CRISPR/Cas9-based application for cancer therapy: Challenges and solutions for non-viral delivery

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 727 - 749

Опубликована: Авг. 22, 2023

Язык: Английский

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Iron-Based Nanovehicle Delivering Fin56 for Hyperthermia-Boosted Ferroptosis Therapy Against Osteosarcoma

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 91 - 107

Опубликована: Янв. 1, 2024

Background: Although systemic chemotherapy is a standard approach for osteosarcoma (OS) treatment, its efficacy limited by the inherent or acquired resistance to apoptosis of tumor cells. Ferroptosis considered as an effective strategy capable stimulating alternative pathways cancer cell demise. The purpose this study develop novel boosting ferroptotic cascade synergistic therapy. Methods and Results: A nanovehicle composed arginine-glycine-aspartate (RGD) modified mesoporous silica-coated iron oxide loading Fin56 was rationally prepared (FSR-Fin56). With RGD-mediated targeting affinity, FSR-Fin56 could achieve selective accumulation accurate delivery cargos into Upon exposure NIR light, generate localized hyperthermia disintegrate liberate therapeutic payload. released triggered degradation GPX4, while Fe 3+ depleted intracellular GSH pool, producing 2+ Fenton agent. local rise in temperature, conjunction with -mediated reaction, led rapid significant ROS, culminating LPOs death. outstanding safety were validated both vitro vivo. Conclusion: Fin56-loaded FSR effectively disturb redox balance Coupled laser irradiation, cooperative CDT PTT achieved boosted ferroptosis-inducing Taken together, offers compelling particularly ferroptosis-sensitive tumors like osteosarcoma. Keywords: chemodynamic therapy, photothermal Fin56, ferroptosis

Язык: Английский

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Exploring the frontiers: the potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101276 - 101276

Опубликована: Сен. 30, 2024

Язык: Английский

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Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Nanomaterials, Год журнала: 2024, Номер 14(2), С. 186 - 186

Опубликована: Янв. 13, 2024

Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer bone cancer, such as osteosarcoma and Ewing tumors, which occur frequently infants. This study shows an active interest the use graphene oxide its derivatives therapy against cancer. We present systematic review analyzing current state art related to GO treating osteosarcoma, through evaluating existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications were reviewed, has revealed that there excellent trend toward nanomaterials, based their thermal anti-cancer activities, treatment various therapeutic approaches. However, research needed develop highly efficient localized therapies. It suggested, therefore, photodynamic therapy, photothermal nanocarriers should be considered non-invasive, specific, alternatives osteosarcoma. These options promising approaches enhance effectiveness while also seeking reduce side effects minimize damage surrounding healthy tissues. The bibliometric analysis photochemical treatments reduced from January 2004 December 2022 extracted 948 documents with search strategy, mainly papers, conference demonstrating high-impact field supported by need selective central countries leading are United States, Iran, Italy, Germany, China, South Korea, Australia, strong collaborations At same time, most-cited papers published journals impact factors 6.0 (2021), 290 citations. Additionally, most topic high factor journals, according performed, field.

Язык: Английский

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Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma

International Journal of Pharmaceutics, Год журнала: 2024, Номер 652, С. 123865 - 123865

Опубликована: Янв. 28, 2024

Язык: Английский

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