pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(2), С. 3194 - 3207

Опубликована: Янв. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Язык: Английский

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What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(19), С. 10799 - 10799

Опубликована: Окт. 6, 2021

Oxygen in the atmosphere is a crucial component for life-sustaining aerobic respiration humans. Approximately 95% of oxygen consumed as energy and ultimately becomes water; however, remaining 5% produces metabolites called activated or reactive species (ROS), which are extremely reactive. Skin, largest organ human body, exposed to air pollutants, including diesel exhaust fumes, ultraviolet rays, food, xenobiotics, drugs, cosmetics, promote production ROS. ROS exacerbate skin aging inflammation, but also function regulators homeostasis epidermal keratinocyte proliferation. Although have been implicated various diseases, underlying mechanisms not yet elucidated. Current knowledge on ROS-related oxidative stress-related diseases from basic research clinical treatment strategies discussed herein. This information may be applied future through individual targeting generated each case via their inhibition, capture, regulation.

Язык: Английский

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All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Chemical Engineering Journal, Год журнала: 2022, Номер 439, С. 135691 - 135691

Опубликована: Март 9, 2022

Язык: Английский

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Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

Bioactive Materials, Год журнала: 2022, Номер 17, С. 49 - 70

Опубликована: Фев. 1, 2022

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment motor system injury, digestive disease, oculopathy, bioelectronics. In this review, starting with the classification common hydrogels, pyramid evolution process from structures derived then applications is elaborated, well efficient reverse design considerations hydrogel systems are proposed. Finally, existing problems development prospects these materials discussed. It hoped that perspective review can promote further innovation breakthroughs future.

Язык: Английский

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Advances in modified hyaluronic acid-based hydrogels for skin wound healing

Biomaterials Science, Год журнала: 2022, Номер 10(13), С. 3393 - 3409

Опубликована: Янв. 1, 2022

Overview of crosslinking strategies hyaluronic acid-based hydrogels and their applications in skin wound healing.

Язык: Английский

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pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Янв. 4, 2022

The management of diabetic ulcer (DU) to rescue stalled wound healing remains a paramount clinical challenge due the spatially and temporally coupled pathological microenvironment that features hyperglycemia, biofilm infection, hypoxia excessive oxidative stress. Here we present pH-switchable nanozyme cascade catalysis (PNCC) strategy for spatial-temporal modulation in DU. PNCC is demonstrated by employing clinically approved iron oxide nanoparticles coated with shell glucose oxidase (Fe3O4-GOx). Fe3O4-GOx possesses intrinsic (GOx), catalase (CAT) peroxidase (POD)-like activities, can catalyze glucose-initiated GOx/POD GOx/CAT reaction acidic neutral environment, respectively. Specifically, generating consecutive fluxes toxic hydroxyl radical targets (pH ~ 5.5), eradicates shorten inflammatory phase initiate normal processes. Furthermore, producing oxygen tissue, accelerates proliferation remodeling phases addressing issues hypoxia, shortened accelerated significantly speed up orchestrated wound-healing cascades. Remarkably, this Fe3O4-GOx-instructed DU enables complete re-epithelialization biofilm-infected mice within 15 days while minimizing toxicity tissues, exerting great transformation potential management. proposed concept offers new perspective complex remodeling, may provide powerful modality treatment microenvironment-associated diseases.

Язык: Английский

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Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Апрель 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Язык: Английский

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Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression

Bioactive Materials, Год журнала: 2022, Номер 19, С. 653 - 665

Опубликована: Май 11, 2022

Wound healing is one of the major global health concerns in patients with diabetes. Overactivation pro-inflammatory M1 macrophages associated delayed wound miR-29ab1 plays a critical role diabetes-related macrophage inflammation. Hence, inhibition inflammation and regulation miR-29 expression have been implicated as new points for skin healing. In this study, traditional Chinese medicine, puerarin, was introduced to construct an injectable self-healing chitosan@puerarin (C@P) hydrogel. The C@P hydrogel promoted diabetic accelerated angiogenesis, which were related mediated response. Compared healthy subjects, miR-29a miR-29b1 ectopically increased model, accompanied by upregulated M1-polarization, elevated levels IL-1β TNF-α. Further evaluations knockout mice exhibited superior attenuated present results suggested that essential regulating inflammatory Suppression has potential improving medical approaches repair.

Язык: Английский

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Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

Materials Today Bio, Год журнала: 2022, Номер 15, С. 100264 - 100264

Опубликована: Апрель 20, 2022

Polydopamine nanoparticles (PDA NPs) are an appealing biomimetic photothermal agent for antibacterial treatment because of their long-term safety, excellent photostability, accessible manufacturing, and good biodegradability. However, the low conversion efficiency (PCE) PDA NPs requires high-power near-infrared light irradiation, which severely restricts practical application. In this work, PDA@Cu were fabricated by growing Cu in situ on surface then introduced into a polyelectrolyte hydrogel precursor (cationic polyethyleneimine/anionic pectin, named as CPAP). The formulated platform possessed high PCE (55.4%), almost twice much pure (30.8%). Moreover, designed CPAP/PDA@Cu captured killed some bacteria electrostatic adsorption, helped enhance performance. As expected, formed that combined advantageous features (high PCE) CPAP matrix (inherent activity preventing aggregation) can efficiently kill both vitro vivo under help laser irradiation. Taken together, study offers promising strategy constructing facile safe PDA-based therapy.

Язык: Английский

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Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(9), С. 4055 - 4085

Опубликована: Авг. 18, 2022

Currently, the clinic's treatment of acute/chronic wounds is still unsatisfactory due to lack functional and appropriate wound dressings. Intelligent multifunctional dressings are considered most advanced modalities. It essential design develop with required functions according microenvironment in clinical treatment. This work summarizes characteristics various common wounds, such as acute wound, diabetic burns scalded mucosal ulcers wound. Furthermore, factors transformation from chronic were analyzed. Then we focused on summarizing how researchers fully thoroughly combined complex modern technology ensure usability value dressing, photothermal-sensitive dressings, dressing (pH-sensitive ROS-sensitive osmotic pressure dressings), hemostatic guiding tissue regeneration microneedle 3D/4D printing Finally, revolutionary development transform existing into needs soon possible have carried out a reasonable meaningful outlook.

Язык: Английский

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