Exosomes: A Promising Drug Delivery Tool in Hepatic Drug Delivery
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106761 - 106761
Опубликована: Март 1, 2025
Язык: Английский
Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 12, 2025
Excessive
generation
of
reactive
oxygen
species
is
a
hallmark
the
osteoporotic
bone
microenvironment,
which
leads
to
damage
mitochondrial
function
and
deactivation
osteoblasts.
Fruits
vegetables
are
rich
sources
antioxidants,
play
key
role
in
scavenging
free
radicals
maintaining
body's
homeostasis.
Herein,
we
have
developed
type
vesicle
coming
from
carrots
as
nanoantioxidants
counteract
oxidative
stress
restore
vitality
osteoblasts
for
reversing
osteoporosis.
Nanovesicles
derived
carrot
juice
using
straightforward
extrusion
method,
resulting
stable
membrane
structures
containing
various
lipids
homologous
active
phytochemicals.
can
maintain
under
normal
physiological
conditions
(pH
7.4)
transform
into
aggregates
response
acidic
extracellular
pH
osteoporosis
4.0).
As
anticipated,
nanovesicles
passively
target
aggregate
bone,
ease
stress,
function,
promote
osteoblastogenesis,
reduce
loss
mice.
This
work
presents
first
demonstration
novel
realize
long-awaited
osteogenesis,
contributing
exploration
brand-new
idea
Язык: Английский
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12793 - 12815
Опубликована: Ноя. 1, 2024
Plant-derived
exosome-like
nanovesicles
(PELNs)
from
edible
plants,
isolated
by
ultracentrifugation,
size
exclusion
chromatography
or
other
methods,
were
proved
to
contain
a
variety
of
biologically
active
and
therapeutically
specific
components.
Recently,
investigations
in
the
field
PELN-based
biomedicine
have
been
conducted,
which
positioned
those
as
promising
tools
for
prevention
treatment
several
diseases,
with
their
natural
origin
potentially
offering
superior
biocompatibility
bioavailability.
However,
inadequate
targeting
limited
therapeutic
effects
constrain
utility
clinical
translation
PELNs.
Thus,
strategies
aiming
at
bridging
gap
engineering
PELNs
great
interest.
Those
approaches
include
membrane
hybridization,
physical
chemical
surface
functionalization
encapsulation
payloads.
Herein,
we
provide
comprehensive
overview
biogenesis
composition,
isolation
purification
methods
characterization
PELNs,
well
functions.
Current
knowledge
on
construction
biomedical
application
engineered
reviewed.
Additionally,
future
directions
perspectives
this
discussed
order
further
enrich
expand
prospects
Язык: Английский
Comparison of nanovesicles derived from Panax notoginseng at different size: physical properties, composition, and bioactivity
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 22, 2024
Aim
Plant-derived
nanovesicles
have
emerged
as
potential
agents
for
combating
tumors.
In
this
study,
we
investigated
the
inhibitory
effects
of
Panax
notoginseng
-derived
(PnNVs)
on
proliferation
and
migration
squamous
cell
carcinoma.
Additionally,
explored
relationship
between
plant
tuber
size
physical
properties,
composition
bioactivity
these
nanovesicles.
Methods
We
isolated
PnNVs
from
tubers
varying
sizes:
small-sized
(s_PnNVs),
medium-sized
(m_PnNVs)
large-sized
(l_PnNVs),
evaluated
size,
potential,
morphology.
Cellular
uptake
efficiency
was
assessed
using
confocal
microscopy
flow
cytometry.
The
ability
different
to
inhibit
oral
carcinoma
cells
plate
cloning,
CCK8
assay,
scratch
healing
assay.
Off-target
metabolomics
used
compare
metabolic
compounds
PnNVs.
Results
Our
findings
revealed
that
s_PnNVs
exhibited
lower
but
had
highest
cellular
efficiency,
whereas
m_PnNVs
were
characterized
by
smallest
lowest
efficiency.
Notably,
demonstrated
most
effective
inhibition
growth
migration.
Compositional
analyses
showed
rich
in
proteins
contained
levels
RNA,
with
l_PnNVs
having
protein
content.
Furthermore,
untargeted
analysis
a
significant
increase
expression
specific
antitumour-related
metabolites
compared
l_PnNVs.
Conclusion
Overall,
our
results
underscore
influence
which
they
are
derived,
emphasizing
its
importance
experimental
design
study
reproducibility.
Язык: Английский