Peptide nanozymes: An emerging direction for functional enzyme mimics

Bioactive Materials, Год журнала: 2024, Номер 42, С. 284 - 298

Опубликована: Сен. 4, 2024

Язык: Английский

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Advancements in nanozymes research for the management of chronic wounds

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299

Опубликована: Ноя. 1, 2024

Язык: Английский

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Metal-organic frameworks derived emerging theranostic platforms

Nano Today, Год журнала: 2024, Номер 58, С. 102404 - 102404

Опубликована: Июль 24, 2024

Язык: Английский

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Acid‐Responsive Bacteria‐Targeted Zinc‐Porphyrin Based Sonosensitizer with Enhancing Antibacterial Efficacy and Biofilm Eradication for Infected Wounds Healing

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.

Язык: Английский

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NIR-activating glycyrrhizic acid/carbon nanozyme injectable polysaccharides-based hydrogels for promoting polymicrobial infected wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142082 - 142082

Опубликована: Март 1, 2025

Язык: Английский

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A Targeted Core–Shell ZIF-8/Au@Fe₃O₄ Platform with Multiple Antibacterial Pathways for Infected Skin Wound Regeneration

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Bacterial infections seriously retard skin wound healing. To enhance the antibacterial efficiency and subsequent regeneration, a core-shell structured therapeutic platform, named FZAM, was designed with multiple antimicrobial pathways. FZAM consists of nanosized Fe3O4 as core ZIF-8 loaded Au nanoparticles (NPs) maltodextrin shell. NPs form heterojunction that generates hyperthermia abundant reactive oxide species (ROS) under near-infrared (NIR) irradiation. This also exhibits outstanding peroxidase-like activity. When bacteria invade, plays targeting effect to increase interaction between bacteria, synergistic action NIR-induced ROS well Zn2+ from ZIF-8, kills more than 99% at 200 μg mL-1. Fortunately, is cytocompatible even promotes biofunctions fibroblasts endothelial cells. In infected models, sterilizes NIR irradiation subsequently reduces inflammatory response accelerates regeneration. work provides therapy platform for treating infection assistance helping

Язык: Английский

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A simple two-dimensional metal–organic framework–based phototherapy nanoplatform with a triple-synergistic mechanism for enhanced wound infection treatment

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137656 - 137656

Опубликована: Апрель 1, 2025

Язык: Английский

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Peptide-photosensitizer conjugates: From molecular design to function and antibacterial applications

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162723 - 162723

Опубликована: Апрель 1, 2025

Язык: Английский

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Targeting starvation therapy for diabetic bacterial infections with endogenous enzyme-triggered hyaluronan-modified nanozymes in the infection microenvironment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132277 - 132277

Опубликована: Май 10, 2024

Язык: Английский

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Multiexcitation Peaks and Multicolor Emission Nanoassemblies for Transmembrane Cell Imaging and Photoresponsivity Antibacterial

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5771 - 5779

Опубликована: Авг. 7, 2024

Nanomaterials with photoresponsivity have garnered attention due to their fluorescence imaging, photodynamic, and photothermal therapeutic properties. In this study, a nanoassembly was developed by using photosensitizers carbon dots (CDs). Due multiple excitation peaks multicolor emission, especially membrane-permeating properties, these nanoassemblies can label cells colors track cell imaging in real time. Additionally, the incorporation of CDs provides potential for photodynamic therapy (PDT) (PTT). The effectively suppressed activity

Язык: Английский

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