The Effect of Nanomechanical Stimulation Strategies on the Shear Piezoelectric Response of Poly(l-lactide) (PLLA) DOI
Richard Schönlein, Pravin Bhattarai, Anup Poudel

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Electrical stimulation has been shown to enhance tissue regeneration, which is why piezoelectric-polymer-based scaffolds are on the rise for advanced tissue-engineering approaches. Recent studies have that electrical cues can modulate cell function in vitro and vivo these be delivered through application of an external noninvasive ultrasound (US) source actuate a piezoelectric polymer. However, poly(l-lactide) (PLLA) possesses shear coefficient therefore requires different strategies US relative other well-established materials such as poly(vinylidene fluoride-trifluoroethylene) P(VDF-TrFE). Thus, this work compares three methods ranging from 1 500 kHz (a nanokicking bioreactor, transducer, bath) PLLA diaphragm with aim creating bioelectrical culture device. The bath stimulated films (37 kHz) generated output voltage 548 ± 16 mV, highest all tested systems. nanokicker (1.3 were associated 4.8 0.7 probe (500 actuated 9.1 0.8 still high enough stimulation. Moreover, influence film tension was examined, reduced observed increase response by 118% reduce P(VDF-TrFE) 24%. This shows PLLA-based designed manner take advantage effect PLLA, when applying

Language: Английский

Smart responsive in situ hydrogel systems applied in bone tissue engineering DOI Creative Commons

Shunli Wu,

Tingting Gai,

Jie Chen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 28, 2024

The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with

Language: Английский

Citations

11
3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair DOI Creative Commons
Bing Li,

Yichao Ma,

Kanwal Fatima

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.

Language: Английский

Citations

1
3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects DOI
Kai Chen,

Fang Wang,

Xiu-Mei Sun

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 479 - 495

Published: Dec. 5, 2024

Language: Английский

Citations

7
Mechano‐Responsive Biomaterials for Bone Organoid Construction DOI Creative Commons
Ruiyang Li, Jian Wang,

Qiushui Lin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract Mechanical force is essential for bone development, homeostasis, and fracture healing. In the past few decades, various biomaterials have been developed to provide mechanical signals that mimic natural microenvironment, thereby promoting regeneration. Bone organoids, emerging as a novel research approach, are 3D micro‐bone tissues possess ability self‐renew self‐organize, exhibiting biomimetic spatial characteristics. Incorporating mechano‐responsive in construction of organoids presents promising avenue simulating microenvironment. Therefore, this review commences by elucidating impact on health, encompassing both cellular interactions alterations structure. Furthermore, most recent applications within realm tissue engineering highlighted. Three different types introduced with focus their responsive mechanisms, strategies, efficacy facilitating Based comprehensive overview, prospective utilization future challenges discussed. As organoid technology advances, these poised become powerful tools

Language: Английский

Citations

6
Dynamic Cross-Linking, Self-Healing, Antibacterial Hydrogel for Regenerating Irregular Cranial Bone Defects DOI
Zuoxiang Dong, Jian Xu, Peng Lun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 39035 - 39050

Published: July 19, 2024

Given the widespread clinical demand, addressing irregular cranial bone defects poses a significant challenge following surgical procedures and traumatic events. In situ-formed injectable hydrogels are attractive for due to their ease of administration ability incorporate ceramics, ions, proteins into hydrogel. this study, multifunctional hydrogel composed oxidized sodium alginate (OSA)-grafted dopamine (DO), carboxymethyl chitosan (CMCS), calcium ions (Ca2+), nanohydroxyapatite (nHA), magnesium oxide (MgO) (DOCMCHM) was prepared address via dynamic Schiff base chelation reactions. DOCMCHM exhibits strong adhesion wet tissues, self-healing properties, antibacterial characteristics. Biological evaluations indicate that has good biocompatibility, in vivo degradability, promote cell proliferation. Importantly, hydrogel, containing MgO, promotes expression osteogenic protein markers COL-1, OCN, RUNX2, stimulates formation new blood vessels by upregulating CD31. This study could provide meaningful insights ion therapy repair defects.

Language: Английский

Citations

5
Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy DOI

Mahshid Shokri,

Mahshid Kharaziha,

Hossein Ahmadi Tafti

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 9, 2024

Abstract Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, cutting‐edge bone adhesive is designed, inspired by impressive properties found mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, zinc, gallium‐doped hydroxyapatite nanoparticles. characterized robust catechol–metal coordination which effectively adheres to both hard soft tissues with maximum strength 900 ± 38 kPa on sheep sternum bone, surpassing that commercial adhesives. The release zinc gallium cations from adhesives chitosan matrix imparts remarkable antibacterial promotes rapid blood coagulation, vitro ex vivo. It also proved exhibits significant bioactivity, stable degradability, biocompatibility, ability. Furthermore, capacity adhere tissue support osteogenesis contributes successful healing defect rabbit model summary, these promising characteristics are expected provide solutions clinical issues faced during median

Language: Английский

Citations

4
Self-sacrificial bioenzyme-reinforced injectable hydrogel bone adhesives for enhancing diabetic fracture healing DOI

Dongming Duan,

Song Liu, Tianhua Xiao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160255 - 160255

Published: Feb. 1, 2025

Language: Английский

Citations

0
External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications DOI
Jing Liao,

Jing-Xi Sun,

Wencong Jia

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Language: Английский

Citations

0
Ultrasound-responsive Smart Biomaterials for Bone Tissue Engineering DOI

Bicheng Ake,

Hongsheng Yang, Hao Yang

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.

Language: Английский

Citations

0
Mechanical and biological properties of 3D printed bone tissue engineering scaffolds DOI Creative Commons

M R Wang,

Yunpeng Xu, Ling Cao

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 4, 2025

Bone defects have historically represented a significant challenge in clinical practice, with traditional surgical intervention remaining the gold standard for their management. However, due to problem of origin autologous and allogeneic bone complex diverse defects, methods sometimes cannot meet treatment needs expectations patients. The development tissue engineering 3D printing technology provides new ideas defect repair. Ideal bioscaffold materials must good mechanical properties, biocompatibility, osteoinduction conduction capabilities. Additionally, factors such as degradation rate, appropriate porosity sustained antibacterial effect be taken into account. combination synthetic composite biomaterial scaffolds has become well-established approach offering innovative solutions combined application seed cells, signalling biological is also beneficial improve therapeutic defects. This article will therefore examine some most commonly used technologies prevalent suitable printing. An analysis conducted on properties these elucidate respective advantages limitations.

Language: Английский

Citations

0