Geriatric Nutritional Risk Index is an effective prognostic predictor for metastatic/recurrent or unresectable esophageal cancer receiving immunotherapy DOI Open Access
Wang Bei, Zixuan Wang,

Chuanhai Xu

et al.

Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 16(1), P. 1 - 16

Published: Feb. 1, 2025

Immune checkpoint inhibitors (ICIs) have been extensively utilized in the treatment of esophageal squamous cell carcinoma (ESCC); however, patient responses to these therapies exhibit significant variability. This study aimed investigate prognostic value Geriatric Nutritional Risk Index (GNRI) patients with ESCC undergoing immunotherapy. A retrospective was conducted on 677 metastatic/recurrent or unresectable who received Kaplan-Meier analysis and Log-rank test compared survival differences between high low GNRI groups, while Cox proportional hazards models analyzed impact various subgroups identified independent factors. Furthermore, immunohistochemistry (IHC) performed endoscopic biopsy tissues from 45 disease immune ICIs as first-line treatments predictive performance combined programmed death ligand 1 (PD-L1) for tumor response overall (OS). Regardless status, levels had significantly longer OS time (P<0.001). Moreover, protective role observed subgroups. Eastern Cooperative Oncology Group status (ECOG PS) score, distant organ metastasis, previous treatments, ICI modalities were factors OS. may surpass that PD-L1 expression (P=0.009 vs. P=0.38), excelled predicting (P=0.007 P=0.08). The combination two indicators effectively predicted both (P=0.04) (P=0.03) serves a robust indicator are treated ICIs. integration demonstrates

Language: Английский

RSK2-mediated phosphorylation and degradation of UBE2O inhibits hepatocellular carcinoma growth and resistance to radiotherapy DOI Creative Commons
Yumei Huang, Anchen Qiu,

Yimei Meng

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217558 - 217558

Published: Feb. 1, 2025

Language: Английский

Citations

2
Inflammation in cancer: therapeutic opportunities from new insights DOI Creative Commons
Yifei Xie, Fangfang Liu, Yunfei Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 24, 2025

As one part of the innate immune response to external stimuli, chronic inflammation increases risk various cancers, and tumor-promoting is considered enabling characteristics cancer development. Recently, there has been growing evidence on role anti-inflammation therapy in prevention treatment. And researchers have already achieved several noteworthy outcomes. In review, we explored underlying mechanisms by which affects occurrence development cancer. The pro- or anti-tumor effects these inflammatory factors such as interleukin, interferon, chemokine, inflammasome, extracellular matrix are discussed. Since FDA-approved drugs like aspirin show obvious effects, unique advantages due their relatively fewer side with long-term use compared chemotherapy drugs. make them promising candidates for chemoprevention. Overall, this review discusses molecules carcinogenesis new molecules-directed therapeutic opportunities, ranging from cytokine inhibitors/agonists, inflammasome inhibitors, some inhibitors that expected be applied clinical practice, well recent discoveries effect non-steroidal anti-inflammatory steroidal disadvantages application chemoprevention also

Language: Английский

Citations

2
Octadecyl Gallate and Lipid‐Modified MnSe2 Nanoparticles Enhance Radiosensitivity in Esophageal Squamous Cell Carcinoma and Promote Radioprotection in Normal Tissues DOI
Xinyue Li, He Liu, Wenyan Gao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 26, 2024

Abstract Radiotherapy, a widely used therapeutic strategy for esophageal squamous cell carcinoma (ESCC), is always limited by radioresistance of tumor tissues and side‐effects on normal tissues. Herein, signature based four core genes cyclic GMP‐AMP synthase‐stimulator interferon (cGAS‐STING) pathway, developed to predict prognosis assess immune infiltration, indicating that the cGAS‐STING pathway radiotherapy efficacy are closely intertwined in ESCC. A novel lipid‐modified manganese diselenide nanoparticle (MnSe 2 ‐lipid) with extraordinarily uniform sphere morphology microenvironment (TME) responsiveness simultaneously overcome reduce radiation. The MnSe encapsulated lipid effectively achieves accumulation. Octadecyl gallate surface forming pH‐responsive metal–phenolic covalent realizes rapid degradation TME. released Mn 2+ promotes radiosensitivity generating reactive oxygen species induced Fenton‐like reaction activating pathway. Spontaneously, selenium strengthens response promoting secretion cytokines increasing white blood cells, performs antioxidant activity radiotherapy. Overall, this multifunctional remedy which responsive TME capable providing pathway‐mediated immunostimulation chemodynamic therapy, radioprotection tissues, highlighted here optimize ESCC treatment.

Language: Английский

Citations

12
A Self‐Catalytic NO/O2 Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief DOI Open Access
Shuyu Wang,

Miaomiao Cheng,

Shenghui Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted "prosthetic-Arginine" coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O

Language: Английский

Citations

12
The Cancer Antioxidant Regulation System in Therapeutic Resistance DOI Creative Commons

Xuanhao Gu,

Chunyang Mu,

Rujia Zheng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 778 - 778

Published: June 27, 2024

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cells adeptly maintain elevated levels both ROS and antioxidants through process termed "redox reprogramming". This balance optimizes proliferative influence while simultaneously reducing potential for cause damage cell. some cases, adapted antioxidant machinery can hamper efficacy treatments neoplastic diseases, representing significant facet resistance mechanisms observed therapy. this review, we outline contribution systems therapeutic resistance. We detail fundamental constituents these systems, encompassing central regulatory involving transcription factors (of particular importance is KEAP1/NRF2 signaling axis), molecular effectors antioxidants, auxiliary responsible NADPH generation. Furthermore, present recent clinical trials based on targeted treatment cancer, assessing as well challenges strategy Additionally, summarize pressing issues field, with aim illuminating path toward emergence novel anticancer approaches by orchestrating redox signaling.

Language: Английский

Citations

11
Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors DOI Creative Commons

Longyang Cao,

Hong Ouyang

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 23, 2024

Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, lipids can serve as messengers for intercellular communication. They play critical roles in the exchange information between tumor cells microenvironment (TME). The TME consists mesenchymal components extracellular matrix (ECM), fibroblasts being most abundant cell type mesenchyme. Cancer-associated (CAFs) derived from normal stem that activated TME. CAFs secrete exosomes to modulate proliferation, invasion, migration, drug resistance, other biological processes tumors. Additionally, manipulate function behavior through direct cell-cell interactions. This review provides summary crosstalk GI exosomes, along potential underlying mechanisms.

Language: Английский

Citations

8
Epithelial–mesenchymal transition to Mitigate Age-Related Progression in Lung Cancer DOI
Riya Thapa,

Saurabh Gupta,

Gaurav Gupta

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102576 - 102576

Published: Nov. 7, 2024

Language: Английский

Citations

8
Enhancing X‐Ray Sensitization with Multifunctional Nanoparticles DOI Creative Commons
Jiayi Liu, Junyong Wu, Taili Chen

et al.

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: April 26, 2024

Abstract In the progression of X‐ray‐based radiotherapy for treatment cancer, incorporation nanoparticles (NPs) has a transformative impact. This study investigates potential NPs, particularly those comprised high atomic number elements, as radiosensitizers. aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications NPs in encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along contributions photodynamic/photothermal therapy, imaging enhancement, integration artificial intelligence technology. Despite promising preclinical outcomes, paper acknowledges challenges clinical translation these findings. conclusion maintains an optimistic stance, emphasizing ongoing trials technological advancements that bolster personalized approaches. advocates continuous research validation, envisioning revolutionary paradigm cancer ultimately enhancing patient outcomes.

Language: Английский

Citations

7
Unraveling the complexities of colorectal cancer and its promising therapies – An updated review DOI

Sayan Saha,

Shreya Ghosh, Suman Ghosh

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113325 - 113325

Published: Oct. 14, 2024

Language: Английский

Citations

7
Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database DOI Creative Commons

Liangyun Xie,

Zhi Zhang

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 16, 2024

Background While simultaneous chemoradiotherapy remains the established therapeutic modality for patients afflicted with locally advanced esophageal cancer, effectiveness of this radical approach falls short desired outcome. Numerous investigations have illuminated prospect enhancing efficacy through amalgamation and immunotherapeutic interventions. Consequently, we embarked on an examination to scrutinize potential survival advantages conferred by confluence immunotherapy in relation unresectable carcinoma, drawing upon extensive SEER database our analysis. Methods We extracted clinicopathological attributes statistics diagnosed within temporal span encompassing years 2004-2014 2019-2020, from database. To discern disparities both overall (OS) cancer-specific (CSS) between cohorts subjected combined alone, employed analytical tools such as Kaplan-Meier analysis, Log-rank test, Cox regression proportional risk model, propensity-matched score (PSM) methodology. Results A total 7,758 eligible were encompassed research, 6,395 individuals having undergone while 1,363 received treatment immunotherapy. After 1:4 propensity matching, 6,447 successfully harmonized, yielding a well-balanced cohort. The curves demonstrated substantial enhancement OS (P = 0.0091) CSS &lt; 0.001) group compared alone. Further multivariable analysis PSM confirmed that benefits OS(HR=0.89, 95% CI 0.81-0.98) (HR=0.68, 0.61-0.76). In addition, Univariable analyses matched patient groups unveiled several independent prognostic factors CSS, including sex, age, marital status, tumor location, size, pathologic grade, historic staging, modality. Among these factors, being female, married, receiving emerged protective age exceeding 75 years, non-superior segment size greater than 6 cm, Grade 3-4 pathology, regional staging all found be factors. advantage over alone was substantial. Conclusions This investigation furnishes compelling evidence integration confers noteworthy when contrasted conventional grappling carcinoma.

Language: Английский

Citations

5