Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 30, 2024
The
underlying
mechanism
of
vascular
endothelial
hyperpermeability
caused
by
decrease
junctions
occurring
in
atherosclerosis
remains
elusive.
Our
findings
identified
that
plasma
exosomes
from
patients
with
stable
coronary
artery
disease
(ExoSCAD)
contain
differentially
expressed
miRNAs
are
clustered
genes
related
to
cell
junctions,
prompting
us
investigate
the
role
ExoSCAD
regulating
and
elucidate
mechanisms.
Here,
we
show
markedly
impair
via
suppressing
VE-Cadherin
ZO-1
cells
vitro
vivo,
consequently
increases
permeability.
Critically,
exosomal
miR-140-3p
plays
a
crucial
ExoSCAD-induced
inhibition
ZO-1,
may
be
an
important
causative
factor
development
during
atherosclerosis.
Additionally,
miR-140–3p
level
coordinates
severity
SCAD.
Targeting
circulating
might
open
novel
options
for
treatment
Bioactive Materials,
Год журнала:
2024,
Номер
39, С. 521 - 543
Опубликована: Май 30, 2024
Spinal
cord
injury
(SCI)
often
results
in
irreversible
loss
of
sensory
and
motor
functions,
most
SCIs
are
incurable
with
current
medical
practice.
One
the
hardest
challenges
treating
SCI
is
development
a
dysfunctional
pathological
microenvironment,
which
mainly
comprises
excessive
inflammation,
deposition
inhibitory
molecules,
neurotrophic
factor
deprivation,
glial
scar
formation,
imbalance
vascular
function.
To
overcome
this
challenge,
implantation
functional
biomaterials
at
site
has
been
regarded
as
potential
treatment
for
modulating
microenvironment
to
support
axon
regeneration,
remyelination
site,
recovery
after
SCI.
This
review
summarizes
characteristics
recent
advances
well
technologies
used
modulate
inflammatory
regulate
reshape
revascularization
microenvironment.
Moreover,
technological
limitations,
challenges,
future
prospects
promote
efficient
repair
also
discussed.
will
aid
further
understanding
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1462 - 1462
Опубликована: Ноя. 28, 2024
Upregulation
of
reactive
oxygen
species
(ROS)
levels
is
a
principal
feature
observed
in
the
brains
neurodegenerative
diseases
such
as
Parkinson’s
disease
(PD)
and
Alzheimer’s
(AD).
In
these
diseases,
oxidative
stress
can
disrupt
blood–brain
barrier
(BBB).
This
disruption
allows
neurotoxic
plasma
components,
blood
cells,
pathogens
to
enter
brain,
leading
increased
ROS
production,
mitochondrial
dysfunction,
inflammation.
Collectively,
factors
result
protein
modification,
lipid
peroxidation,
DNA
damage,
and,
ultimately,
neural
cell
damage.
this
review
article,
we
present
mechanisms
by
which
damage
leads
BBB
breakdown
brain
diseases.
Additionally,
summarize
potential
therapeutic
approaches
aimed
at
reducing
that
contributes
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5863 - 5863
Опубликована: Май 28, 2024
Extracellular
vesicles
(EVs),
including
exosomes,
microvesicles,
and
other
lipid
derived
from
cells,
play
a
pivotal
role
in
intercellular
communication
by
transferring
information
between
cells.
EVs
secreted
progenitor
stem
cells
have
been
associated
with
the
therapeutic
effects
observed
cell-based
therapies,
they
also
contribute
to
tissue
regeneration
following
injury,
such
as
orthopaedic
surgery
cases.
This
review
explores
involvement
of
nerve
regeneration,
their
potential
drug
carriers,
significance
cell
research
cell-free
therapies.
It
underscores
importance
bioengineers
comprehending
manipulating
EV
activity
optimize
efficacy
engineering
regenerative
Journal of Cellular Physiology,
Год журнала:
2025,
Номер
240(1)
Опубликована: Янв. 1, 2025
Vascular
regeneration
plays
a
vital
role
in
tissue
repair
yet
is
drastically
impaired
those
with
spinal
cord
injury
(SCI).
Pericytes
are
of
great
significance
as
they
entwined
vessel-specific
endothelial
cells
and
actively
contribute
to
maintaining
the
cord's
vascular
network.
Within
neurovascular
unit
(NVU),
subtypes
pericytes
characterized
by
various
markers
such
PDGFR-β,
Desmin,
CD146,
NG-2
involved
SCI
repair.
Various
pericyte
signaling,
pericyte-derived
exosomes,
endothelial-pericyte
interplay
were
revealed
participate
or
fibrotic
scars.
Through
further
understanding
biology,
it
aimed
accurately
generate
develop
their
therapeutic
potential.
This
review
focuses
on
recent
advanced
research
development
potential
treatment
for
SCI.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 723 - 723
Опубликована: Янв. 16, 2025
Mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
have
emerged
as
a
promising
therapeutic
strategy
for
spinal
cord
injury
(SCI).
These
nanosized
possess
unique
properties
such
low
immunogenicity
and
the
ability
to
cross
biological
barriers,
making
them
ideal
carriers
delivering
bioactive
molecules
injured
tissues.
MSC-EVs
been
demonstrated
exert
multiple
beneficial
effects
in
SCI,
including
reducing
inflammation,
promoting
neuroprotection,
enhancing
axonal
regeneration.
Recent
studies
delved
into
molecular
mechanisms
underlying
MSC-EV-mediated
effects.
Exosomal
microRNAs
(miRNAs)
identified
key
regulators
of
various
cellular
processes
involved
SCI
pathogenesis
repair.
miRNAs
can
influence
oxidative
stress,
apoptosis
by
modulating
gene
expression.
This
review
summarized
current
state
MSC-EV-based
therapies
highlighting
potential
clinical
applications.
We
discussed
challenges
limitations
translating
these
practice,
inconsistent
EV
production,
complex
cargo
composition,
need
targeted
delivery
strategies.
Future
research
should
focus
on
optimizing
production
characterization,
identifying
miRNAs,
developing
innovative
systems
maximize
SCI.
Brain Research Bulletin,
Год журнала:
2025,
Номер
unknown, С. 111233 - 111233
Опубликована: Янв. 1, 2025
Spinal
cord
injury
(SCI)
represents
a
severe
disorder
of
the
nervous
system,
imposing
significant
physical,
psychological,
and
socioeconomic
burdens
on
affected
individuals
society.
We
investigated
implication
O-linked
β-N-acetylglucosamine
(O-GlcNAcylation)
in
regulating
pyroptosis
related
proteins
at
posttranslational
level.
PC12
cells
were
stimulated
with
lipopolysaccharide
(LPS).
The
O-GlcNAcylation
pathway
was
modified
by
manipulating
expression
O-GlcNAc
transferase
(OGT)
or
O-GlcNAcase
(OGA).
Pro-inflammatory
cytokine
levels
cell
assessed.
Co-immunoprecipitation
(Co-IP)
assays
employed
to
investigate
interaction
between
NLRP3
OGT.
For
vivo
studies,
an
established
SCI
rat
model
utilized.
Levels
pro-inflammatory
factors,
inflammasome
components,
associated
measured.
Both
OGT
significantly
elevated
cells.
Inhibition
led
marked
reduction
cytokines
suppression
pyroptosis.
Furthermore,
inhibition
resulted
downregulation
its
O-GlcNAcylation,
while
overexpression
produced
opposite
effect.
verified
endogenous
exogenous
interactions
Importantly,
knockout
mitigated
progression
animal
model,
suggesting
protective
role
SCI.
This
study
preliminarily
proved
that
mechanism
mediated
participates
action
Targeting
may
be
novel
therapy
method
