Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 417 - 438
Опубликована: Янв. 1, 2025
Язык: Английский
RSC Advances, Год журнала: 2024, Номер 14(19), С. 13535 - 13564
Опубликована: Янв. 1, 2024
Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.
Язык: Английский
Процитировано
34
Biomimetics, Год журнала: 2024, Номер 9(3), С. 154 - 154
Опубликована: Март 1, 2024
The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.
Язык: Английский
Процитировано
17
Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 126955 - 126955
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Янв. 22, 2025
Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.
Язык: Английский
Процитировано
2
Talanta, Год журнала: 2024, Номер 280, С. 126790 - 126790
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
13
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 206 - 206
Опубликована: Фев. 14, 2024
Skin grafting is a helpful instrument in plastic surgeon's arsenal. Several types of dressings were designed to facilitate the process graft integration. Negative-pressure wound therapy proven dressing method, enhancing survival through several mechanisms: aspiration secretions, stimulation neoangiogenesis, and promotion an anti-inflammatory environment. Silver nanoparticle also bring multiple benefits by bearing antimicrobial effect providing humid medium, which are favorable for epithelialization. The combination NPWT (negative-pressure therapy) with AgNPs (silver nanoparticles) has not been widely studied.
Язык: Английский
Процитировано
11
Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1134 - 1134
Опубликована: Авг. 29, 2024
The increasing threat from antibiotic-resistant bacteria has necessitated the development of novel methods to counter bacterial infections. In this context, application metallic nanoparticles (NPs), especially gold (Au) and silver (Ag), emerged as a promising strategy due their remarkable antibacterial properties. This review examines research published between 2006 2023, focusing on leading journals in nanotechnology, materials science, biomedical research. primary applications explored are efficacy Ag Au NPs agents, synthesis methods, morphological properties, mechanisms action. An extensive literature synthesis, morphology, minimum inhibitory concentration (MIC), bactericidal (MBC), effectiveness against various Gram(+/-) confirms NPs. characteristics NPs, such size, shape, surface charge, crucial determining activity, these factors influence interactions with cells. Furthermore, underscores urgent necessity standardizing techniques, MICs, reporting protocols enhance comparability reproducibility future studies. Standardization is essential for ensuring reliability findings accelerating clinical NP-based antimicrobial approaches. aims propel strategies by elucidating properties that activity By highlighting effects strains relatively low cytotoxicity, work positions developing making significant contribution global efforts combat pathogens.
Язык: Английский
Процитировано
11
The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 174940 - 174940
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
8
Archives of Toxicology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
1
Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 115998 - 115998
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1