The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges

Essays in Biochemistry, Год журнала: 2025, Номер 69(02)

Опубликована: Март 7, 2025

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a crucial component the host's innate immunity and plays central role in detecting cytosolic double-stranded DNA from endogenous exogenous sources. Upon activation, cGAS synthesizes cGAMP, which binds to STING, triggering cascade immune responses, including production type I interferons pro-inflammatory cytokines. In context cancers, cGAS-STING can exert dual roles: on one hand, it promotes anti-tumor by enhancing antigen presentation, stimulating T-cell inducing direct tumor cell apoptosis. On other chronic particularly tumors with chromosomal instability, lead suppression progression. Persistent signaling results up-regulation checkpoint molecules such as PD-L1, contributing evasion metastasis. Consequently, strategies targeting have consider balance activation tolerance caused activation. This review explores mechanisms underlying both protumor roles pathway, focus potential therapeutic approaches, challenges faced their clinical application, along corresponding solutions.

Язык: Английский

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Nano-Delivery of STING Agonists: Unraveling the Potential of Immunotherapy

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Engineered tantalum sulfide nanosheets for effective acute liver injury treatment by regulating oxidative stress and inflammation

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137596 - 137596

Опубликована: Апрель 1, 2025

Язык: Английский

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STING Inhibitors and Degraders: Potential Therapeutic Agents in Inflammatory Diseases

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 291, С. 117632 - 117632

Опубликована: Апрель 15, 2025

Язык: Английский

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