Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 28, 2024
Allergic rhinitis (AR) affects up to 40% of the population, leading significant healthcare expenditures. Current mainstream treatments, while effective, can lead side effects and do not address underlying immunological imbalances.
Язык: Английский
Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(10), С. 2845 - 2916
Опубликована: Июль 13, 2024
Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract
Язык: Английский
Процитировано
23
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156410 - 156410
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 14
Опубликована: Фев. 13, 2025
Objective To analyze the research hotspots and potential of Artificial Intelligence (AI) in cholangiocarcinoma (CCA) through visualization. Methods A comprehensive search publications on application AI CCA from January 1, 2014, to December 31, 2023, within Web Science Core Collection, was conducted, citation information extracted. CiteSpace 6.2.R6 used for visualization analysis information. Results total 736 were included this study. Early primarily focused traditional treatment methods care strategies CCA, but since 2019, there has been a significant shift towards development optimization algorithms their early cancer diagnosis decision-making. China emerged as country with highest volume publications, while Khon Kaen University Thailand academic institution number publications. core group authors involved dense network international collaboration identified. HEPATOLOGY found be most influential journal field. The disciplinary pattern domain exhibits characteristic multiple disciplines intersecting integrating. Conclusion current revolve around three directions: classification preoperative assessment metastasis risk prediction postoperative recurrence CCA. complementarity interdependence among different applications will facilitate future
Язык: Английский
Процитировано
0
Nano Biomedicine and Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3045 - 3065
Опубликована: Март 1, 2025
Abstract: Chinese herbal medicines and their extracts will produce nano-components of charcoal drugs after high-temperature carbonization, the process is similar to that carbon dots (CDs). medicine-derived CDs (CHM-CDs) are a new carbon-based nanomaterial with particle size less than 10 nm discovered in recent years. CHM-CDs possess range beneficial traits, such as minimal toxicity, strong water solubility, superior biocompatibility, remarkable photoluminescence capabilities. Additionally, they exhibit multifaceted pharmacological activity absence drug loading. Over past half-decade, numerous publications have presented evidence suggesting wide array effects. These primarily encompass hemostatic capabilities, neuroprotection, anti-infective, antitumor, immunomodulatory effects hypoglycemic activity. Notably, been associated circulatory system, digestive nervous immune endocrine urinary system skeletal system. This article systematically reviews modern potential mechanisms CHM-CDs, offering insights into current challenges proposing directions for future advancements. As such, it serves vital reference clinical application CHM-CDs. Keywords: medicines, dots, effects,
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106908 - 106908
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Nanoscale Advances, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Chronic wound treatment poses a substantial challenge to healthcare systems. Certain herbal medicines have demonstrated clinical efficacy in promoting chronic healing, yet their therapeutic mechanisms at the molecular level remain elusive due complex composition and multifaceted nature. In this study, Ba-Hao ointment (BHO), sophisticated formulation with diverse ingredients, is selected as model precisely investigate its wound-healing mechanism. Network pharmacology analysis docking simulations reveal that BHO specifically interacts key proteins, including vascular endothelial growth factor A (VEGFA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), suggesting ability modulate critical biological pathways involved inflammation tissue regeneration. Experimental validation further demonstrates significantly promotes cell proliferation, suppresses bacterial infection, enhances expression of essential factors such epidermal (EGF) VEGFA normal human dermal fibroblasts (NHDF), all which are vital for effective healing. vivo studies confirm accelerates closure, reduces inflammation, development well-organized granulation via activation PI3K-Akt signaling pathway. This study interesting since it unveils BHO's role furthering medicine insights.
Язык: Английский
Процитировано
0
Sustainable development and biodiversity, Год журнала: 2025, Номер unknown, С. 205 - 225
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4871 - 4871
Опубликована: Май 19, 2025
Curcumin (Cur) is one of the most studied natural polyphenolic compounds, with many pharmacological properties and a luminescent skeleton. Natural fluorescent molecules are peculiar tools in nanomedicine for bioimaging sensing, this review focuses on photophysical applications Cur these biomedical fields. The first part opens description chemical skeleton its connection nature molecule. 1,6-heptadiene-3,5-dionyl chain causes involvement keto–enol tautomerism, which influences solvatochromism. justifies generation singlet oxygen ROS upon photoexcitation, responsible processes that may be related to photodynamic therapy (PDT) effects Cur. In second review, based derivatives reviewed, deeper attention paid molecular diagnostic nano-formulations involved, either as drug or source fluorescence. Theragnostics an innovative idea medicine integration diagnosis nanotechnology. combination diagnostics provides optimal targeted treatment disease from early stages. has been involved series exploiting characteristics overcoming strong lipophilicity using biocompatible nanomaterials. third modifications were employed synthesize probes change their color response specific stimuli consequence trapping molecules. Finally, methodologies sensing biothiols, anions, cations by described, common features such reveal how each modification can deeply influence luminescence.
Язык: Английский
Процитировано
0
Systematic Reviews, Год журнала: 2024, Номер 13(1)
Опубликована: Май 30, 2024
Functional endoscopic sinus surgery is a principal option for treating chronic rhinosinusitis with nasal polyps (CRSwNP) after medication failures. Unfortunately, some patients still have unsatisfactory postoperative recovery. The type of inflammatory cell infiltration in polyp tissue has been reported available recurrence prediction. As it invasive and time-consuming, this technique hard to promote clinically under the existing technical conditions. And during course clinical treatment, we noted that differences rate present among different traditional Chinese medicine syndrome types.
Язык: Английский
Процитировано
1