The Journal of Pathology,
Journal Year:
2024,
Volume and Issue:
262(4), P. 427 - 440
Published: Jan. 17, 2024
Radiotherapy
is
one
of
the
standard
therapeutic
regimens
for
medulloblastoma
(MB).
Tumor
cells
utilize
DNA
damage
repair
(DDR)
mechanisms
to
survive
and
develop
resistance
during
radiotherapy.
It
has
been
found
that
targeting
DDR
sensitizes
tumor
radiotherapy
in
several
types
cancer,
but
whether
how
pathways
are
involved
MB
response
remain
be
determined.
Single-cell
RNA
sequencing
was
carried
out
on
38
tissues,
followed
by
expression
enrichment
assays.
Fanconi
anemia
group
D2
gene
(FANCD2)
evaluated
samples
public
databases.
The
function
FANCD2
examined
using
cell
counting
assays
(CCK-8),
clone
formation,
lactate
dehydrogenase
activity,
mouse
orthotopic
models.
FANCD2-related
signaling
pathway
investigated
peroxidation,
a
malondialdehyde
assay,
reduced
glutathione
FerroOrange
assess
intracellular
iron
ions
(Fe
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(2), P. 186 - 186
Published: Jan. 13, 2024
Cancer
is
a
severe
disease
that,
in
2022,
caused
more
than
9.89
million
deaths
worldwide.
One
worrisome
type
of
cancer
bone
cancer,
such
as
osteosarcoma
and
Ewing
tumors,
which
occur
frequently
infants.
This
study
shows
an
active
interest
the
use
graphene
oxide
its
derivatives
therapy
against
cancer.
We
present
systematic
review
analyzing
current
state
art
related
to
GO
treating
osteosarcoma,
through
evaluating
existing
literature.
In
this
sense,
studies
focused
on
GO-based
nanomaterials
for
potential
applications
were
reviewed,
has
revealed
that
there
excellent
trend
toward
nanomaterials,
based
their
thermal
anti-cancer
activities,
treatment
various
therapeutic
approaches.
However,
research
needed
develop
highly
efficient
localized
therapies.
It
suggested,
therefore,
photodynamic
therapy,
photothermal
nanocarriers
should
be
considered
non-invasive,
specific,
alternatives
osteosarcoma.
These
options
promising
approaches
enhance
effectiveness
while
also
seeking
reduce
side
effects
minimize
damage
surrounding
healthy
tissues.
The
bibliometric
analysis
photochemical
treatments
reduced
from
January
2004
December
2022
extracted
948
documents
with
search
strategy,
mainly
papers,
conference
demonstrating
high-impact
field
supported
by
need
selective
central
countries
leading
are
United
States,
Iran,
Italy,
Germany,
China,
South
Korea,
Australia,
strong
collaborations
At
same
time,
most-cited
papers
published
journals
impact
factors
6.0
(2021),
290
citations.
Additionally,
most
topic
high
factor
journals,
according
performed,
field.
The Journal of Pathology,
Journal Year:
2024,
Volume and Issue:
262(4), P. 427 - 440
Published: Jan. 17, 2024
Radiotherapy
is
one
of
the
standard
therapeutic
regimens
for
medulloblastoma
(MB).
Tumor
cells
utilize
DNA
damage
repair
(DDR)
mechanisms
to
survive
and
develop
resistance
during
radiotherapy.
It
has
been
found
that
targeting
DDR
sensitizes
tumor
radiotherapy
in
several
types
cancer,
but
whether
how
pathways
are
involved
MB
response
remain
be
determined.
Single-cell
RNA
sequencing
was
carried
out
on
38
tissues,
followed
by
expression
enrichment
assays.
Fanconi
anemia
group
D2
gene
(FANCD2)
evaluated
samples
public
databases.
The
function
FANCD2
examined
using
cell
counting
assays
(CCK-8),
clone
formation,
lactate
dehydrogenase
activity,
mouse
orthotopic
models.
FANCD2-related
signaling
pathway
investigated
peroxidation,
a
malondialdehyde
assay,
reduced
glutathione
FerroOrange
assess
intracellular
iron
ions
(Fe
