Frontiers in Chemistry,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 19, 2025
Infection
is
one
of
the
leading
causes
failure
in
titanium-based
implant
materials
during
clinical
surgeries,
often
resulting
delayed
or
non-union
bone
healing.
Furthermore,
overuse
antibiotics
can
lead
to
bacterial
resistance.
Therefore,
developing
a
novel
material
with
both
antimicrobial
and
osteogenic
properties
great
significance.
In
this
study,
chitosan
(CS),
polydopamine
(PDA),
peptides
(AMPs)
HHC36
were
applied
modify
surface
titanium,
successful
preparation
composite
Ti-PDA-CS/PDA@HHC36
(abbreviated
as
T-P-C/P@H).
CS
promotes
osteogenesis
cell
adhesion,
providing
an
ideal
microenvironment
for
repair.
PDA
enhances
material's
biocompatibility
corrosion
resistance,
offering
adhesion
sites,
while
components
exhibit
pH-responsive
characteristics.
The
effectively
prevents
infection,
protecting
repair
from
damage.
Overall,
synergistic
effects
these
T-P-C/P@H
not
only
confer
excellent
but
also
improve
biocompatibility,
new
strategy
applying
implants
settings.
Applied Surface Science Advances,
Год журнала:
2023,
Номер
18, С. 100532 - 100532
Опубликована: Дек. 1, 2023
Advances
in
implantable
technologies
results
from
the
rapid
improvements
research
fields
of
biomedical
engineering,
biomaterial
science,
and
chemistry.
No
doubt,
have
provided
greater
comfort
against
several
illnesses
diseases;
however,
pathogens
adherence
biofilm
formation
are
still
issues
that
need
to
be
taken
into
consideration
for
further
implant
modifications.
Pathogens
colonize
implants
a
surface-dependent
manner,
so
chances
pathogens'
adhesion
can
minimized
by
creating
anti-adhesive
antimicrobial
surfaces.
The
ongoing
is
focused
on
design
appropriate
multifunctional
coatings
with
broad
spectrum
high
biocompatibility.
Antimicrobial
peptides
conjugation
polymers,
nanoparticles,
other
biocompatible
agents
potentially
used
develop
coatings.
Antibiotics-based
ultimate
approach;
optimizing
controlled
release
antibiotics
will
breakthrough
this
decade.
Polymers
unveil
extraordinary
potential
increasing
biocompatibility
coatings,
offering
possibility
triggered
agents.
An
in-depth
review
effective
herein.
We
thoroughly
discuss
remarkable
their
compatibility
host,
including
seemingly
underexplored
stability
providing
an
overlook
different
methods
fabrication.
ever-growing
materials
field
use
review's
highlights
reduce
implant-associated
infections.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(11)
Опубликована: Янв. 9, 2023
Implant-associated
infection
and
inflammation
are
the
main
causes
of
implant
failure,
causing
irreversible
damage
significantly
increasing
clinical
risks
economic
losses.
In
this
study,
a
3D
multifunctional
architecture
is
constructed
that
consisted
hierarchical
TiO2
nanotubes
(NTs)
electrospun
polyvinylidene
fluoride
nanofiber
layers
on
surface
titanium
implant.
The
movement
bacteria
through
layer
facilitated
by
its
appropriate
pore
sizes
electrostatic
interactions
to
reach
NT
where
killed
positive
charge
traps.
contrast,
macrophages
tend
adhere
layer.
mechanical
between
piezoelectric
nanofibers
generate
self-stimulated
electric
field
regulated
an
anti-inflammatory
phenotype.
This
study
provides
new
method
for
materials
with
antibacterial,
piezoelectrically
anti-inflammatory,
osteointegration
properties
driven
electrical
stimulation.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(6), С. 8886 - 8900
Опубликована: Янв. 31, 2025
The
controllable
regulation
of
immune
and
osteogenic
processes
plays
a
critical
role
in
the
modification
biocompatible
materials
for
tissue
regeneration.
In
this
study,
titanium
dioxide-europium
coatings
(MAO/Eu)
were
prepared
on
surface
alloy
(Ti-6Al-4V)
via
one-step
process
combining
microarc
oxidation
(MAO)
situ
doping.
incorporation
Eu
significantly
improved
hydrophilic
mechanical
properties
TiO2
without
altering
their
morphology.
presence
effectively
stimulated
calcium
influx
macrophages
activated
β-catenin
through
wnt/β-catenin
signaling
pathway.
Consequently,
macrophage
M2
polarization
was
accelerated
overexpression
prostaglandin
E2
(PGE2).
Additionally,
Ca2+
promoted
differentiation
MC3T3-E1
cells
synergistic
upregulation
transcription
factors
(e.g.,
AP-1,
BMP-2).
vivo
studies
demonstrated
that
MAO/Eu
enhanced
osseointegration
compared
with
group.
Therefore,
shows
promising
potential
as
an
ideal
coating
implants
offers
effective
immunomodulatory
strategies
improves
bone
integration.
Frontiers in Chemistry,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 19, 2025
Infection
is
one
of
the
leading
causes
failure
in
titanium-based
implant
materials
during
clinical
surgeries,
often
resulting
delayed
or
non-union
bone
healing.
Furthermore,
overuse
antibiotics
can
lead
to
bacterial
resistance.
Therefore,
developing
a
novel
material
with
both
antimicrobial
and
osteogenic
properties
great
significance.
In
this
study,
chitosan
(CS),
polydopamine
(PDA),
peptides
(AMPs)
HHC36
were
applied
modify
surface
titanium,
successful
preparation
composite
Ti-PDA-CS/PDA@HHC36
(abbreviated
as
T-P-C/P@H).
CS
promotes
osteogenesis
cell
adhesion,
providing
an
ideal
microenvironment
for
repair.
PDA
enhances
material's
biocompatibility
corrosion
resistance,
offering
adhesion
sites,
while
components
exhibit
pH-responsive
characteristics.
The
effectively
prevents
infection,
protecting
repair
from
damage.
Overall,
synergistic
effects
these
T-P-C/P@H
not
only
confer
excellent
but
also
improve
biocompatibility,
new
strategy
applying
implants
settings.
