Novel flavonoid derivatives containing benzothiazole as potential antiviral agents: design, synthesis, and biological evaluation DOI Creative Commons

Jiao Tian,

Chunmei Hu, Yuhong Wang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Abstract A series of flavonol derivatives containing benzothiazole were designed and synthesized. The structures all the compounds characterized by NMR HRMS. results bioactivity assay showed that some target possessed outstanding in vivo antiviral activity against tobacco mosaic virus (TMV). Among them, median effective concentration (EC50) L20 was 90.5 µg/mL for curative activities TMV, which better than ningnanmycin (NNM: 252.0 µg/mL). microcalorimetric thermophoresis (MST) molecular docking experiments had a strong binding ability with TMV-CP; malondialdehyde (MDA) superoxide dismutase (SOD) measurements also fully confirmed stimulated plant immune system strengthened plant's resistance to diseases lowering MDA content increasing SOD activity. In addition, chlorophyll test experiment found could reduce destructive effect viruses on chloroplasts, increase chlorophyll, promote photosynthesis. conclusion, above experimental suggested be further investigated as new drugs.

Язык: Английский

Excellent Foliar Deposition of Cyclodextrin‐Encapsulated Furyl/Thienyl‐Engineered Ingredients: Novel Effective Supramolecular Agrochemicals for Combating Plant Bacterial and Fungal Infections DOI

Heju Dai,

Jinghan Yang, Lijun Fan

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(40)

Опубликована: Май 25, 2024

Abstract Repeated epidemics caused by bacterial and fungal diseases pose a threat to global crop yields food security, therefore, updating the structure of existing microbicides improving pesticide bioavailability are challenging tasks, perhaps planning develop versatile supramolecular antimicrobial materials. Here, low‐cost multifunctional complex, named FT6@ β ‐CD, is constructed host‐guest encapsulation thienyl‐engineered ingredient (FT6) into ‐cyclodextrin. This integrated architecture can significantly reduce bounce splash behaviors droplets, improve wetting performance, eventually acquire excellent foliar deposition targeted delivery. Whereafter, ‐CD inhibit transcription type III secretion system (T3SS)‐associated genes, hypersensitive reaction, final pathogenicity from destructive pathogen Xanthomonas oryzae pv. ( Xoo ). Importantly, at lower dosage 200 µg mL −1 , presented in vivo control effects (protection 48.1%, curative 50.1%) against remarkably better than commercial bactericidal formulation thiodiazole‐copper. Additionally, other antifungal materials (FT24/FT25@HP‐ ‐CD/ ‐CD/Me‐ ‐CD) this study effectively treat Botryosphaeria dothidea Botrytis cinerea with higher efficiencies 86.8% 90.1% respectively. provides bright guidance for developing low‐cost, green, eco‐friendly controlling agricultural diseases.

Язык: Английский

Процитировано

9
Discovery of berberine derivatives@chitosan nanoparticles for controlling plant canker diseases DOI
Mei Zhu, Danping Chen, Cheng‐Peng Li

и другие.

Food Hydrocolloids, Год журнала: 2025, Номер unknown, С. 111054 - 111054

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Fabrication of Multifunctional Three‐Component Supramolecular Nano‐Biscuits via Two Macrocycles‐Involved Self‐Assembly for Rice, Citrus and Kiwifruit Protections DOI Creative Commons
Xinyu He, Jinghan Yang,

Xue Chen

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Bacterial plant diseases, worsened by biofilm‐mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three‐component supramolecular nano‐biscuits (NI6R@CB[7]@ β ‐CD) successfully engineered via ordered self‐assembly between two macrocycles [cucurbit[7]uril (CB[7]), ‐cyclodextrin ( ‐CD)] R )‐2‐naphthol‐based bis‐imidazolium bromide salt (NI6R). This macrocycles‐involved bactericidal material combines many advantages. 1) Alleviate the off‐target movement of droplets on hydrophobic blade surfaces. 2) Enhance biofilm‐disrupting ability. At a low‐dose 4.44 µg mL −1 , inhibition rate biofilm formation reached 78.3%. 35.5 potency remove 77.6%. 3) Efficiently hinder bacterial reproduction, swimming, extracellular polysaccharide production, enzyme secretion, virulence plants. These superior characteristics undoubtedly transmitted vivo control effect. 200 this smart exhibits efficiencies 49.6%/65.0%/85.4% against three kinds diseases (rice leaf blight, citrus canker, kiwifruit canker), respectively, surpassing commercial bactericide—thiodiazole‐copper‐20%SC (33.6%/41.5%/43.2%) NI6R (40.3%/51.2%/71.2%). Furthermore, NI6R@CB[7]@ ‐CD is biosafe non‐target organisms. study instructive for constructing sustainable crop protection.

Язык: Английский

Процитировано

0
Development of morphology-dependent nanoselenium carriers for enhancing biological activity and reducing plant stress DOI Creative Commons
Jingyuan Wang, R. Grace Zhai, Yifan Ma

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117804 - 117804

Опубликована: Янв. 30, 2025

Язык: Английский

Процитировано

0
Anticandidal Nanocomposites from Purslane Seed Mucilage Mediated Nanosilver and Nanochitosan DOI Creative Commons
Ahmed A. Tayel,

Ahlam A. S. Aborabu,

Mona Assas

и другие.

Natural Product Communications, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Background: Nanotechnology and nanomaterials are promising approaches for controlling microbial infections. The bio-based nanocomposites provided elevated potentiality against resistant microbes. Method: Nanocomposites comprised purslane “ Portulaceae oleracea L.” seed mucilage (PSM), PSM-mediated silver nanoparticles (PSM/AgNPs) nanochitosan (NCt) were constructed using ecofriendly facile protocol, to be assessed as anticandidal nanostructures Candida albicans. Different NCt: PSM/AgNPs characterized with FTIR, electron microscopies UV spectroscopy. evaluations applied qualitative quantitative assays, followed by scanning microscopy imaging of treated cells. Results: Effectual generation was achieved mean diameter 11.9 nm negative charge (−26.12 mV), whereas the NCt average 232.1 carried positive (+34.65 mV) charges. After different nanocompositing ratio (eg 2:1, 1:1 1:2), these had particles’ diameters 234.5, 173.9 293.7; their surfaces charges +30.63, +24.13 −11.72 mV, respectively. assessing activity revealed that (1:1) strongest actions toward C. albicans strains, which surpassed action fluconazole. images NCt/PSM/AgNPs remarkable distortions/deformation cells within 6 h, ultimate lyses in evidential 12 exposure. Conclusions: influential effectual natural formulations competing pathogenic yeast.

Язык: Английский

Процитировано

0
Discovery of highly effective antiviral agents based on flavonoid-benzothiazole against TMV DOI

Jiao Tian,

Chunmei Hu,

Tianyu Deng

и другие.

Molecular Diversity, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0
Reducing the Phytotoxicity of Tryptanthrin Derivatives for Controlling Plant Bacterial Canker and Wilt Diseases DOI
Mei Zhu, Guiping Ouyang

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Herein, we synthesized 34 novel tryptanthrin derivatives, among which T7NHCO-series compounds showed great antibacterial activity againstXanthomonas axonopodis pv. citri,Pseudomonas syringae actinidiae, andRalstonia solanacearum with EC50 values ranging from 0.26 to 0.56 μg/mL. Meanwhile, these exhibited low cytotoxicity against HEK-293. Additionally, compound T7NHCO can inhibit biofilm formation, damage bacterial morphology, downregulate the expression of chemotaxis-related proteins, cause necrosis, and effectively control citrus kiwifruit canker (the curative protective efficiency is 79.35 88.31%, respectively) diseases. However, a significant phytotoxicity tobacco. Subsequently, based on characteristic tobacco wilt disease being prone outbreak in weakly acidic soil conditions, introduced pH-responsive ZIF-8 drug delivery system. Fortunately, T7NHCO@ZIF-8 nanoparticles noticeable disease. Above all, may be promising green lead agent plant

Язык: Английский

Процитировано

0
A simple approach to fabricate chitosan-delivered avermectin controlled release microparticles for improved efficacy and reduced residues DOI
Xiang‐Ping Kong, Weikun Li, Junhao Liu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140422 - 140422

Опубликована: Янв. 28, 2025

Язык: Английский

Процитировано

0
Design and Synthesis of 3-Carene-Derived Amide-Thiourea/Nanochitosan Complexes with Excellent Laccase Inhibitory Activity and Sustained Releasing Performance for Crop Protection DOI
Yucheng Cui, Wengui Duan,

Guishan Lin

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

The discovery of natural product-derived novel nanopesticide systems can effectively address the adverse effects caused by improper use traditional fungicides. In this research, 33 3-carene-derived amide-thiourea derivatives

Язык: Английский

Процитировано

1
Design and research of new virulence factor inhibitors for plant bacterial disease control DOI Creative Commons
Wei Zeng, Zhiling Sun, Yi Liu

и другие.

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(12), С. 106042 - 106042

Опубликована: Ноя. 4, 2024

Язык: Английский

Процитировано

1