язык: Английский

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Enhancing X‐Ray Sensitization with Multifunctional Nanoparticles

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Апрель 26, 2024

Abstract In the progression of X‐ray‐based radiotherapy for treatment cancer, incorporation nanoparticles (NPs) has a transformative impact. This study investigates potential NPs, particularly those comprised high atomic number elements, as radiosensitizers. aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications NPs in encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along contributions photodynamic/photothermal therapy, imaging enhancement, integration artificial intelligence technology. Despite promising preclinical outcomes, paper acknowledges challenges clinical translation these findings. conclusion maintains an optimistic stance, emphasizing ongoing trials technological advancements that bolster personalized approaches. advocates continuous research validation, envisioning revolutionary paradigm cancer ultimately enhancing patient outcomes.

Язык: Английский

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Unraveling the complexities of colorectal cancer and its promising therapies – An updated review

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113325 - 113325

Опубликована: Окт. 14, 2024

Язык: Английский

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Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Янв. 16, 2024

Background While simultaneous chemoradiotherapy remains the established therapeutic modality for patients afflicted with locally advanced esophageal cancer, effectiveness of this radical approach falls short desired outcome. Numerous investigations have illuminated prospect enhancing efficacy through amalgamation and immunotherapeutic interventions. Consequently, we embarked on an examination to scrutinize potential survival advantages conferred by confluence immunotherapy in relation unresectable carcinoma, drawing upon extensive SEER database our analysis. Methods We extracted clinicopathological attributes statistics diagnosed within temporal span encompassing years 2004-2014 2019-2020, from database. To discern disparities both overall (OS) cancer-specific (CSS) between cohorts subjected combined alone, employed analytical tools such as Kaplan-Meier analysis, Log-rank test, Cox regression proportional risk model, propensity-matched score (PSM) methodology. Results A total 7,758 eligible were encompassed research, 6,395 individuals having undergone while 1,363 received treatment immunotherapy. After 1:4 propensity matching, 6,447 successfully harmonized, yielding a well-balanced cohort. The curves demonstrated substantial enhancement OS (P = 0.0091) CSS < 0.001) group compared alone. Further multivariable analysis PSM confirmed that benefits OS(HR=0.89, 95% CI 0.81-0.98) (HR=0.68, 0.61-0.76). In addition, Univariable analyses matched patient groups unveiled several independent prognostic factors CSS, including sex, age, marital status, tumor location, size, pathologic grade, historic staging, modality. Among these factors, being female, married, receiving emerged protective age exceeding 75 years, non-superior segment size greater than 6 cm, Grade 3-4 pathology, regional staging all found be factors. advantage over alone was substantial. Conclusions This investigation furnishes compelling evidence integration confers noteworthy when contrasted conventional grappling carcinoma.

Язык: Английский

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Crotonylation-Related Prognostic Model of Esophageal Squamous Cell Carcinoma Based on Transcriptome Analysis and Single-Cell Sequencing Analysis

International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 415 - 436

Опубликована: Янв. 1, 2025

Crotonylation is an emerging lysine acylation modification implicated in various diseases, yet its role esophageal squamous cell cancer (ESCC) unexplored. This study aimed to investigate the of crotonylation-related genes (CRGs) ESCC using bioinformatics approaches. We included three datasets and 24 CRGs. Differentially expressed (DEGs) from TCGA-ESCA were intersected with key module related CRGs identify candidate genes. Univariate LASSO regression analyses conducted select prognostic genes, which then used construct risk models. Independent analysis nomogram construction followed. Functional enrichment immune infiltration performed Single-cell was assess communication pseudotemporal dynamics cells. Intersection 1529 DEGs 1,048 yielded 55 OSM, FABP3, MICB, FAM189A2 identified as These classify ESCA patients into different groups a nomogram. FABP3 enriched neuroactive ligand-receptor interaction ribosome terms. MICB showed strong positive correlations natural killer T (NKT) cells, while negatively correlated gamma delta (γδT) mast cells neutrophils differentiating seven states, respectively. Four (OSM, FAM189A2) ESCC, potentially involved pathogenesis. OSM positively correlated.

Язык: Английский

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TFAP2A facilitates the metastasis and radioresistance of esophageal cancer by promoting EGFR transcription

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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