ACS Nano,
Год журнала:
2024,
Номер
18(17), С. 10979 - 11024
Опубликована: Апрель 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Advances in Materials Science and Engineering,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
The
sol‐gel
process
is
a
more
chemical
method
(wet
method)
for
the
synthesis
of
various
nanostructures,
especially
metal
oxide
nanoparticles.
In
this
method,
molecular
precursor
(usually
alkoxide)
dissolved
in
water
or
alcohol
and
converted
to
gel
by
heating
stirring
hydrolysis/alcoholysis.
Since
obtained
from
hydrolysis/alcoholysis
wet
damp,
it
should
be
dried
using
appropriate
methods
depending
on
desired
properties
application
gel.
For
example,
if
an
alcoholic
solution,
drying
done
burning
alcohol.
After
stage,
produced
gels
are
powdered
then
calcined.
cost‐effective
due
low
reaction
temperature
there
good
control
over
composition
products.
can
used
making
ceramics
as
molding
material
intermediate
between
thin
films
oxides
applications.
materials
optical,
electronic,
energy,
surface
engineering,
biosensors,
pharmaceutical
separation
technologies
(such
chromatography).
conventional
industrial
nanoparticles
with
different
composition.
basis
production
homogeneous
sol
precursors
its
conversion
into
solvent
removed
structure
remaining
dried.
depend
significantly
method.
other
words,
“removing
method”
selected
according
which
will
used.
Dried
ways
industries
such
coating,
building
insulation,
special
clothing.
It
worth
mentioning
that,
grinding
mills,
possible
achieve
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
Frontiers in Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 3, 2022
Virus-like
particles
(VLPs)
are
nanostructures
that
possess
diverse
applications
in
therapeutics,
immunization,
and
diagnostics.
With
the
recent
advancements
biomedical
engineering
technologies,
commercially
available
VLP-based
vaccines
being
extensively
used
to
combat
infectious
diseases,
whereas
many
more
different
stages
of
development
clinical
studies.
Because
their
desired
characteristics
terms
efficacy,
safety,
diversity,
approaches
might
become
recurrent
years
come.
However,
some
production
fabrication
challenges
must
be
addressed
before
can
widely
therapeutics.
This
review
offers
insight
into
development,
with
an
emphasis
on
characteristics,
expression
systems,
potential
applicability
as
ideal
candidates
emerging
virulent
pathogens.
Finally,
vaccine
viable
efficient
immunizing
agents
induce
immunity
against
agents,
including,
SARS-CoV-2
protein
nanoparticle-based
has
been
elaborated.
Thus,
VLP
may
serve
effective
alternative
conventional
strategies
combating
diseases.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
International Journal of Nanomedicine,
Год журнала:
2022,
Номер
Volume 17, С. 3735 - 3749
Опубликована: Авг. 1, 2022
Abstract:
Cancer
remains
the
most
devastating
disease
and
major
cause
of
mortality
worldwide.
Although
early
diagnosis
treatment
are
key
approach
in
fighting
against
cancer,
available
conventional
diagnostic
therapeutic
methods
not
efficient.
Besides,
ineffective
cancer
cell
selectivity
toxicity
traditional
chemotherapy
remain
significant
challenge.
These
limitations
entail
need
for
development
both
safe
effective
options.
Due
to
its
robust
application,
nanotechnology
could
be
a
promising
method
in-vivo
imaging
detection
cells
biomarkers.
Nanotechnology
provide
quick,
safe,
cost-effective,
efficient
management.
It
also
provides
simultaneous
using
nano-theragnostic
particles
that
facilitate
selective
destruction
cells.
Updated
recent
discussions
important
selecting
best
diagnosis,
treatment,
management
options,
new
insights
on
designing
protocols
utmost
important.
This
review
discusses
application
therapeutics,
theragnosis
future
perspectives
field.
Keywords:
nanotechnology,
theragnostics
Pharmaceuticals,
Год журнала:
2023,
Номер
16(10), С. 1410 - 1410
Опубликована: Окт. 4, 2023
Metal
nanoparticles
(NPs)
have
garnered
considerable
attention,
due
to
their
unique
physicochemical
properties,
that
render
them
promising
candidates
for
various
applications
in
medicine
and
industry.
This
article
offers
a
comprehensive
overview
of
the
most
recent
advancements
manufacturing,
characterization,
biomedical
utilization
metal
NPs,
with
primary
focus
on
silver
gold
NPs.
Their
potential
as
effective
anticancer,
anti-inflammatory,
antimicrobial
agents,
drug
delivery
systems,
imaging
agents
diagnosis
treatment
variety
disorders
is
reviewed.
Moreover,
translation
therapeutic
settings,
issue
inclusion
clinical
trials,
are
assessed
light
over
30
investigations
concentrate
administering
either
or
NPs
conditions
ranging
from
nosocomial
infections
different
types
cancers.
paper
aims
not
only
examine
biocompatibility
nanomaterials
but
also
emphasize
challenges
may
limit
safe
integration
into
healthcare
practices.
More
than
100
nanomedicines
currently
market,
which
justifies
ongoing
study
use
medicine.
Overall,
present
review
highlight
innovative
therapeutics
field
biomedicine,
citing
some
relevant
current
applications.
