Nano Today, Год журнала: 2024, Номер 61, С. 102595 - 102595
Опубликована: Дек. 13, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 488, С. 150945 - 150945
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
9
Chemical Engineering Journal, Год журнала: 2024, Номер 486, С. 150125 - 150125
Опубликована: Март 3, 2024
Язык: Английский
Процитировано
5
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 29, 2025
A wearable artificial kidney (WAK) stands poised to offer dialysis treatment with maximal temporal and spatial flexibility for end-stage renal disease (ESRD) patients, while portability has not yet been achieved due difficulties in portable purification. The ion concentration polarization (ICP), one of the nanoelectrokinetic phenomenon, garnered substantial attention realm purification applications, owing its remarkable capacity charge separation. In this work, scalable ICP dialyzer 10,000-fold increase throughput, was applied peritoneal dialysate regeneration. First, mechanism underpinning corroborated based on micro-nanofluidics. Simultaneously, electrochemical reactions utilized complete decomposition uncharged toxin (urea), achieving approximately 99% clearance, phenomenon promoted removal positively charged (creatinine), 30% clearance. Second, 3-D developed a creation micro-nanofluidic environment inside. Throughput scalability demonstrated up 1 mL/min average toxins Ultimately, assist (PD) using bilateral nephrectomy rat model. We that regenerated successfully reduced vivo toxicity, ratio per cycle. believe integration into WAK holds tremendous potential substantially enhancing quality life individuals ESRD.
Язык: Английский
Процитировано
0
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 39, С. 101310 - 101310
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 21, 2024
Epidermal growth factor receptor (EGFR), which is referred to as ErbB1/HER1, the prototype of EGFR family tyrosine kinases also comprises ErbB2 (Neu, HER2), ErbB3 (HER3), and ErbB4 (HER4). EGFR, along with other ErbBs, expressed in kidney tubules physiologically involved nephrogenesis tissue repair, mainly following acute injury. However, its sustained activation linked several pathologies, including diabetic nephropathy, hypertensive glomerulonephritis, chronic disease, renal fibrosis. This review aims provide a summary recent findings regarding consequences key pathologies. We discuss potential interplay between reno-protective angiotensin-(1–7) (Ang-(1–7), heptapeptide member renin-angiotensin-aldosterone system that counter-regulates actions angiotensin II. Ang-(1–7)-mediated inhibition transactivation might represent mechanism action for renoprotection. Our suggests there significant body evidence supporting EGFR/ErbB, and/or administration Ang-(1–7), novel therapeutic strategies treatment Thus, inhibitors such Gefitinib Erlinotib have an acceptable safety profile been clinically used cancer chemotherapy since their FDA approval early 2000s, be considered repurposing
Язык: Английский
Процитировано
0
Egyptian Academic Journal of Biological Sciences. B, Zoology, Год журнала: 2024, Номер 16(2), С. 55 - 69
Опубликована: Авг. 24, 2024
Diabetic nephropathy (DN) is another name for diabetic kidney disease (DKD). This a prevalent issue among people with diabetes worldwide. health condition affecting the renal glomeruli and causes nephropathy. Hyperglycemia most important contributing factor to development of DN, where blood vessels in tissue may get damaged as result continuously elevated sugar levels, specifically endothelial cells glomeruli, which leads weak capillaries, affected glomerular filtration rate (GFR), onset albuminuria, ultimately damage. However, reasons this are unclear, making treatment hard costly. It correlated an increased danger reaching end-stage (ESRD). Recent research focuses on finding new therapeutic targets using nanomedicines develop solutions patients. Metal nanoparticle oxides such Zn, Au Ag Oxides, addition synergistic therapy NP combinations Curcumin-Magnesium Oxide (Cur-MgO NPs), Metformin Hollow mesoporous silica cerium oxide nanocomposite particles (MET–HMSN–CeO2 selenium-metformin nanoparticles (Se-NPs- MET), Chitosan-selenium-metformin (Ch-Se-MEF Chitosan-ZnO (ZnO-CS NPs) Silver-chitosan-ascorbic acid (Ag-NCs) show promise they can prevent its progression. article presents comprehensive overview metallic their associated oxides, highlighting remarkable efficacy management DN.
Язык: Английский
Процитировано
0
Kidney & Blood Pressure Research, Год журнала: 2024, Номер 49(1), С. 884 - 897
Опубликована: Окт. 15, 2024
Background: The potential applications of nanotechnology in the medical field have become increasingly recognized recent years. Nanocarriers emerged as a versatile tool, offering wide range due to their unique properties. In addition targeted drugs delivery, nanocarriers also proven be extremely effective imaging and diagnostics. Continuous advances paved way for innovative solutions complex challenges human health, shaping future its applications. Summary: By exploring different types nanoparticles, this review delves into characteristics that can tailored enhance kidney access. Although structural complexity may prevent passage, optimization nanocarrier such shape, size, charge, surface modifications overcome these barriers, allowing delivery. harnessing researchers aim develop efficient therapies address various kidney-related disorders. Key Messages: This highlights promising advancements impact on improving therapeutic outcomes several diseases.
Язык: Английский
Процитировано
0
Journal Of Big Data, Год журнала: 2024, Номер 11(1)
Опубликована: Ноя. 16, 2024
Язык: Английский
Процитировано
0
Nano Today, Год журнала: 2024, Номер 61, С. 102595 - 102595
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
0