Statins for the treatment of COVID-19 patients: an updated meta-analysis of randomized controlled trials DOI Creative Commons

Fatemeh Movahed,

Ehsan Heidari,

Masoud Dehbozorgi

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Окт. 15, 2024

Statin is a low-cost and easily accessible therapeutic option for COVID-19 patients. Previous observational studies meta-analyses suggest using statins Databases including Medline, Scopus, Embase, Cochrane Library, clinicaltrials.gov were systematically searched. After screening 754 records, 9 trials included. Overall, the study demonstrated non-significant reduction in all-cause mortality (p = 0.14, RR 0.90, 95% CI 0.79–1.03), no significant difference need mechanical ventilation 0.62, 0.95, 0.77–1.17), length of hospitalization 0.71, MD − 0.17 (95% 1.09, 0.76)). The certainty evidence varied across outcomes, with most demonstrating reasonable certainty. Our did not support clinical efficacy treatment COVID-19.

Язык: Английский

Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology DOI Creative Commons
Matthew Halma, Paul E. Marik,

Yusuf M. Saleeby

и другие.

Endocrine and Metabolic Science, Год журнала: 2024, Номер 14, С. 100163 - 100163

Опубликована: Янв. 30, 2024

Fasting, a practice with historical roots in various cultures, has recently garnered significant interest the field of medicine. In this article, we delve into mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore potential fasting on protein-related pathology role interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, metformin. conclusion, fasting, coupled an understanding nuances, holds promise as intervention SARS-CoV-2 related diseases; broad implications human health. This review presents possibility using treat diseases, details deploy modality.

Язык: Английский

Процитировано

3
Perturbed Lipid Metabolism Transduction Pathways in SARS-CoV-2 Infection and Their Possible Treating Nutraceuticals DOI
Amrita Shukla, Ankita Singh, Smriti Tripathi

и другие.

Journal of the American Nutrition Association, Год журнала: 2024, Номер 43(7), С. 614 - 626

Опубликована: Май 28, 2024

The coronavirus disease 2019 (COVID-19) epidemic has evolved into an international public health concern. Its causing agent was SARS-CoV-2 (severe acute respiratory syndrome 2), a lipid bilayer encapsulated virus. Lipids have relevance in the host's viral cycle; additionally; viruses been speculated to manipulate signaling and production influence lipidome of host cells. engages pathways for replication, like fatty acid synthesis activation via upregulation AKT SREBP pathway inhibiting catabolism by AMPK PPAR deactivation. Consequently, lipoprotein levels are altered most cases, i.e., raised LDL, TG, VLDL reduced HDL hyperlipidemic state. Apo lipoproteins, subsiding structural part may also impact spike protein binding cell receptors. In few studies conducted on COVID-19 patients, maintaining shown antiviral activity against infection. It that several potent hypolipidemic drugs, such as statins, hydroxychloroquine, metformin, could be used add-on treatment management. Nutraceuticals Garlic, Fenugreek, vinegar potency lower capability acting these pathways. A link between post-COVID alteration not yet fully understood. this review, we try look over possible modifications metabolism due exposure, besides prospect focusing potential metabolic processes interrupt cycle.

Язык: Английский

Процитировано

2
Lipid compartments and lipid metabolism as therapeutic targets against coronavirus DOI Creative Commons

Daniella Cesar-Silva,

Filipe S. Pereira‐Dutra, Ana L.M. Giannini

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Дек. 1, 2023

Lipids perform a series of cellular functions, establishing cell and organelles’ boundaries, organizing signaling platforms, creating compartments where specific reactions occur. Moreover, lipids store energy act as secondary messengers whose distribution is tightly regulated. Disruption lipid metabolism associated with many diseases, including those caused by viruses. In this scenario, can favor virus replication are not solely used pathogens’ source. contrast, cells counteract viruses using weapons. review, we discuss the available data on how coronaviruses profit from why targeting may be powerful strategy to fight these parasites. We also provide formidable collection pharmacological approaches impair treat coronavirus infection.

Язык: Английский

Процитировано

6
Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection DOI Creative Commons
Kusha Mohammadi, Mark W. Sleeman, Anita Boyapati

и другие.

Journal of Lipid Research, Год журнала: 2024, Номер 65(6), С. 100568 - 100568

Опубликована: Май 23, 2024

Plasma lipid levels are modulated by systemic infection and inflammation; it is unknown whether these changes reflect inflammatory responses or caused directly pathogen presence. We explored the hypothesis that anti-inflammatory intervention via interleukin 6 receptor (IL-6R) blockade would influence plasma during severe evaluated association of with clinical outcomes. Sarilumab (monoclonal antibody blocking IL-6R) efficacy was previously assessed in patients coronavirus disease 2019 (COVID-19) (NCT04315298). This analysis determined strong reduction sarilumab COVID-19 pneumonia increasing severity (severe, critical, multisystem organ dysfunction) affected between day 1 7 study therapy. Baseline reflected presence acute infection, characterized very low HDL-C, LDL-C, moderately elevated triglycerides (TGs). Disease associated progressively more abnormal levels. At 7, median increased versus placebo group (HDL-C +10.3%, LDL-C +54.7%, TG +32% vs. HDL-C +1.7%, +15.4%, +8.8%, respectively). No significant outcomes observed. In conclusion, severe-to-critical causes profound depression only modestly responsive to anti-IL-6R intervention. Conversely, strongly IL-6R blockade, likely returning predisease set point. These results advance our understanding complex relationship serum lipids infection/inflammation suggest contagious driven not IL-6-mediated inflammation.

Язык: Английский

Процитировано

1
Statins for the treatment of COVID-19 patients: an updated meta-analysis of randomized controlled trials DOI Creative Commons

Fatemeh Movahed,

Ehsan Heidari,

Masoud Dehbozorgi

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Окт. 15, 2024

Statin is a low-cost and easily accessible therapeutic option for COVID-19 patients. Previous observational studies meta-analyses suggest using statins Databases including Medline, Scopus, Embase, Cochrane Library, clinicaltrials.gov were systematically searched. After screening 754 records, 9 trials included. Overall, the study demonstrated non-significant reduction in all-cause mortality (p = 0.14, RR 0.90, 95% CI 0.79–1.03), no significant difference need mechanical ventilation 0.62, 0.95, 0.77–1.17), length of hospitalization 0.71, MD − 0.17 (95% 1.09, 0.76)). The certainty evidence varied across outcomes, with most demonstrating reasonable certainty. Our did not support clinical efficacy treatment COVID-19.

Язык: Английский

Процитировано

0