Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 25, 2023

Triple-negative breast cancer (TNBC) is characterized by a high degree of malignancy, early metastasis, limited treatment, and poor prognosis. Immunotherapy, as new most promising treatment for cancer, has efficacy in TNBC because the immunosuppressive tumor microenvironment (TME). Inducing pyroptosis activating cyclic guanosine monophosphate-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity have become an emerging strategy enhancing immunotherapy. In this study, albumin nanospheres were constructed with photosensitizer-IR780 encapsulated core cGAS–STING agonists/H 2 S producer-ZnS loaded on shell (named IR780-ZnS@HSA). vitro , IR780-ZnS@HSA produced photothermal therapy (PTT) photodynamic (PDT) effects. addition, it stimulated immunogenic cell death (ICD) activated cells via caspase-3–GSDME pathway. also The two pathways synergistically boost immune response. vivo + laser significantly inhibited growth 4T1 tumor-bearing mice triggered response, improving anti-APD-L1 antibody (aPD-L1). conclusion, IR780-ZnS@HSA, novel inducer pyroptosis, can inhibit improve aPD-L1.

Язык: Английский

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Recent advances on nanostructured biomaterials in osteosarcoma treatment

Coordination Chemistry Reviews, Год журнала: 2023, Номер 493, С. 215315 - 215315

Опубликована: Июнь 24, 2023

Язык: Английский

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Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4139 - 4139

Опубликована: Апрель 9, 2024

Bone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in Conventional treatment methods comprise extensive surgical resection, radiotherapy, chemotherapy. Consequently, management bone tumors regeneration poses significant clinical challenges. Photothermal tumor therapy attracted considerable attention owing to its minimal invasiveness high selectivity. However, key challenges have limited widespread use. Enhancing specificity photosensitizers through targeting or localized activation holds potential for better outcomes with fewer adverse effects. Combinations chemotherapies immunotherapies also present avenues improvement. In this review, we provide an overview recent strategies aimed at overcoming limitations photothermal (PTT), along current research directions context including (1) target strategies, (2) combined multiple therapies (immunotherapies, chemotherapies, chemodynamic therapies, magnetic, photodynamic therapies), (3) bifunctional scaffolds regeneration. We delve into pros cons these combination explore focal points. Lastly, address prospects therapy.

Язык: Английский

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Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(1)

Опубликована: Янв. 1, 2024

Abstract Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as transformative force in cancer treatment, particularly through nano‐enabled photodynamic therapy (NE‐PDT), which leverages precise and targeted interventions. NE‐PDT capitalizes on photosensitizers activated by light generate reactive oxygen species (ROS) initiate apoptotic pathways cells. Nanoparticle enhancements optimize this process, improving drug delivery, selectivity, ROS production within tumors. This review dissects NE‐PDT's mechanistic framework, showcasing its potential harness apoptosis potent tool therapy. Furthermore, the explores synergy between complementary treatments like chemotherapy, immunotherapy, therapies, highlighting amplify responses, enhance immune recognition of cells, inhibit resistance mechanisms. Preclinical clinical advancements demonstrate efficacy across various types. Challenges translating into practice are also addressed, emphasizing need for optimizing nanoparticle design, refining dosimetry, ensuring long‐term safety. Ultimately, represents promising approach therapy, utilizing intricate mechanisms address therapeutic hurdles. The underscores importance understanding interplay nanoparticles, generation, pathways, contributing deeper comprehension biology novel strategies. As interdisciplinary collaborations continue thrive, offers hope effective interventions, where manipulation becomes central conquering cancer. article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease

Язык: Английский

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Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 12, 2024

Abstract Background Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With application new chemotherapy regimens, finding and effective anti-OS drugs to coordinate program implementation urgent for patients OS. Oridonin had been proved mediate anti-tumor effect on OS cells, but its mechanism has not fully elucidated. Methods The effects oridonin viability, clonal formation migration 143B U2OS cells were detected by CCK-8, colony assays wound-healing test. Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis was used explore Western blot (WB), real-time quantitative PCR (qRT-PCR) detect expression levels apoptosis ferroptosis-relative proteins genes. Annexin V-FITC detection kit flow cytometry examination level apoptosis. Iron assay evaluate relative Fe 2+ content. mitochondrial membrane potential lipid peroxidation production determined ROS kit. Results could effectively inhibit survival, metastasis cells. KEGG results indicated that associated with malignant phenotypic signaling pathways proliferation, migration, drug resistance capable inhibiting expressions BAX, cl-caspase3, SLC7A11, GPX4 FTH1 mRNA, while promoting Bcl-2 ACSL4 Additionally, we found promote accumulation reactive oxygen species (ROS) as well reduce potential, these be significantly reversed ferroptosis inhibitor ferrostatin-1 (Fer-1). Conclusion can trigger collaboratively making it a promising agent therapy.

Язык: Английский

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Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 69 - 69

Опубликована: Янв. 21, 2025

Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.

Язык: Английский

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Engineered anti-cancer nanomedicine for synergistic ferroptosis-immunotherapy

Chemical Engineering Journal, Год журнала: 2022, Номер 455, С. 140688 - 140688

Опубликована: Дек. 1, 2022

Язык: Английский

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Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Drug Discovery Today, Год журнала: 2022, Номер 28(3), С. 103469 - 103469

Опубликована: Дек. 15, 2022

Язык: Английский

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Enhanced ferroptosis therapy with a “nano-destructor” by disrupting intracellular redox and iron homeostasis

Nano Today, Год журнала: 2023, Номер 51, С. 101896 - 101896

Опубликована: Июнь 7, 2023

Язык: Английский

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Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Cancers, Год журнала: 2023, Номер 15(20), С. 5043 - 5043

Опубликована: Окт. 19, 2023

Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest it promising of tumor cell death. regulated by iron metabolism, lipid intracellular reducing substances, which the mechanism basis its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) 1O2 through type I II photochemical reactions, subsequently induces ferroptosis Fenton reaction peroxidation membrane lipids. kills cells generating excessive cytotoxic ROS. Due to limited laser depth photosensitizer enrichment, systemic treatment effect not good. Combining can compensate for these shortcomings. Nanoparticles constructed photosensitizers agonists are widely used field therapy, their targeting biological safety be improved modification. These nanoparticles only directly kill but also further exert synergistic activating antitumor immunity, improving hypoxia microenvironment, inhibiting angiogenesis. Ferroptosis-agonist-induced chemotherapy PDT-induced ablation have good clinical application prospects. In this review, we summarize current research progress on how promote each other.

Язык: Английский

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