Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
skeleton
is
highly
innervated
by
numerous
nerve
fibers.
These
fibers,
in
addition
to
transmitting
information
within
the
bone
and
mediating
sensations,
play
a
crucial
role
regulating
tissue
formation
regeneration.
Traditional
engineering
(BTE)
often
fails
achieve
satisfactory
outcomes
when
dealing
with
large-scale
defects,
which
frequently
related
lack
of
effective
reconstruction
neurovascular
network.
In
recent
years,
increasing
research
has
revealed
critical
nerves
metabolism.
Nerve
fibers
regulate
cells
through
neurotransmitters,
neuropeptides,
peripheral
glial
cells.
Furthermore,
also
coordinate
vascular
immune
systems
jointly
construct
microenvironment
favorable
for
As
signaling
driver
formation,
neuroregulation
spans
entire
process
physiological
activities
from
embryonic
postmaturity
remodeling
repair.
However,
there
currently
comprehensive
summaries
these
regulatory
mechanisms.
Therefore,
this
review
sketches
out
function
during
Then,
we
elaborate
on
mechanisms
coupling
neuromodulation
immunity.
Finally,
discuss
several
novel
strategies
neuro-bone
(NBTE)
based
bone,
focusing
coordinated
regeneration
tissue.
Язык: Английский
Strategies for promoting neurovascularization in bone regeneration
Military Medical Research,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
Язык: Английский
The application of stem cells and exosomes in promoting nerve conduits for peripheral nerve repair
Biomaterials Research,
Год журнала:
2025,
Номер
29
Опубликована: Янв. 1, 2025
The
repair
of
peripheral
nerve
injury
(PNI)
presents
a
multifaceted
and
protracted
challenge,
with
current
therapeutic
approaches
failing
to
achieve
optimal
outcomes,
thereby
not
satisfying
the
considerable
clinical
demand.
advent
tissue
engineering
has
led
growing
body
experimental
evidence
indicating
that
synergistic
application
conduits,
which
provide
structural
guidance,
alongside
biological
signals
derived
from
exosomes
stem
cells,
yields
superior
results
for
PNI
compared
isolated
interventions.
This
combined
approach
holds
great
promise
application.
In
this
review,
we
present
latest
advancements
in
treatment
through
integration
cells
or
conduits.
We
have
addressed
inadequate
efficiency
conjunction
conduits
3
perspectives:
enhancing
exosomes,
improving
incorporating
physical
stimulation.
Язык: Английский
The Role of Endothelial Cell Glycolysis in Schwann Cells and Peripheral Nerve Injury Repair: A Novel and Important Research Area
Li‐Xin Huang,
Tao Sun,
Jun Sun
и другие.
Neurochemical Research,
Год журнала:
2025,
Номер
50(2)
Опубликована: Март 18, 2025
Язык: Английский
Ultrasound‐Driven Innervated Bone Regeneration in Additively Manufactured Degradable Metallic Scaffolds
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Abstract
Bone
tissues
are
densely
innervated
by
nerve
fibers
throughout
the
periosteum
and
mineralized
bone.
The
impairment
of
bone
regeneration
is
a
critical
factor
contributing
to
challenges
in
osteoporotic
remodeling
repair.
Herein,
an
“ultrasound‐driven
regeneration”
strategy
proposed
additively
manufactured
degradable
Zn‐Cu
scaffolds.
vitro
investigations
with
RSC96
cells
elucidated
synergistic
promotion
low‐intensity
pulsed
ultrasound
(LIPUS)
metal
cations
on
Schwann
cell
proliferation
exosome
secretion.
Notably,
these
cell‐derived
exosomes,
once
internalized
neighboring
marrow
stromal
(BMSCs),
significantly
enhanced
their
migration,
osteogenic
differentiation,
extracellular
matrix
deposition,
indicating
potent
mechanism
for
regeneration.
Furthermore,
vivo
evaluation
validated
that
LIPUS
stimulation
activated
S100β‐positive
facilitated
peripheral
within
cranial
defects,
leading
accelerated
healing
rats
implantation
over
2‐
6‐week
recovery
periods.
This
work
provides
focusing
activation
enhancement
paracrine
effect,
especially
secretion,
which
further
recruited
surrounding
BMSCs
promoted
differentiation.
study
holds
considerable
promise
clinical
applications
translation
treatment
defects.
Язык: Английский
Molecular and Cellular Mechanisms Underlying Peripheral Nerve Injury-Induced Cellular Ecological Shifts: Implications for Neuroregeneration
IBRO Neuroscience Reports,
Год журнала:
2024,
Номер
18, С. 120 - 129
Опубликована: Дек. 28, 2024
The
peripheral
nervous
system
is
a
complex
ecological
network,
and
its
injury
triggers
series
of
fine-grained
intercellular
regulations
that
play
crucial
role
in
the
repair
process.
sophisticated
initiates
cascade
intricate
regulatory
processes
are
instrumental
Despite
advent
microsurgical
techniques,
nerve
injuries
frequently
proves
inadequate,
resulting
adverse
effects
on
patients'
quality
life.
Accordingly,
continued
pursuit
more
efficacious
treatments
paramount
importance.
In
this
paper,
review
relevant
literature
from
recent
years
was
conducted
to
identify
key
cell
types
involved
after
injury.
These
included
Schwann
cells,
macrophages,
neutrophils,
endothelial
fibroblasts.
depth.
This
paper
analyses
phenotypic
changes
these
cells
injury,
factors
affecting
changes,
how
they
coordinate
with
neurons
other
types.
addition,
it
explores
potential
mechanisms
mediate
behaviour
cells.
Understanding
interactions
between
their
mutual
regulation
great
significance
for
discovery
new
neuroregenerative
identification
therapeutic
targets.
Язык: Английский
Therapeutic effect of exosomes derived from SCs in the repair of peripheral nerve injury
Life Sciences,
Год журнала:
2024,
Номер
357, С. 123086 - 123086
Опубликована: Сен. 30, 2024
Язык: Английский
ATP5J regulates microglial activation via mitochondrial dysfunction, exacerbating neuroinflammation in intracerebral hemorrhage
Naixin Ren,
Hutao Zhang,
Tao Li
и другие.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 13, 2024
Microglial-mediated
neuroinflammation
is
crucial
in
the
pathophysiological
mechanisms
of
secondary
brain
injury
(SBI)
following
intracerebral
hemorrhage
(ICH).
Mitochondria
are
central
regulators
inflammation,
influencing
key
pathways
such
as
alternative
splicing,
and
play
a
critical
role
cell
differentiation
function.
Mitochondrial
ATP
synthase
coupling
factor
6
(ATP5J)
participates
various
pathological
processes,
proliferation,
migration,
inflammation.
However,
ATP5J
microglial
activation
post-ICH
poorly
understood.
This
study
aimed
to
investigate
effects
on
subsequent
ICH
elucidate
underlying
mechanisms.
We
observed
that
was
upregulated
microglia
after
ICH.
AAV9-mediated
overexpression
worsened
neurobehavioral
deficits,
disrupted
blood-brain
barrier,
increased
water
content
mice.
Conversely,
knockdown
ameliorated
these
effects.
also
intensified
activation,
neuronal
apoptosis,
inflammatory
responses
surrounding
tissues
post-ICH.
impaired
dynamics
reduced
proliferation
migration
sites.
used
oxyhemoglobin
(OxyHb)
stimulate
BV2
cells
model
vitro
.
Further
studies
showed
enhanced
OxyHb-induced
functional
transformation.
Mechanistically,
silencing
reversed
dynamin-related
protein
1
(Drp1)
mitochondrial
fission
(Fis1)
upregulation
post-OxyHb
induction;
overdivision,
excessive
permeability
transition
pore
opening,
reactive
oxygen
species
production;
restored
normal
ridge
morphology;
partially
respiratory
electron
transport
chain
activity.
further
alleviated
dysfunction
by
regulating
metabolism.
Our
results
indicate
transformation
modulating
metabolism,
thereby
positively
regulate
neuroinflammation.
By
inhibiting
ATP5J,
SBI
could
be
prevented.
Therefore,
candidate
for
molecular
therapeutic
target
exploration
alleviate
Язык: Английский