Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 30, 2025
Язык: Английский
Recent advances in nanomedicine therapy for bacterial pneumonia
Chinese Chemical Letters,
Год журнала:
2025,
Номер
unknown, С. 110920 - 110920
Опубликована: Фев. 1, 2025
Язык: Английский
Pathophysiological mechanisms of ARDS: a narrative review from molecular to organ-level perspectives
Respiratory Research,
Год журнала:
2025,
Номер
26(1)
Опубликована: Фев. 13, 2025
Acute
respiratory
distress
syndrome
(ARDS)
remains
a
life-threatening
pulmonary
condition
with
persistently
high
mortality
rates
despite
significant
advancements
in
supportive
care.
Its
complex
pathophysiology
involves
an
intricate
interplay
of
molecular
and
cellular
processes,
including
cytokine
storms,
oxidative
stress,
programmed
cell
death,
disruption
the
alveolar-capillary
barrier.
These
mechanisms
drive
localized
lung
injury
contribute
to
systemic
inflammatory
response
multiple
organ
dysfunction
syndrome.
Unlike
prior
reviews
that
primarily
focus
on
isolated
mechanisms,
this
narrative
review
synthesizes
key
pathophysiological
processes
ARDS
across
molecular,
cellular,
tissue,
levels.
By
integrating
classical
theories
recent
research
advancements,
we
provide
comprehensive
analysis
how
mediators,
metabolic
reprogramming,
immune
dysregulation
synergistically
onset
progression.
Furthermore,
critically
evaluate
current
evidence-based
therapeutic
strategies,
such
as
lung-protective
ventilation
prone
positioning,
while
exploring
innovative
therapies,
stem
therapy,
gene
immunotherapy.
We
emphasize
significance
subtypes
their
inherent
heterogeneity
guiding
development
personalized
treatment
strategies.
This
provides
fresh
perspectives
for
future
research,
ultimately
enhancing
patient
outcomes
optimizing
management
approaches
ARDS.
Язык: Английский
Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Abstract
Acute
lung
injury
(ALI)
refers
to
damage
related
cells,
typically
caused
by
an
uncontrollable
inflammatory
response,
and
over‐generated
reactive
oxygen
species
(ROS).
Increasing
evidence
suggests
that
reprogramming
redox
homeostasis
holds
significant
potentials
for
the
clinical
treatment
of
ALI.
Herein,
simple
synthesis
ultra‐small
Pd
loaded
covalent
organic
framework
(COF)
(TP@Pd)
is
reported,
which,
when
combined
with
near
infrared
(NIR)
irradiation,
exhibits
nanozyme
functionalities,
including
multiple
enzyme
mimicking
activities
broad
spectrum
ROS
scavenging,
thereby
promoting
tissue
repair
ALI
immunotherapy.
Mechanistically,
through
therapeutic
strategy
TP@Pd+NIR,
damaged
cells
tissues
are
ameliorated
decreasing
intracellular
levels
(total
ROS,
·OH
·O
2
−
),
downregulating
cytokines
(IL‐6,
TNF‐α
IL‐1β),
upregulating
antioxidant
factor
level
(SOD2),
inducing
macrophage
M2
directional
polarization
(downregulation
iNOS
CD86,
upregulation
IL‐10
CD206),
activating
immunoregulation
(CD4
+
/CD8
ratio
increase),
(upregulation
HSP70
CD31),
suppressing
NF‐κB
signaling
pathway
phosphorylated
p65
IκBα).
Furthermore,
following
intravenous
(IV)
injection
in
rats,
TP@Pd
accumulated
6
h,
indicating
promising
efficacy
via
this
administration
route.
Notably,
TP@Pd+NIR
demonstrated
excellent
synergistic
effects
alleviating
inflammation
storms,
reducing
diffuse
alveolar
damage,
accelerating
repair.
Summarily,
work
has
designed
a
novel
enhancement
amelioration,
which
may
serve
as
approach
other
diseases.
Язык: Английский
The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal
cancer
poses
a
significant
threat
to
human
health
due
its
high
aggressiveness
and
poor
prognosis.
Key
factors
impacting
patient
outcomes
include
post-surgical
recurrence,
chemotherapeutic
drug
resistance,
insensitivity
immunotherapy.
Consequently,
early
diagnosis
the
development
of
effective
targeted
therapies
are
essential
for
improving
prevention
treatment
strategies.
Inorganic
nanomaterials
have
gained
prominence
in
colorectal
owing
their
unique
size,
advantageous
properties,
modifiability.
Various
types
inorganic
nanomaterials—such
as
metal-based,
metal
oxide,
quantum
dots,
magnetic
nanoparticles,
carbon-based,
rare-earth
nanomaterials—have
demonstrated
potential
enhancing
multimodal
imaging,
delivery,
synergistic
therapies.
These
advancements
underscore
critical
role
therapeutic
outcomes.
This
review
highlights
properties
nanomaterials,
summarizes
recent
applications
progress
treatment,
discusses
challenges
translating
these
materials
into
clinical
use.
It
aims
provide
valuable
insights
future
research
application
management.
Язык: Английский
Surface Engineering‐Induced d‐Band Center Down‐Regulation in High‐Entropy Alloy Nanowires for Enhanced Nanozyme Catalysis
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Abstract
High‐entropy
alloys
(HEAs)
have
garnered
extensive
attention
owing
to
their
broad
compositional
tunability
and
high
catalytic
activity.
However,
precisely
modulating
the
enzyme‐like
activity
of
HEAs
enhancing
biocompatibility
for
biological
applications
remain
severely
challenging.
Herein,
PtRuFeCoNi
HEA
nanowires
(NWs)
are
synthesized
by
adjusting
metal
composition
surface‐engineered
with
polydopamine
(PDA)
form
NWs@PDA
nanozymes
(HEzymes@PDA)
superior
photothermal
properties.
Density
functional
theory
calculations
Sabatier
principle
reveal
that
self‐polymerized
PDA
surface
engineering
moderately
lowers
d‐band
center
HEAs,
optimizes
charge
distribution,
enhances
adsorption–desorption
efficiency
substrates.
As
a
proof‐of‐concept,
HEzymes@PDA
synergistically
integrated
hydrogels
biosensing
analysis.
This
study
presents
an
innovative
paradigm
designing
highly
active
via
demonstrates
immense
potential
in
sensing
applications.
Язык: Английский
Waste tobacco leaf-driven carbon dot nanozymes with high reactive oxygen species scavenging and anti-inflammatory activities for the amelioration of acute lung injury
Industrial Crops and Products,
Год журнала:
2025,
Номер
229, С. 120958 - 120958
Опубликована: Апрель 17, 2025
Язык: Английский
Mitochondrial 'Birth-Death' Coordinator: An Intelligent Hydrogen Nanogenerator to Enhance Intervertebral Disc Regeneration
Biomaterials,
Год журнала:
2024,
Номер
313, С. 122764 - 122764
Опубликована: Авг. 22, 2024
Язык: Английский
Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(47), С. 64536 - 64553
Опубликована: Ноя. 12, 2024
Liver
fibrosis
is
a
pathological
repair
response
that
occurs
after
sustained
liver
damage,
and
prompt
intervention
necessary
to
prevent
from
developing
into
potentially
life-threatening
condition.
In
long-term
injury,
damaged
hepatocytes
produce
excessive
amounts
of
reactive
oxygen
species
(ROS),
which
activate
hepatic
stellate
cells
(HSCs).
This
activation
leads
accumulation
extracellular
matrix
proteins
in
tissue.
Additionally,
macrophages
contribute
the
inflammatory
microenvironment
fibrotic
process,
exacerbating
through
ROS
production
secretion
pro-inflammatory
factors.
To
address
dysregulation
associated
with
fibrosis,
we
developed
cerium
oxide
nanozymes
using
hyaluronic
acid
(HA)
as
template
decorated
them
on
surface
liposomes
loaded
oleanolic
(OA).
We
named
this
prepared
obtained
target-engineered
liposome
HCOL.
The
inherent
superoxide
dismutase
(SOD)
catalase
(CAT)
activities
HCOL
enabled
it
effectively
scavenge
HSCs
alleviate
hypoxic
conditions
characteristic
livers.
Furthermore,
reduced
concentrations
macrophages,
promoting
shift
macrophage
polarization
M1
phenotype
anti-inflammatory
M2
phenotype.
transition
increased
cytokine
interleukin
10
(IL-10),
contributed
mitigation
microenvironment.
Consequently,
therapeutic
approach
proves
effective
decelerating
advancement
fibrosis.
Язык: Английский
Integrating multi-level interactive network analysis and in vivo studies to explore the protective mechanism of Maillard products of skipjack trypsin hydrolysate in hyperuricemia
Journal of Functional Foods,
Год журнала:
2024,
Номер
123, С. 106593 - 106593
Опубликована: Ноя. 21, 2024
Язык: Английский