Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(9)
Опубликована: Янв. 21, 2024
Abstract
The
complex
preparation,
weak
wet
tissue
adhesion,
and
limited
biological
activity
of
traditional
oral
wound
dressings
usually
impede
their
efficient
treatment
healing
for
diabetic
mucosal
defects.
To
overcome
these
problems,
a
novel
hydrogel
adhesive
(named
CFT
hydrogel)
is
rapidly
constructed
using
one‐step
method
based
on
dual‐dynamic
covalent
cross‐linking.
Compared
with
the
commercial
patches,
shows
superior
in
vivo
(rat
tongue)
adhesion
performance.
Additionally,
exhibits
unique
acid‐responsive
properties,
thereby
facilitating
release
bioactive
molecule
tannic
acid
acidic
microenvironment.
And
series
vitro
experiments
substantiate
favorable
biocompatibility
bioactivity
properties
(including
antibacterial,
antioxidative,
anti‐inflammatory,
angiogenetic
effects)
exhibited
by
hydrogel.
Moreover,
conducted
rat
model
defects
demonstrate
that
significant
efficacy
protecting
against
wounds,
alleviating
inflammatory
reactions,
wound‐healing
process.
Taken
together,
this
study
provides
promising
comprehensive
therapeutic
option
great
potential
clinical
management
mucosa
patients.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 23, 2024
Abstract
Wound
healing
is
an
obvious
clinical
concern
that
can
be
hindered
by
inadequate
angiogenesis,
inflammation,
and
chronic
hypoxia.
While
exosomes
derived
from
adipose
tissue-derived
stem
cells
have
shown
promise
in
accelerating
carrying
therapeutic
growth
factors
microRNAs,
intracellular
cargo
delivery
compromised
hypoxic
tissues
due
to
activated
hypoxia-induced
endocytic
recycling.
To
address
this
challenge,
we
developed
a
strategy
coat
oxygen
nanobubbles
with
incorporate
them
into
polyvinyl
alcohol/gelatin
hybrid
hydrogel.
This
approach
not
only
alleviates
wound
hypoxia
but
also
offers
efficient
means
of
delivering
exosome-coated
nanoparticles
conditions.
The
self-healing
properties
the
hydrogel,
along
its
component,
gelatin,
aids
hemostasis,
while
crosslinking
bonds
facilitate
hydrogen
peroxide
decomposition,
ameliorate
inflammation.
Here,
show
potential
multifunctional
hydrogel
for
enhanced
healing,
promoting
facilitating
exosome
delivery,
mitigating
hypoxia,
inhibiting
inflammation
male
rat
full-thickness
model.
Abstract
Reactive
oxygen
species
play
a
crucial
role
in
cell
signaling
pathways
during
wound
healing
phases.
Treatment
strategies
to
balance
the
redox
level
deep
tissue
are
emerging
for
management.
In
recent
years,
reactive
scavenging
agents
including
natural
antioxidants,
(ROS)
nanozymes,
and
antioxidant
delivery
systems
have
been
widely
employed
inhibit
oxidative
stress
promote
skin
regeneration.
Here,
importance
of
different
phases
is
critically
analyzed.
Various
cutting‐edge
bioactive
ROS
nanoscavengers
platforms
discussed.
This
review
also
highlights
future
directions
therapies
via
scavenging.
comprehensive
offers
map
research
on
scavengers
with
balancing
mechanisms
action
process,
which
benefits
development
clinical
applications
next‐generation
scavenging‐based
nanomaterials
Advanced Materials,
Год журнала:
2023,
Номер
35(40)
Опубликована: Июнь 21, 2023
Abstract
Engineered
skin
substitutes
derived
from
human
significantly
reduce
inflammatory
reactions
mediated
by
foreign/artificial
materials
and
are
consequently
easier
to
use
for
clinical
application.
Type
I
collagen
is
a
main
component
of
the
extracellular
matrix
during
wound
healing
has
excellent
biocompatibility,
platelet‐rich
plasma
can
be
used
as
initiator
cascade.
Adipose
mesenchymal
stem
cell
exosomes
crucial
tissue
repair
play
key
roles
in
enhancing
regeneration,
promoting
angiogenesis,
regulating
inflammation,
remodeling
matrix.
Herein,
plasma,
which
provide
natural
supports
keratinocyte
fibroblast
adhesion,
migration,
proliferation,
mixed
form
stable
3D
scaffold.
added
scaffold
improve
performance
engineered
skin.
The
physicochemical
properties
this
cellular
analyzed,
effect
evaluated
full‐thickness
defect
mouse
model.
reduces
level
inflammation
promotes
proliferation
angiogenesis
accelerate
healing.
Proteomic
analysis
shows
that
exhibit
anti‐inflammatory
proangiogenic
effects
collagen/platelet‐rich
scaffolds.
proposed
method
provides
new
therapeutic
strategy
theoretical
basis
regeneration
repair.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 14, 2023
Injuries
to
our
skin
trigger
a
cascade
of
spatially-
and
temporally-synchronized
healing
processes.
During
such
endogenous
wound
repair,
the
role
fibroblasts
is
multifaceted,
ranging
from
activation
recruitment
innate
immune
cells
through
synthesis
deposition
scar
tissue
conveyor
belt-like
transport
fascial
connective
into
wounds.
A
comprehensive
understanding
fibroblast
diversity
versatility
in
machinery
may
help
decipher
pathologies
whilst
laying
foundation
for
novel
treatment
modalities.
In
this
review,
we
portray
delineate
their
unique
functions.
addition,
discuss
future
directions
clinical-translational
lens.
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 12, 2024
Zwitterionic
polymers
have
emerged
as
an
important
class
of
biomaterials
to
construct
wound
dressings
and
antifouling
coatings
over
the
past
decade
due
their
excellent
hydrophilicity.
However,
all
reported
zwitterionic
are
nondegradable
because
noncleavable
carbon─carbon
bonding
backbones,
must
be
removed
periodically
after
treatment
avoid
hypoxia
in
wound,
thus
leading
potential
secondary
injury.
In
this
work,
a
biodegradable
polyzwitterion
patch
is
fabricated
for
first
time
by
ring-opening
polymerization
carboxybetaine
dithiolane
(CBDS),
which
self-crosslinked
via
inter-amide
hydrogen
bonds
dipole-dipole
interactions
on
side
chains.
The
unprecedented
polyCBDS
(PCBDS)
demonstrates
enough
ductility
owing
intermolecular
physical
fully
cover
irregular
wounds,
also
showing
biodegradability
performance
resulted
from
existence
disulfide
groups.
Besides,
PCBDS
degradation-induced
released
CBDS
owns
potent
antioxidant
antibacterial
activities.
This
used
diabetic
dressing,
inhibiting
bacterial
adhesion
external
surface,
its
degradation
products
can
exactly
kill
bacteria
scavenge
excessive
reactive
oxygen
species
(ROS)
at
site
regulate
local
microenvironment,
including
regulation
cytokine
express
macrophage
polarization,
accelerating
infected
repair,
avoiding
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(2), С. 2140 - 2153
Опубликована: Янв. 5, 2024
Multivalent
ion
cross-linking
has
been
used
to
form
hydrogels
between
sodium
alginate
(SA)
and
hyaluronic
acid
(HA)
in
previous
studies.
However,
more
stable
robust
covalent
is
rarely
reported.
Herein,
we
present
a
facile
approach
fabricate
SA
HA
hydrogel
for
wound
dressings
with
injectable,
good
biocompatibility,
high
ductility.
was
first
reacted
ethylenediamine
graft
an
amino
group.
Then,
it
cross-linked
oxidized
dialdehyde
networks.
The
dressing
can
effectively
promote
cell
migration
healing.
To
increase
the
antibacterial
property
of
dressing,
successfully
loaded
tetracycline
hydrochloride
into
as
model
drug.
drug
be
released
slowly
alkaline
environment
chronic
wounds,
releases
drugs
again
acidic
healing,
achieving
long-term
effect.
In
addition,
one-dimensional
partial
differential
equations
based
on
Fickian
diffusion
time-varying
coefficients
thicknesses
were
entire
complex
release
process
predict
release.
