Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(11)
Published: Jan. 9, 2023
Implant-associated
infection
and
inflammation
are
the
main
causes
of
implant
failure,
causing
irreversible
damage
significantly
increasing
clinical
risks
economic
losses.
In
this
study,
a
3D
multifunctional
architecture
is
constructed
that
consisted
hierarchical
TiO2
nanotubes
(NTs)
electrospun
polyvinylidene
fluoride
nanofiber
layers
on
surface
titanium
implant.
The
movement
bacteria
through
layer
facilitated
by
its
appropriate
pore
sizes
electrostatic
interactions
to
reach
NT
where
killed
positive
charge
traps.
contrast,
macrophages
tend
adhere
layer.
mechanical
between
piezoelectric
nanofibers
generate
self-stimulated
electric
field
regulated
an
anti-inflammatory
phenotype.
This
study
provides
new
method
for
materials
with
antibacterial,
piezoelectrically
anti-inflammatory,
osteointegration
properties
driven
electrical
stimulation.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: July 16, 2022
Combating
bacterial
infections
is
one
of
the
most
important
applications
nanomedicine.
In
past
two
decades,
significant
efforts
have
been
committed
to
tune
physicochemical
properties
nanomaterials
for
development
various
novel
nanoantibiotics.
Among
which,
metal
nanoclusters
(NCs)
with
well-defined
ultrasmall
size
and
adjustable
surface
chemistry
are
emerging
as
next-generation
high
performance
Metal
NCs
can
penetrate
cell
envelope
more
easily
than
conventional
due
their
size.
Meanwhile,
abundant
active
sites
help
catalyze
intracellular
biochemical
processes,
resulting
in
enhanced
antibacterial
properties.
this
review,
we
discuss
recent
developments
a
new
generation
antimicrobial
agents.
Based
on
brief
introduction
characteristics
NCs,
highlight
general
working
mechanisms
by
which
combating
infections.
We
also
emphasize
central
roles
core
size,
element
composition,
oxidation
state,
efficacy.
Finally,
present
perspective
remaining
challenges
future
therapeutics.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(44), P. 51713 - 51726
Published: Oct. 26, 2023
Biodegradable
gelatin
(G)
food
packaging
films
are
in
increasing
demand
as
the
substitution
of
petroleum-based
preservative
materials.
However,
G
universally
suffer
from
weak
hydrophobicity
practical
applications.
Constructing
a
hydrophobic
micro/nanocoating
with
low
surface
energy
is
an
effective
countermeasure.
poor
compatibility
hydrophilic
substrate
often
leads
to
interfacial
adhesion
and
durability
coating.
To
overcome
this
obstacle,
we
used
(3-aminopropyl)
triethoxysilane
(APS)
bridging
agent
prepare
highly
hydrophobic,
versatile
nanocomposite
film.
Specifically,
tannic
acid
(TA)-modified
nanohydroxyapatite
(n-HA)
particles
(THA)
were
introduced
matrix
(G-THA)
improve
mechanical
properties.
Micro/nanostructure
composed
nanozinc
oxide
(Nano-ZnO)/APS/stearic
(SA)
(NAS)
was
constructed
on
G-THA
film
(G-THA/NAS)
through
one-step
spray
treatment.
Consequently,
as-prepared
G-THA/NAS
presented
excellent
mechanics
(tensile
strength:
7.6
MPa,
elongation
at
break:
292.7%),
water
resistance
ability
(water
contact
angle:
150.4°),
high
UV-shielding
(0%
transmittance
200
nm),
degradability
(100%
degradation
rate
after
buried
natural
soil
for
15
days),
antioxidant
(78.8%
2,2-diphenyl-1-picrylhydrazyl
radical
scavenging
activity),
antimicrobial
(inhibition
zone
against
Escherichia
coli:
15.0
mm
Staphylococcus
aureus:
16.5
mm)
It
should
be
emphasized
that
function
APS
significantly
improves
NAS
coating
more
than
95%
remaining
area
cross-cut
test.
Meanwhile,
could
maintain
stable
long-lasting
surfaces
UV
radiation,
temperature,
abrasion.
Based
these
multifunctional
properties,
successfully
applied
liquid
material.
sum
up,
provide
feasible
method
high-performance
green
films.
Applied Surface Science Advances,
Journal Year:
2023,
Volume and Issue:
18, P. 100532 - 100532
Published: Dec. 1, 2023
Advances
in
implantable
technologies
results
from
the
rapid
improvements
research
fields
of
biomedical
engineering,
biomaterial
science,
and
chemistry.
No
doubt,
have
provided
greater
comfort
against
several
illnesses
diseases;
however,
pathogens
adherence
biofilm
formation
are
still
issues
that
need
to
be
taken
into
consideration
for
further
implant
modifications.
Pathogens
colonize
implants
a
surface-dependent
manner,
so
chances
pathogens'
adhesion
can
minimized
by
creating
anti-adhesive
antimicrobial
surfaces.
The
ongoing
is
focused
on
design
appropriate
multifunctional
coatings
with
broad
spectrum
high
biocompatibility.
Antimicrobial
peptides
conjugation
polymers,
nanoparticles,
other
biocompatible
agents
potentially
used
develop
coatings.
Antibiotics-based
ultimate
approach;
optimizing
controlled
release
antibiotics
will
breakthrough
this
decade.
Polymers
unveil
extraordinary
potential
increasing
biocompatibility
coatings,
offering
possibility
triggered
agents.
An
in-depth
review
effective
herein.
We
thoroughly
discuss
remarkable
their
compatibility
host,
including
seemingly
underexplored
stability
providing
an
overlook
different
methods
fabrication.
ever-growing
materials
field
use
review's
highlights
reduce
implant-associated
infections.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(11)
Published: Jan. 9, 2023
Implant-associated
infection
and
inflammation
are
the
main
causes
of
implant
failure,
causing
irreversible
damage
significantly
increasing
clinical
risks
economic
losses.
In
this
study,
a
3D
multifunctional
architecture
is
constructed
that
consisted
hierarchical
TiO2
nanotubes
(NTs)
electrospun
polyvinylidene
fluoride
nanofiber
layers
on
surface
titanium
implant.
The
movement
bacteria
through
layer
facilitated
by
its
appropriate
pore
sizes
electrostatic
interactions
to
reach
NT
where
killed
positive
charge
traps.
contrast,
macrophages
tend
adhere
layer.
mechanical
between
piezoelectric
nanofibers
generate
self-stimulated
electric
field
regulated
an
anti-inflammatory
phenotype.
This
study
provides
new
method
for
materials
with
antibacterial,
piezoelectrically
anti-inflammatory,
osteointegration
properties
driven
electrical
stimulation.
