The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)

Published: March 7, 2025

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a crucial component the host's innate immunity and plays central role in detecting cytosolic double-stranded DNA from endogenous exogenous sources. Upon activation, cGAS synthesizes cGAMP, which binds to STING, triggering cascade immune responses, including production type I interferons pro-inflammatory cytokines. In context cancers, cGAS-STING can exert dual roles: on one hand, it promotes anti-tumor by enhancing antigen presentation, stimulating T-cell inducing direct tumor cell apoptosis. On other chronic particularly tumors with chromosomal instability, lead suppression progression. Persistent signaling results up-regulation checkpoint molecules such as PD-L1, contributing evasion metastasis. Consequently, strategies targeting have consider balance activation tolerance caused activation. This review explores mechanisms underlying both protumor roles pathway, focus potential therapeutic approaches, challenges faced their clinical application, along corresponding solutions.

Language: Английский

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Nano-Delivery of STING Agonists: Unraveling the Potential of Immunotherapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Engineered tantalum sulfide nanosheets for effective acute liver injury treatment by regulating oxidative stress and inflammation

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137596 - 137596

Published: April 1, 2025

Language: Английский

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STING Inhibitors and Degraders: Potential Therapeutic Agents in Inflammatory Diseases

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 291, P. 117632 - 117632

Published: April 15, 2025

Language: Английский

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