Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Янв. 10, 2022
Mitochondria,
as
one
of
the
most
critical
subcellular
organelles
cancer
cells,
are
very
vulnerable
and
often
on
verge
oxidative
stress.
The
classic
chemodynamic
therapy
(CDT)
directly
employs
endogenous
chemical
energy
to
trigger
reactive
oxygen
species
(ROS)
burst
destroy
tumor
cells.
However,
effectiveness
CDT
is
restricted
by
limited
diffusion
distance
short
half-life
ROS.
From
this
perspective,
treatment
method
(mitochondria-targeting
nanodrugs,
M-CDT
nanodrugs)
that
can
generate
high
levels
ROS
at
mitochondrial
site
extremely
efficient
promising
for
treatment.
Currently,
many
emerging
nanodrugs
have
been
demonstrated
excellent
spatial
specificity
anti-cancer
efficacy.
In
minireview,
we
review
various
proof-of-concept
researches
based
different
designs
overcome
limits
efficacy
CDT,
mainly
divided
into
four
strategies:
supplying
H
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23889 - 23902
Опубликована: Ноя. 25, 2023
Development
of
a
nanoscale
drug
delivery
system
that
can
simultaneously
exert
efficient
tumor
therapeutic
efficacy
while
creating
the
desired
antitumor
immune
responses
is
still
challenging.
Herein,
we
report
use
manganese
dioxide
(MnO2)-entrapping
dendrimer
nanocarrier
to
codeliver
glucose
oxidase
(GOx)
and
cyclic
GMP-AMP
(cGAMP),
an
agonist
stimulator
interferon
genes
(STING)
for
improved
chemodynamic/starvation/immune
therapy.
Methoxy
poly(ethylene
glycol)
(mPEG)-
phenylboronic
acid
(PBA)-modified
generation
5
(G5)
poly(amidoamine)
dendrimers
were
first
synthesized
then
entrapped
with
MnO2
nanoparticles
(NPs)
generate
hybrid
MnO2@G5-mPEG–PBA
(MGPP)
NPs.
The
created
MGPP
NPs
core
size
2.8
nm
display
glutathione
depletion
ability,
favorable
Mn2+
release
profile
under
microenvironment
mimetic
condition
enable
Fenton-like
reaction
T1-weighted
magnetic
resonance
(MR)
imaging.
We
show
MGPP-mediated
GOx
facilitates
enhanced
chemodynamic/starvation
therapy
cancer
cells
in
vitro,
further
codelivery
cGAMP
effectively
trigger
immunogenic
cell
death
(ICD)
strongly
promote
maturation
dendritic
cells.
In
bilateral
mouse
colorectal
model,
nanosystem
elicits
potent
performance
strong
abscopal
effect,
greatly
improving
overall
survival
rate.
Importantly,
dendrimer-mediated
not
only
allows
coordination
respective
chemodynamic/starvation-triggered
ICD
augmented
STING
activation
boost
systemic
responses,
but
also
enables
MR
imaging,
potentially
serving
as
promising
nanoplatform
responses.
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101292 - 101292
Опубликована: Апрель 6, 2024
The
prevalence
of
multidrug-resistant
(MDR)
bacterial
infections
has
emerged
as
a
serious
threat
to
clinical
treatment
and
global
human
health,
become
one
the
most
important
challenges
in
therapy.
Hence,
there
is
an
urgent
need
develop
safe,
effective,
new
antibacterial
strategies
based
on
multifunctional
nanomaterials
for
accurate
detection
MDR
infections.
Chemodynamic
therapy
(CDT)
emerging
therapeutic
strategy
that
uses
Fenton/Fenton-like
metal-based
nanocatalysts
convert
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(OH)
destroy
Despite
enormous
potential
CDT,
single
CDT
limitations
such
low
catalytic
efficacy
insufficient
production
H2O2.
In
this
regard,
can
be
combined
with
other
strategies,
photothermal
(PTT),
which
effectively
enhanced
by
PTT
heating
effect.
Thus,
rational
combination
nanoplatform
been
demonstrated
highly
efficient
achieving
better
This
review
summarizes
discusses
latest
advances
photothermal-enhanced
(PT/CDT)
infection
theranostics
well
advantages,
challenges,
future
research
directions
applications,
will
inspire
development
PT/CDT
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(5), С. 2643 - 2692
Опубликована: Янв. 1, 2024
This
review
discusses
the
structures
and
engineering
strategies
of
nanocatalysts,
highlighting
their
underlying
mechanisms
applications
in
cancer
immunotherapy.
Abstract
Metals
are
an
emerging
topic
in
cancer
immunotherapy
that
have
shown
great
potential
modulating
immunity
cycle
and
promoting
antitumor
by
activating
the
intrinsic
immunostimulatory
mechanisms
which
been
identified
recent
years.
The
main
challenge
of
metal‐assisted
lies
fact
free
metals
as
ion
forms
easily
cleared
during
circulation,
even
cause
systemic
metal
toxicity
due
to
off‐target
effects.
With
rapid
development
nanomedicine,
metal‐based
smart
nanosystems
(MSNs)
with
unique
controllable
structure
become
one
most
promising
delivery
carriers
solve
issue,
owing
their
various
endogenous/external
stimuli‐responsiveness
release
ions
for
metalloimmunotherapy.
In
this
review,
state‐of‐the‐art
research
progress
metal‐related
is
comprehensively
summarized.
First,
mainstream
MSNs‐assisted
will
be
delineated.
immunological
effects
certain
categorization
MSNs
different
characters
compositions
then
provided,
followed
representative
exemplar
applications
treatment,
synergistic
combination
immunotherapy.
Finally,
we
conclude
review
a
summary
remaining
challenges
associated
provide
authors'
perspective
on
further
advances.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(11), С. 13543 - 13562
Опубликована: Март 7, 2024
We
use
low-molecular-weight
branched
polyethylenimine
(PEI)
to
produce
cytocompatible
reduced
graphene
oxide
quantum
dots
(rGOQD)
as
a
photothermal
agent
and
covalently
bind
it
with
the
photosensitizer
IR-820.
The
rGOQD/IR820
shows
high
conversion
efficiency
produces
reactive
oxygen
species
(ROS)
after
irradiation
near-infrared
(NIR)
light
for
photothermal/photodynamic
therapy
(PTT/PDT).
To
improve
suspension
stability,
was
PEGylated
by
anchoring
DSPE
hydrophobic
tails
in
DSPE-PEG-Mal,
leaving
maleimide
(Mal)
end
group
covalent
binding
manganese
dioxide/bovine
serum
albumin
(MnO2/BSA)
targeting
ligand
cell-penetrating
peptide
(CPP)
synthesize
rGOQD/IR820/MnO2/CPP.
As
MnO2
can
react
intracellular
hydrogen
peroxide
alleviating
hypoxia
condition
acidic
tumor
microenvironment,
efficacy
of
PDT
could
be
enhanced
generating
more
cytotoxic
ROS
NIR
light.
Furthermore,
quercetin
(Q)
loaded
rGOQD
through
π–π
interaction,
which
released
endosomes
act
an
inhibitor
heat
shock
protein
70
(HSP70).
This
sensitizes
cells
thermal
stress
increases
mild-temperature
PTT
irradiation.
By
simultaneously
incorporating
HSP70
situ
(MnO2),
rGOQD/IR820/MnO2/Q/CPP
overcome
limitation
PTT/PDT
enhance
targeted
phototherapy
vitro.
From
vivo
study
orthotopic
brain
model,
administered
tail
vein
injection
cross
blood–brain
barrier
accumulate
intracranial
tumor,
laser
shrink
prolong
survival
times
animals
enhancing
treat
glioblastoma.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Янв. 21, 2022
Abstract
Background
Chemodynamic
therapy
is
a
promising
cancer
treatment
with
specific
therapeutic
effect
at
tumor
sites,
as
toxic
hydroxyl
radical
(·OH)
could
only
be
generated
by
Fenton
or
Fenton-like
reaction
in
the
microenvironment
(TME)
low
pH
and
high
level
of
endogenous
hydrogen
peroxide.
However,
concentration
catalytic
metal
ions,
excessive
glutathione
(GSH)
aggressive
hypoxia
site
seriously
restrict
curative
outcomes
conventional
chemodynamic
therapy.
Results
In
this
study,
polyethylene
glycol-phenylboronic
acid
(PEG-PBA)-modified
generation
5
(G5)
poly(amidoamine)
(PAMAM)
dendrimers
were
synthesized
targeted
nanocarrier
to
chelate
Cu(II)
then
encapsulate
hypoxia-sensitive
drug
tirapazamine
(TPZ)
formation
hydrophobic
Cu(II)/TPZ
complex
for
hypoxia-enhanced
chemo/chemodynamic
The
formed
G5.NHAc-PEG-PBA@Cu(II)/TPZ
(GPPCT)
nanoplatform
has
good
stability
hemocompatibility,
release
ions
TPZ
quickly
weakly
acidic
sites
via
pH-sensitive
dissociation
Cu(II)/TPZ.
vitro
experiments
showed
that
GPPCT
nanoplatforms
can
efficiently
target
murine
breast
cells
(4T1)
overexpressing
sialic
residues,
show
significantly
enhanced
inhibitory
on
hypoxic
activation
TPZ.
GSH
tumors
depleted
reduction
Cu(I),
abundant
·OH
would
vivo
demonstrated
specifically
accumulate
tumors,
effectively
inhibit
growth
metastasis
combination
CDT
chemotherapy,
metabolized
no
systemic
toxicity.
Conclusions
may
represent
an
effective
model
synergistic
inhibition
different
types
Graphical
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Авг. 5, 2023
Abstract
Chemodynamic
therapy
(CDT)
uses
the
Fenton
or
Fenton-like
reaction
to
yield
toxic
‧OH
following
H
2
O
→
for
tumoral
therapy.
Unfortunately,
is
often
taken
from
limited
endogenous
supply
of
in
cancer
cells.
A
water
oxidation
CoFe
Prussian
blue
(CFPB)
nanoframes
presented
provide
sustained,
external
energy-free
self-supply
process
CDT
and/or
photothermal
(PTT).
Unexpectedly,
as-prepared
CFPB
nanocubes
with
no
near-infrared
(NIR)
absorption
transformed
into
NIR
due
increased
Fe
3+
-N
≡
C-Fe
2+
composition
through
proposed
proton-induced
metal
replacement
reactions.
Surprisingly,
both
and
,
2,
O,
nanoframe
outperforming
production
‧OH.
Simulation
analysis
indicates
separated
active
sites
catalyzation
oxidation,
oxygen
reduction,
reactions
CFPB.
The
liposome-covered
prepared
controllable
water-driven
male
mice
treatments.
