NADPH Oxidases‐Inspired Reactive Oxygen Biocatalysts with Electron‐Rich Pt Sites to Potently Amplify Immune Checkpoint Blockade Therapy DOI Open Access

Chuyi Han,

Sutong Xiao, Zhenyu Xing

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Clinical immune checkpoint blockade (ICB)‐based immunotherapy of malignant tumors only elicits durable responses in a minority patients, primarily due to the highly immunosuppressive tumor microenvironment. Although inducing immunogenic cell death (ICD) through reactive oxygen biocatalyst represents an attractive therapeutic strategy amplify ICB, currently reported biocatalysts encounter insurmountable challenges achieving high ROS‐generating activity induce potent ICD. Here, inspired by natural catalytic characteristics NADPH oxidases, design efficient, robust, and electron‐rich Pt‐based redox centers on non‐stoichiometric W 18 O 49 substrates (Pt─WO x ) serve as bioinspired potently activate ICD, which eventually enhance cancer amplifies ICB‐based is reported. These studies demonstrate that Pt─WO exhibits rapid electron transfer capability can promote formation low oxophilic Pt for superior biocatalysis, enables ‐based inducers trigger endoplasmic reticulum stress directly stimulate amplifying anti‐PD‐L1‐based ICB therapy. This provides straightforward engineer also opens up new avenue create efficient ICD primary/metastatic treatments.

Язык: Английский

Osteosarcoma-Targeting PtIV Prodrug Amphiphile for Enhanced Chemo-Immunotherapy via Ca2+ trapping DOI
Jianqin Yan, Dengshuai Wei,

Zijian Zhao

и другие.

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

19
Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy DOI
Qiao Yu,

Shumin Sun,

Nailin Yang

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Язык: Английский

Процитировано

3
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

и другие.

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

Процитировано

3
Ternary Bi2WO6/TiO2–Pt Heterojunction Sonosensitizers for Boosting Sonodynamic Therapy DOI

Shengwu Wen,

Weiyun Zhang,

Jinlong Yang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(34), С. 23672 - 23683

Опубликована: Авг. 13, 2024

Engineering Z-scheme heterojunctions represents a promising strategy for optimizing the separation and migration of charge carriers in semiconductor sonosensitizers enhanced reactive oxygen species (ROS) generation. Nevertheless, establishing continuous directional pathway ultrasonic-induced flow remains significant challenge. In this study, we present ternary Bi

Язык: Английский

Процитировано

10
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101782 - 101782

Опубликована: Апрель 19, 2025

Язык: Английский

Процитировано

1
Current roles of metals in arming sonodynamic cancer therapy DOI

Zhuoli Chen,

Xianbo Wu, Jinzhe Liang

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 521, С. 216169 - 216169

Опубликована: Авг. 24, 2024

Язык: Английский

Процитировано

8
A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis DOI Creative Commons
Junyue Xing, Xiaohan Ma,

Yanan Yu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

Abstract Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated strong correlation between DOX‐induced cardiotoxicity and activation oxidative stress pathways. This work introduces novel antioxidant therapeutic approach, utilizing libraries tannic acid N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal nanozyme (AuRu) identified that possess remarkable characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal surface interactions prepared nanozymes simulate hydrogen peroxide decomposition process, showing these readily undergo OH⁻ adsorption O₂ desorption. To enhance targeting, atrial natriuretic peptide conjugated AuRu nanozyme. These cardiac‐targeted nanozymes, their anchoring capability, effectively cardiomyocyte ferroptosis PANoptosis without compromising tumor treatment efficacy. Thus, approach demonstrates significant reductions in chemotherapy‐induced cell death improvements function, accompanied by exceptional vivo biocompatibility stability. study presents promising avenue preventing offering potential clinical benefits cancer patients.

Язык: Английский

Процитировано

8
Novel Spatially Asymmetric Copper Bismuthate‐Mediated Augmentation of Energy Conversion to Realize “Three‐Step” Tumor Suppression DOI Creative Commons
Jiarui Wang,

Haoqin Zheng,

Guangyao Hu

и другие.

Advanced Science, Год журнала: 2024, Номер 11(25)

Опубликована: Апрель 23, 2024

The generally undesirable bandgap and electron-hole complexation of inorganic sonosensitizers limit the efficiency reactive oxygen species (ROS) generation, affecting effectiveness sonodynamic therapy (SDT). Comparatively, novel polyvinylpyrrolidone-modified copper bismuthate (PCBO) are manufactured for a "three-step" SDT promotion. In brief, first, strong hybridization between Bi 6s O 2p orbitals in PCBO narrows (1.83 eV), facilitating rapid transfer charge carriers. Additionally, nonequivalent [CuO

Язык: Английский

Процитировано

6
Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications DOI
Bin Zhang, Jiawei Zhu, Jinsong Ren

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(41)

Опубликована: Авг. 16, 2024

Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.

Язык: Английский

Процитировано

6
Dual Enzyme-Driven Cascade Reactions Modulate Immunosuppressive Tumor Microenvironment for Catalytic Therapy and Immune Activation DOI
Hengke Liu, Shanshan Jiang, Meng Li

и другие.

ACS Nano, Год журнала: 2024, Номер 18(44), С. 30345 - 30359

Опубликована: Окт. 21, 2024

Lactate-enriched tumor microenvironment (TME) fosters an immunosuppressive milieu to hamper the functionality of tumor-associated macrophages (TAMs). However, tackling effects wrought by lactate accumulation is still a big challenge. Herein, we construct dual enzyme-driven cascade reaction platform (ILH) with TME modulation for photoacoustic (PA) imaging-guided catalytic therapy and immune activation. The ILH composed iridium (Ir) metallene nanozyme, oxidase (LOx), hyaluronic acid (HA). combination Ir nanozyme LOx can not only efficiently consume reverse into immunoreactive one promoting polarization TAMs from M2 M1 phenotype, thus enhancing antitumor defense, but also alleviate hypoxia as well induce strong oxidative stress, triggering immunogenic cell death (ICD) activating immunity. Furthermore, photothermal performance strengthen ability endow PA response. Based on changes in signals endogenous molecules, three-dimensional multispectral imaging was utilized track process vivo. This work provides nanoplatform activation regulating TME.

Язык: Английский

Процитировано

5