Smart responsive in situ hydrogel systems applied in bone tissue engineering

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Май 28, 2024

The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with

Язык: Английский

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3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects

Bioactive Materials, Год журнала: 2024, Номер 45, С. 479 - 495

Опубликована: Дек. 5, 2024

Язык: Английский

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Self-sacrificial bioenzyme-reinforced injectable hydrogel bone adhesives for enhancing diabetic fracture healing

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160255 - 160255

Опубликована: Фев. 1, 2025

Язык: Английский

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External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Язык: Английский

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Ultrasound-responsive Smart Biomaterials for Bone Tissue Engineering

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.

Язык: Английский

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3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 24, 2025

Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.

Язык: Английский

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Mechanical and biological properties of 3D printed bone tissue engineering scaffolds

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 4, 2025

Bone defects have historically represented a significant challenge in clinical practice, with traditional surgical intervention remaining the gold standard for their management. However, due to problem of origin autologous and allogeneic bone complex diverse defects, methods sometimes cannot meet treatment needs expectations patients. The development tissue engineering 3D printing technology provides new ideas defect repair. Ideal bioscaffold materials must good mechanical properties, biocompatibility, osteoinduction conduction capabilities. Additionally, factors such as degradation rate, appropriate porosity sustained antibacterial effect be taken into account. combination synthetic composite biomaterial scaffolds has become well-established approach offering innovative solutions combined application seed cells, signalling biological is also beneficial improve therapeutic defects. This article will therefore examine some most commonly used technologies prevalent suitable printing. An analysis conducted on properties these elucidate respective advantages limitations.

Язык: Английский

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Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Апрель 9, 2024

Abstract Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, cutting‐edge bone adhesive is designed, inspired by impressive properties found mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, zinc, gallium‐doped hydroxyapatite nanoparticles. characterized robust catechol–metal coordination which effectively adheres to both hard soft tissues with maximum strength 900 ± 38 kPa on sheep sternum bone, surpassing that commercial adhesives. The release zinc gallium cations from adhesives chitosan matrix imparts remarkable antibacterial promotes rapid blood coagulation, vitro ex vivo. It also proved exhibits significant bioactivity, stable degradability, biocompatibility, ability. Furthermore, capacity adhere tissue support osteogenesis contributes successful healing defect rabbit model summary, these promising characteristics are expected provide solutions clinical issues faced during median

Язык: Английский

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Dynamic Cross-Linking, Self-Healing, Antibacterial Hydrogel for Regenerating Irregular Cranial Bone Defects

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(30), С. 39035 - 39050

Опубликована: Июль 19, 2024

Given the widespread clinical demand, addressing irregular cranial bone defects poses a significant challenge following surgical procedures and traumatic events. In situ-formed injectable hydrogels are attractive for due to their ease of administration ability incorporate ceramics, ions, proteins into hydrogel. this study, multifunctional hydrogel composed oxidized sodium alginate (OSA)-grafted dopamine (DO), carboxymethyl chitosan (CMCS), calcium ions (Ca2+), nanohydroxyapatite (nHA), magnesium oxide (MgO) (DOCMCHM) was prepared address via dynamic Schiff base chelation reactions. DOCMCHM exhibits strong adhesion wet tissues, self-healing properties, antibacterial characteristics. Biological evaluations indicate that has good biocompatibility, in vivo degradability, promote cell proliferation. Importantly, hydrogel, containing MgO, promotes expression osteogenic protein markers COL-1, OCN, RUNX2, stimulates formation new blood vessels by upregulating CD31. This study could provide meaningful insights ion therapy repair defects.

Язык: Английский

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The electrical properties and in vitro osteogenic properties of 3D‐printed MgO@BT/HA piezoelectric ceramic disk

Journal of the American Ceramic Society, Год журнала: 2024, Номер 107(11), С. 7441 - 7451

Опубликована: Июль 22, 2024

Abstract The repair of bone defects from various causes remains a significant challenge in clinical settings. Piezoelectric materials have been demonstrated to promote osteogenic differentiation, among which barium titanate (BT) has widely reported. Magnesium oxide (MgO) dopants not only enhance the piezoelectric properties but also stimulate and angiogenic stem cells. In this study, MgO‐modified BT/hydroxyapatite (MgO@BT/HA) ceramic scaffold was constructed using three‐dimensional (3D)‐printed technology. results indicated that addition MgO improved electrical BT ( d 33 = 68.26 pC/N), facilitated an increase proportion HA (30%) while maintaining coefficient 2.04 pC/N) system. Furthermore, under induction low‐intensity pulsed ultrasound (LIPUS) stimulation, vitro biosafety experiments confirmed MgO@BT/HA exhibits excellent promotes differentiation dental pulp cells (DPSCs).

Язык: Английский

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