Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 28, 2024
Allergic rhinitis (AR) affects up to 40% of the population, leading significant healthcare expenditures. Current mainstream treatments, while effective, can lead side effects and do not address underlying immunological imbalances.
Language: Английский
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916
Published: July 13, 2024
Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract
Language: Английский
Citations
22
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156410 - 156410
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Feb. 13, 2025
Objective To analyze the research hotspots and potential of Artificial Intelligence (AI) in cholangiocarcinoma (CCA) through visualization. Methods A comprehensive search publications on application AI CCA from January 1, 2014, to December 31, 2023, within Web Science Core Collection, was conducted, citation information extracted. CiteSpace 6.2.R6 used for visualization analysis information. Results total 736 were included this study. Early primarily focused traditional treatment methods care strategies CCA, but since 2019, there has been a significant shift towards development optimization algorithms their early cancer diagnosis decision-making. China emerged as country with highest volume publications, while Khon Kaen University Thailand academic institution number publications. core group authors involved dense network international collaboration identified. HEPATOLOGY found be most influential journal field. The disciplinary pattern domain exhibits characteristic multiple disciplines intersecting integrating. Conclusion current revolve around three directions: classification preoperative assessment metastasis risk prediction postoperative recurrence CCA. complementarity interdependence among different applications will facilitate future
Language: Английский
Citations
0
Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3045 - 3065
Published: March 1, 2025
Abstract: Chinese herbal medicines and their extracts will produce nano-components of charcoal drugs after high-temperature carbonization, the process is similar to that carbon dots (CDs). medicine-derived CDs (CHM-CDs) are a new carbon-based nanomaterial with particle size less than 10 nm discovered in recent years. CHM-CDs possess range beneficial traits, such as minimal toxicity, strong water solubility, superior biocompatibility, remarkable photoluminescence capabilities. Additionally, they exhibit multifaceted pharmacological activity absence drug loading. Over past half-decade, numerous publications have presented evidence suggesting wide array effects. These primarily encompass hemostatic capabilities, neuroprotection, anti-infective, antitumor, immunomodulatory effects hypoglycemic activity. Notably, been associated circulatory system, digestive nervous immune endocrine urinary system skeletal system. This article systematically reviews modern potential mechanisms CHM-CDs, offering insights into current challenges proposing directions for future advancements. As such, it serves vital reference clinical application CHM-CDs. Keywords: medicines, dots, effects,
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106908 - 106908
Published: April 1, 2025
Language: Английский
Citations
0
Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Chronic wound treatment poses a substantial challenge to healthcare systems. Certain herbal medicines have demonstrated clinical efficacy in promoting chronic healing, yet their therapeutic mechanisms at the molecular level remain elusive due complex composition and multifaceted nature. In this study, Ba-Hao ointment (BHO), sophisticated formulation with diverse ingredients, is selected as model precisely investigate its wound-healing mechanism. Network pharmacology analysis docking simulations reveal that BHO specifically interacts key proteins, including vascular endothelial growth factor A (VEGFA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), suggesting ability modulate critical biological pathways involved inflammation tissue regeneration. Experimental validation further demonstrates significantly promotes cell proliferation, suppresses bacterial infection, enhances expression of essential factors such epidermal (EGF) VEGFA normal human dermal fibroblasts (NHDF), all which are vital for effective healing. vivo studies confirm accelerates closure, reduces inflammation, development well-organized granulation via activation PI3K-Akt signaling pathway. This study interesting since it unveils BHO's role furthering medicine insights.
Language: Английский
Citations
0
Sustainable development and biodiversity, Journal Year: 2025, Volume and Issue: unknown, P. 205 - 225
Published: Jan. 1, 2025
Language: Английский
Citations
0
Systematic Reviews, Journal Year: 2024, Volume and Issue: 13(1)
Published: May 30, 2024
Functional endoscopic sinus surgery is a principal option for treating chronic rhinosinusitis with nasal polyps (CRSwNP) after medication failures. Unfortunately, some patients still have unsatisfactory postoperative recovery. The type of inflammatory cell infiltration in polyp tissue has been reported available recurrence prediction. As it invasive and time-consuming, this technique hard to promote clinically under the existing technical conditions. And during course clinical treatment, we noted that differences rate present among different traditional Chinese medicine syndrome types.
Language: Английский
Citations
1
Current Nutrition & Food Science, Journal Year: 2024, Volume and Issue: 21(3), P. 282 - 294
Published: Aug. 12, 2024
The process known as “programmed cell death” is referred to “apoptosis,” a term frequently used in scientific research. Typically, the body's own system eliminates damaged cells by identifying defective ones and activating their destruction response various signals. However, if its precise mechanisms are understood, apoptosis can also be intentionally induced external factors. Herbal substances have been found contain ingredients that trigger apoptosis. Breast cancer, highly fatal condition, caused uncontrolled division of abnormal cells. This underlying cause disease. Currently, there no ideal solution this problem. has potential effective therapeutic strategy for treating devastating In near future, herbal medicines could treat breast cancer inducing tumor These treatments offer fewer adverse reactions compared current chemical therapies, which often numerous unwanted side effects. review article examines remedies studies effectively induce significant because it highlights focus on cancer. underscores importance exploring natural developing safer more lethal
Language: Английский
Citations
0