Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1184 - 1184
Опубликована: Март 6, 2025
Flavonoids
represent
a
class
of
natural
plant
secondary
metabolites
with
multiple
activities
including
antioxidant,
antitumor,
anti-inflammatory,
and
antimicrobial
properties.
However,
due
to
their
structural
characteristics,
they
often
exhibit
low
bioavailability
in
vivo.
In
this
review,
we
focus
on
the
vivo
study
flavonoids,
particularly
effects
gut
microbiome
common
modifications
such
as
methylation,
acetylation,
dehydroxylation,
etc.
These
aim
change
characteristics
original
substances
enhance
absorption
bioavailability.
order
improve
discuss
two
feasible
methods,
namely
dosage
form
modification
chemical
modification,
hope
that
these
approaches
will
offer
new
insights
into
application
flavonoids
for
human
health.
article,
also
introduce
types,
sources,
efficacy
flavonoids.
conclusion,
is
comprehensive
review
how
Язык: Английский
Kaempferol Alleviates Hepatic Injury in Nonalcoholic Steatohepatitis (NASH) by Suppressing Neutrophil-Mediated NLRP3-ASC/TMS1-Caspase 3 Signaling
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2630 - 2630
Опубликована: Июнь 3, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
significant
hepatic
condition
that
has
gained
worldwide
attention.
Kaempferol
(Kae),
renowned
for
its
diverse
biological
activities,
including
anti-inflammatory,
antioxidant,
anti-aging,
and
cardio-protective
properties,
emerged
as
potential
therapeutic
candidate
non-alcoholic
steatohepatitis
(NASH).
Despite
promising
potential,
the
precise
underlying
mechanism
of
Kae's
beneficial
effects
in
NASH
remains
unclear.
Therefore,
this
study
aims
to
clarify
by
conducting
comprehensive
vivo
vitro
experiments.
Язык: Английский
From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 29, 2025
Acute
pancreatitis
(AP)
is
a
disease
characterized
by
an
acute
inflammatory
response
in
the
pancreas.
This
caused
abnormal
activation
of
pancreatic
enzymes
variety
etiologic
factors,
which
results
localized
response.
The
symptoms
this
include
abdominal
pain,
nausea
and
vomiting
fever.
These
are
induced
hyperinflammatory
oxidative
stress.
In
recent
years,
research
has
focused
on
developing
anti-inflammatory
antioxidative
therapies
for
treatment
(AP).
However,
there
still
limitations
to
approach,
including
poor
drug
stability,
low
bioavailability
short
half-life.
advent
nanotechnology
opened
up
novel
avenue
management
Nanomaterials
can
serve
as
efficacious
vehicle
conventional
pharmaceuticals,
enhancing
their
targeting
ability,
improving
prolonging
Moreover,
they
also
exert
direct
therapeutic
effect.
review
begins
introducing
general
situation
It
then
discusses
pathogenesis
current
status
treatment.
Finally,
it
considers
literature
related
nanomaterials.
objective
study
provide
comprehensive
existing
use
nanomaterials
particular,
changes
markers
outcomes
following
administration
examined.
done
with
intention
offering
insights
that
inform
subsequent
facilitate
clinical
application
Язык: Английский
Microenvironment responsive nanomedicine for acute pancreatitis treatment
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
unknown, С. 114633 - 114633
Опубликована: Март 1, 2025
Язык: Английский
Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Severe
acute
pancreatitis
(SAP)
is
a
critical
inflammatory
disease
with
high
morbidity
and
mortality.
Current
treatments
focused
on
symptomatic
relief
but
failed
to
prevent
inflammation
progression
in
cellular
level.
In
order
develop
an
SAP-targeting
drug
delivery
system
alleviate
SAP
level
illustrate
its
mechanism,
we
explored
the
use
of
proanthocyanidin
(PYD)
pentoxifylline
(PTX)
loaded
into
macrophage
membrane-coated
self-assembly
nanoparticles
(FePTX@CM
NPs)
for
targeted
treatment.
The
combination
application
these
two
drugs
was
innovative
aid.
We
developed
NPs
by
strategy
cell
membrane
coating.
Its
particle
size
zeta
potential
were
measured
dynamic
light
scatter
(DLS).
morphology
observed
transmission
electron
microscopy
(TEM).
And
encapsulation
efficiency
evaluated
nano-flow
cytometry.
total
protein
profile
determined
via
Coomassie
brilliant
blue.
explore
mechanism
our
against
animal
levels.
Bioinformatics
approaches,
TEM,
immunofluorescent
assay
co-immunoprecipitation
performed
comprehensively
explain
specific
anti-SAP
FePTX@CM
NPs.
After
inflammation-driven
targeting,
PYD
inhibited
pancreatic
amylase
lipase
release
suppressing
mitochondrial
reactive
oxygen
species
(mtROS)/Golgi
stress,
while
PTX
prevented
SAP-associated
PANoptosis
inhibiting
Zbp1
signal
pathway.
protection
effect
biomimetic
worked
from
different
aspects
symptoms
relative
cells.
demonstrated
effective
pancreas
reduced
systemic
especially
pro-inflammatory
recruitment
activation,
minimized
tissue
damage
mouse
models,
offering
promising
therapeutic
clinical
management.
Язык: Английский
Astragalus in Acute Pancreatitis: Insights from Network Pharmacology, Molecular Docking, and Meta-Analysis Validation
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(5), С. 379 - 379
Опубликована: Май 21, 2025
(1)
Backgroud
Astragalus,
a
traditional
Chinese
medicine,
demonstrates
therapeutic
effectiveness
in
acute
pancreatitis
(AP).
Nevertheless,
its
precise
pharmacological
mechanism
remains
unclear,
and
clinical
guidelines
have
not
been
established.
This
study
aims
to
systematically
elucidate
the
active
compounds
molecular
mechanisms
underlying
Astragalus’
effects
AP,
provide
evidence
supporting
efficacy.
(2)
Methods:
TCMSP
Swiss
Target
Prediction
identified
drug
targets;
GeneCards,
DrugBank,
OMIM
provided
disease
targets.
Venny
determined
targets,
while
STRING
constructed
protein–protein
interaction
network.
Cytoscape
3.10.3
validated
core
DAVID
was
used
conduct
GO
KEGG
pathway
analyses,
visualized
via
Bioinformatic
platform.
build
“drug–ingredients–targets–pathways–disease”
AutoDock
Vina
1.1.2
AutoDockTools
1.5.7
performed
docking,
with
PyMOL
3.0
visualizing
results.
PubMed,
Embase,
Cochrane,
Web
of
Science,
CNKI,
Wanfang,
VIP,
CBMdisc
were
searched.
The
literature
screened,
extracted,
evaluated,
followed
by
meta-analysis,
using
RevMan
5.4.1
Stata
18.
(3)
Results:
We
539
targets
for
ingredients
astragalus.
Among
1974
disease-related
232
found
be
analysis
yielded
589
entries,
enrichment
147
relevant
pathways.
top
five
quercetin,
kaempferol,
isorhamnetin,
formononetin,
calycosin.
Molecular
docking
revealed
potential
synergistic
between
these
components
comprising
six
randomized
controlled
trials,
demonstrated
significantly
higher
total
effective
rate
efficacy
astragalus
group
compared
control
group.
(4)
Conclusions:
Astragalus
treats
AP
through
action
components,
Key
compounds,
such
as
calycosin,
engage
pivotal
including
TP53,
AKT1,
TNF,
IL6,
EGFR,
CASP3,
MYC,
HIF1A,
within
primary
pathways,
pathways
cancer,
PI3K-Akt
signaling
pathway,
lipid
metabolism,
atherosclerosis.
effectively
alleviates
symptoms
reducing
time
gas
or
defecation
passage,
disappearance
abdominal
pain
distension,
recovery
bowel
sounds.
Язык: Английский
Targeting the programmed cell death signaling mechanism with natural products for the treatment of acute pancreatitis: a review
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 30, 2025
Acute
pancreatitis
(AP)
is
a
common
critical
disease
in
clinical
practice,
characterized
by
acute
onset,
rapid
progression,
aggressive
conditions,
and
high
lethality.
Pancreatic
acinar
cell
death
central
event
the
pathological
process
of
AP
key
factor
determining
extent
local
or
systemic
inflammatory
injury
overall
prognosis.
Programmed
(PCD)
form
active
regulated
multiple
genes,
including
apoptosis,
autophagy,
ferroptosis,
pyroptosis,
necroptosis.
PCD
plays
role
eliminating
unwanted
organisms
damaged
cells,
which
great
significance.
Numerous
studies
have
demonstrated
strong
association
between
various
forms
AP,
targeted
interventions
signaling
pathways
targets
can
influence
progression
AP.
Furthermore,
existing
research
indicates
that
natural
products
sourced
from
plants,
fruits,
vegetables
exhibit
considerable
potential
targeting
regulating
for
treatment
Therefore,
this
paper
focuses
on
summarizing
types
discusses
specific
reported
using
products.
This
review
aims
to
provide
reference
guiding
lay
foundation
developing
new
drugs
effectively
prevent
manage
Язык: Английский
Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Acute
pancreatitis
(AP)
is
an
inflammatory
disease
of
the
pancreas
and
a
complex
process
involving
multiple
factors,
with
mitochondrial
damage
playing
crucial
role.
Mitochondrial
dysfunction
now
considered
key
driver
in
development
AP.
This
often
presents
as
increased
oxidative
stress,
altered
membrane
potential
permeability,
DNA
mutations.
Under
stress
conditions,
dynamics
ROS
production
increase,
leading
to
decreased
potential,
imbalanced
calcium
homeostasis,
activation
permeability
transition
pore.
The
release
(mtDNA),
recognized
damage-associated
molecular
patterns,
can
activate
cGAS-STING1
NF-κB
pathway
induce
pro-inflammatory
factor
expression.
Additionally,
mtDNA
inflammasomes,
interleukin
subsequent
tissue
inflammation.
review
summarizes
relationship
between
mitochondria
AP
explores
protective
strategies
diagnosis
treatment
this
disease.
Future
research
on
acute
benefit
from
exploring
promising
avenues
such
antioxidants,
inhibitors,
new
therapies
that
target
dysfunction.
Язык: Английский
Therapeutic potential of plant polyphenols in acute pancreatitis
Inflammopharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Язык: Английский
Synthesis and Antioxidant Effects of Edaravone-Loaded MPEG-2000-DSPE Micelles in Rotenone-Induced PC12 Cell Model of Parkinson’s Disease
Nanomaterials,
Год журнала:
2024,
Номер
14(23), С. 1962 - 1962
Опубликована: Дек. 6, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder
globally
that
lacks
any
disease-modifying
drug
for
prevention
or
treatment.
Oxidative
stress
has
been
identified
as
one
of
key
pathogenic
drivers
(PD).
Edaravone,
an
approved
free-radical
scavenger,
proven
to
have
potential
against
PD
by
targeting
multiple
pathologies,
including
oxidative
stress,
focal
mitochondria,
and
neuroinflammation.
However,
its
bioavailability
potentially
restricted
due
poor
solubility
short
half-life.
This
study
aims
develop
a
simple
effective
delivery
system
edaravone
enhance
solubility,
stability,
improve
neuroprotective
efficacy.
An
MPEG-2000-DSPE-edaravone
(MDE)
micelle
was
prepared
via
solvent
evaporation
using
MPEG-2000-DSPE
carrier
encapsulate
edaravone.
The
morphology,
particle
size,
zeta
potential,
chemical
structure,
loading
MDE
were
evaluated.
We
then
investigated
whether
such
targeted
could
provide
enhanced
neuroprotection.
A
cell
model
established
in
PC12
cells
through
exposure
rotenone.
effects
on
treated
with
without
rotenone
evaluated
counting
kit-8,
calcein
acetoxymethyl
ester
(AM)-propidine
iodide
(PI)
staining,
flow
cytometry.
Cell
migration
wound
healing
assay.
Additionally,
intracellular
antioxidant
performed
ROS-level-detecting
DCFH-DA
probe,
mitochondrial
membrane
potentials
JC-1
drug-loading
content
17.6%
encapsulation
efficiency
92.8%
successfully
prepared.
resultant
had
mean
size
112.97
±
5.54
nm
-42
mV.
Cytotoxicity
assays
confirmed
(≤200
ug/mL)
exhibited
promising
cytocompatibility
no
significant
effect
viability,
cycle
regulation,
apoptosis
levels.
Likewise,
compared
free
edaravone,
noted
MDE.
might
be
able
target
into
cells,
increasing
providing
local
effect.
results
demonstrated
material
enhancing
edaravone's
aqueous
effects.
formulation
treating
other
diseases
which
plays
role
pathogenesis.
Язык: Английский