Biofilm,
Год журнала:
2025,
Номер
9, С. 100268 - 100268
Опубликована: Март 1, 2025
The
successful
sustainable
cultivation
of
the
well-known
medicinal
plant
sundew
on
rewetted
peatlands
not
only
leads
to
preservation
natural
populations,
but
also
provides
a
basis
for
pharmaceutical
use
plant.
bioactive
compounds
sundew,
flavonoids
and
naphthoquinones,
show
biofilm-inhibiting
properties
against
multidrug-resistant,
ESBL-producing
E.
coli
strains
open
up
new
therapeutic
possibilities.
This
study
investigates
molecular
mechanisms
these
in
biofilm
inhibition
through
proteomic
analyses.
Specific
fractions
as
well
individual
substances
like
7-methyljuglone
2″-O-galloylhyperoside,
are
analyzed.
Results
that
naphthoquinones
appear
act
via
central
regulatory
proteins
such
OmpR
alter
stress
response
while
likely
affect
formation
by
creating
an
iron-poor
environment
iron
complexation
additionally
influence
polyamine
balance,
reducing
intracellular
spermidine
levels.
Further
investigations
including
assays
analysis
polyamines
confirmed
data.
Safety
evaluations
cytotoxicity
tests
3D
cell
cultures
Galleria
mellonella
vivo
model
confirm
safety
extracts
used.
These
findings
highlight
promising
candidate
phytopharmaceuticals.
Molecules,
Год журнала:
2022,
Номер
27(19), С. 6545 - 6545
Опубликована: Окт. 3, 2022
Quercetin,
as
a
flavonol
compound
found
in
plants,
has
variety
of
biological
activities.
It
is
widely
present
nature
and
the
human
diet,
with
powerful
oxidative
properties
In
this
review,
antioxidant
mechanism
broad-spectrum
antibacterial
quercetin
are
revealed;
intervention
effects
on
pesticide
poisoning
pathway
action
investigated;
toxic
main
mycotoxins
collection
detoxification
process
summarized;
whether
it
able
to
reduce
toxicity
proved;
harmful
heavy
metal
collection,
prevention,
control
evaluated.
This
review
expected
enrich
understanding
promote
its
better
application
clinical
practice.
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 413 - 413
Опубликована: Янв. 31, 2023
The
wide
spread
of
antibiotic
resistance
has
been
alarming
in
recent
years
and
poses
a
serious
global
hazard
to
public
health
as
it
leads
millions
deaths
all
over
the
world.
sharing
genes
between
different
types
bacteria
led
emergence
multidrug
resistant
(MDR)
microorganisms.
This
problem
is
exacerbated
when
microorganisms
create
biofilms,
which
can
boost
bacterial
by
up
1000-fold
increase
MDR
infections.
absence
novel
potent
antimicrobial
compounds
linked
rise
resistance.
sparked
international
efforts
develop
new
improved
agents
well
innovative
efficient
techniques
for
administration
targeting.
There
an
evolution
nanotechnology
treatment
prevention
biofilm
formation
infection.
development
nanomaterial-based
therapeutics,
could
overcome
current
pathways
acquired
drug
resistance,
hopeful
strategy
treating
difficult-to-treat
Additionally,
nanoparticles’
distinct
size
physical
characteristics
enable
them
target
biofilms
treat
pathogens.
review
highlights
advances
combat
In
addition,
provides
insight
on
mechanisms
XDR
infection,
nanoparticles
their
antibacterial
activity.
Moreover,
this
considers
difference
free
antibiotics
nanoantibiotics,
synergistic
effect
nanoantibiotics
planktonic
bacteria,
intracellular
biofilm.
Finally,
we
will
discuss
strength
limitations
application
against
infection
future
perspectives.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 6, 2022
As
the
essential
regulators
of
organ
fibrosis,
macrophages
undergo
marked
phenotypic
and
functional
changes
after
injury.
These
in
macrophage
phenotype
function
can
result
maladaptive
repair,
causing
chronic
inflammation
development
pathological
fibrosis.
Autophagy,
a
highly
conserved
lysosomal
degradation
pathway,
is
one
major
players
to
maintain
homeostasis
through
clearing
protein
aggregates,
damaged
organelles,
invading
pathogens.
Emerging
evidence
has
shown
that
autophagy
plays
an
role
polarization,
inflammation,
Because
high
heterogeneity
different
organs,
types
may
play
roles
Here,
we
review
current
understanding
fibrosis
highlight
potential
treatment
Finally,
important
unresolved
issues
this
field
are
briefly
discussed.
A
better
mechanisms
contribute
developing
novel
therapies
for
inflammatory
diseases
Antioxidants,
Год журнала:
2023,
Номер
12(2), С. 280 - 280
Опубликована: Янв. 27, 2023
Neurological
and
neurodegenerative
diseases,
particularly
those
related
to
aging,
are
on
the
rise,
but
drug
therapies
rarely
curative.
Functional
disorders
organic
degeneration
of
nervous
tissue
often
have
complex
causes,
in
which
phenomena
oxidative
stress,
inflammation
cytotoxicity
intertwined.
For
these
reasons,
search
for
natural
substances
that
can
slow
down
or
counteract
pathologies
has
increased
rapidly
over
last
two
decades.
In
this
paper,
studies
neuroprotective
effects
flavonoids
(especially
most
widely
used,
hesperidin
quercetin)
animal
models
depression,
neurotoxicity,
Alzheimer’s
disease
(AD)
Parkinson’s
reviewed.
The
literature
topics
amounts
a
few
hundred
publications
vitro
vivo
(notably
rodents)
provides
us
with
very
detailed
picture
action
mechanisms
targets
substances.
These
include
decrease
enzymes
produce
reactive
oxygen
ferroptosis,
inhibition
mono-amine
oxidases,
stimulation
Nrf2/ARE
system,
induction
brain-derived
neurotrophic
factor
production
and,
case
AD,
prevention
amyloid-beta
aggregation.
neuroinflammatory
processes
been
documented
as
cytokine
formation
(mainly
TNF-alpha
IL-1beta)
by
microglia
astrocytes,
modulating
number
regulatory
proteins
such
Nf-kB
NLRP3/inflammasome.
Although
clinical
trials
humans
still
scarce,
preclinical
allow
consider
hesperidin,
quercetin,
other
interesting
safe
dietary
molecules
be
further
investigated
complementary
treatments
order
prevent
diseases
moderate
their
deleterious
effects.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1656 - 1656
Опубликована: Июнь 5, 2023
Quercetin
(QUE)
is
a
flavonol
that
has
recently
received
great
attention
from
the
research
community
due
to
its
important
pharmacological
properties.
However,
QUE's
low
solubility
and
extended
first-pass
metabolism
limit
oral
administration.
This
review
aims
present
potential
of
various
nanoformulations
in
development
QUE
dosage
forms
for
bioavailability
enhancement.
Advanced
drug
delivery
nanosystems
can
be
used
more
efficient
encapsulation,
targeting,
controlled
release
QUE.
An
overview
primary
nanosystem
categories,
formulation
processes,
characterization
techniques
are
described.
In
particular,
lipid-based
nanocarriers,
such
as
liposomes,
nanostructured-lipid
carries,
solid-lipid
nanoparticles,
widely
improve
absorption
increase
antioxidant
activity,
ensure
sustained
release.
Moreover,
polymer-based
nanocarriers
exhibit
unique
properties
improvement
Absorption,
Distribution,
Metabolism,
Excretion,
Toxicology
(ADME(T))
profile.
Namely,
micelles
hydrogels
composed
natural
or
synthetic
polymers
have
been
applied
formulations.
Furthermore,
cyclodextrin,
niosomes,
nanoemulsions
proposed
alternatives
administration
via
different
routes.
comprehensive
provides
insight
into
role
advanced
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Март 12, 2024
Abstract
Diabetes
mellitus
(DM)
is
characterized
by
elevated
blood
glucose
and
advanced
glycation
end
product
(AGEs)
levels.
Increased
AGEs
in
bone
tissue
inhibit
osteogenic
differentiation
marrow
mesenchymal
stem
cells
(BMSCs),
leading
to
loss
osteoporosis
diabetic
patients.
Enhancing
the
capacity
of
BMSCs
presence
abundant
can
improve
health
prevent
DM
The
flavonoid,
Quercetin,
has
anti‐inflammatory,
antibacterial,
antitumor
properties;
however,
it
insoluble
water
thus
not
easily
absorbed
body.
Nanodrug
delivery
systems
such
as
tetrahedral
framework
nucleic
acids
(tFNAs)
exhibit
excellent
biocompatibility,
efficient
cell
uptake,
drug
piggybacking.
In
present
study,
tFNAs
with
quercetin
complexed
form
a
novel
nanodrug
(tFNAs/Que)
that
combined
features
both
components.
tFNAs/Que
promote
an
vitro
AGEs‐rich
environment,
maintain
mass,
mice
vivo.
mechanism
against
may
be
related
JNK
signaling
pathway.
conclusion,
shown
dual
regulatory
role
promoting
inhibiting
apoptosis.
Such
feature
promising
for
prevention
treatment
osteoporosis.
ACS Nano,
Год журнала:
2024,
Номер
18(11), С. 7890 - 7906
Опубликована: Март 6, 2024
Ferroptosis
is
a
vital
driver
of
pathophysiological
consequences
Alzheimer's
disease
(AD).
High-efficiency
pharmacological
inhibition
ferroptosis
requires
comprehensive
coordination
diverse
abnormal
intracellular
events,
which
an
urgent
problem
and
great
challenge
for
its
application
in
AD
treatment.
Herein,
triphenylphosphonium-modified
quercetin-derived
smart
nanomedicine
(TQCN)
developed
multipronged
anti-ferroptosis
therapy
AD.
Taking
advantage
the
favorable
brain-targeting
mitochondria-locating
properties,
TQCN
can
efficiently
chelate
iron
through
phytopolyphenol-mediated
spontaneous
self-assemble
into
metal-phenolic
nanocomplexes
situ,
exerting
escalating
exogenous
offensive
effects
to
attenuate
overload
induced
free
radical
burst.
Meanwhile,
Nrf2
signaling-mediated
endogenous
defensive
system
reconstituted
restore
metabolism
homeostasis
represented
by
export
storage
enhance
cytoprotective
antioxidant
cascades
lipid
peroxidation
detoxification.
Benefiting
from
multifaceted
regulation
pathogenic
processes
triggering
ferroptosis,
treatment
ameliorate
various
neurodegenerative
manifestations
associated
with
brain
deposition
rescue
severe
cognitive
decline
mice.
This
work
displays
promise
situ
self-assembled
phytopolyphenol-coordinated
intelligent
nanotherapeutics
as
advanced
candidates
against
ferroptosis-driven
progression.
Life,
Год журнала:
2022,
Номер
12(4), С. 591 - 591
Опубликована: Апрель 15, 2022
Quercetin
is
one
of
the
most
common,
naturally
occurring
flavonoids,
structurally
classified
to
flavonol
subfamily.
This
compound,
found
in
many
edible
and
medicinal
plants
either
as
a
free
or
glycosidated
form,
has
been
scientifically
exploited
for
years,
could
hardly
expect
it
be
hero
some
additional
story.
Commonly
recognized
an
anti-inflammatory
agent,
quercetin
not
only
limits
capillary
vessel
permeability
by
inhibiting
hyaluronidase
but
also
blocks
cyclooxygenases
lipoxygenases.
As
typical
flavonoid,
known
its
antioxidant
effect,
which
was
confirmed
vitro
vivo
studies.
Throughout
numerous
other
activities
were
reported
quercetin,
including
antidiabetic,
anti-proliferative,
anti-viral.
Of
note,
recent
data
have
revealed
potential
role
therapeutic
agent
several
central
nervous
system
disorders.
review
provides
overview
available
experimental
on
complexes
with
respect
diseases,
main
focus
aspects
that
discussed
previously,
such
anti-anxiolytic
effects,
anti-Huntington’s
disease
activity,
brain
cancer.
Moreover,
quercetin’s
protective
these
diseases
discussed,
especially
anti-neuroinflammatory
agent.
Bearing
mind
poor
bioavailability
this
possible
options
would
enhance
delivery
site
action
are
presented.
