International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10353 - 10353
Опубликована: Сен. 26, 2024
Organ
and
tissue
damage
can
result
from
injury
disease.
How
to
facilitate
regeneration
has
been
a
topic
for
centuries,
still,
we
are
trying
find
agents
use
treatments.
Two
groups
of
biological
substances
known
wound
healing.
Phytochemicals
with
bioactive
properties
form
one
group.
Many
phytochemicals
have
anti-inflammatory
effects
enhance
Recent
studies
described
their
at
the
gene
protein
expression
levels,
highlighting
receptors
signaling
pathways
involved.
The
extremely
large
number
multiple
types
they
activate
suggest
broad
range
applicability
clinical
use.
hydrophobic
nature
many
difficulty
chemical
stabilization
problem.
developments
in
biotechnology
nanotechnology
methods
enabling
researchers
overcome
these
problems.
other
group
is
extracellular
vesicles
(EVs),
which
now
important
functions,
including
improvement
proteins
nanoparticles
contained
mammalian
EVs
as
well
specificity
targets
microRNAs
included
becoming
clear.
Plant-derived
found
contain
phytochemicals.
overlap
wound-healing
capabilities
both
differences
possibility
combinatorial
two
groups,
may
effects.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
Wound
management
has
always
been
a
challenge
in
the
clinical
treatment
of
diabetes.
In
this
study,
glucose
oxidase
(GOx)
is
grafted
onto
natural
pullulan
polysaccharides,
and
oxidization
carried
out
to
form
self‐healing
hydrogel
using
carboxymethyl
chitosan
by
means
reversible
Schiff
base
covalent
bonding.
The
smart‐response
drug
release
properties
are
demonstrated
diabetic
wounds
taking
advantage
two
key
factors,
namely
pH‐responsive
nature
bonding
fact
that
GOx
reduces
pH
wounds.
To
further
enhance
biological
functions
dressing,
exosomes
(Exos)
introduced
into
system.
present
system
improves
high‐glucose
microenvironment
wounds,
releasing
H
2
O
impart
antimicrobial
effects,
ensuring
realizes
function.
component
used
construct
plays
an
effective
antibacterial
role.
Moreover,
Exos
loaded
effectively
promotes
neovascularization
wound.
also
regulates
macrophage
polarization
levels
persistent
inflammation
These
results
suggest
smart
responsive,
multifunctional,
dressing
ideal
for
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Regenerating
skin
tissue
remains
a
major
challenge
in
medical
science,
especially
due
to
the
risk
of
scarring
and
prolonged
healing,
which
becomes
even
more
complicated
people
with
diabetes.
Recent
advancements
have
led
creation
therapeutic
dressings
incorporating
drug‐delivery
systems
tackle
these
issues.
Exosomes
(Exos)
derived
from
mesenchymal
stem
cells
(MSCs)
gained
significant
attention
for
mediating
therapy
without
directly
using
cells,
thanks
their
natural
anti‐inflammatory
repair
properties
mirroring
those
MSCs.
In
this
study,
an
advanced
wound
dressing
combines
chitosan
(CS)
polyethylene
glycol
(PEG)
hydrogel
adipose
MSCs‐derived
Exos
(ADMSCs‐Exos).
This
composite,
formed
straightforward
blending
technique,
is
engineered
improve
healing
process
severe
injuries
by
steadily
releasing
as
degrades.
The
vitro
studies
demonstrate
that
hydrogel‐exosome
greatly
enhances
endothelial
cell
migration,
reduces
oxidative
stress,
promotes
angiogenesis,
crucial
effective
healing.
Additionally,
real
time‐polymerase
chain
reaction
(RT‐PCR)
analysis
revealed
upregulation
key
genes
involved
processes,
supporting
potential
hydrogel‐Exo
combination.
These
findings
emphasize
hydrogel‐Exos
combination
innovative
promising
solution
care.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 27, 2025
Diabetic
wounds
are
characterized
by
chronic
inflammation,
reduced
angiogenesis,
and
insufficient
collagen
deposition,
leading
to
impaired
healing.
Extracellular
vesicles
(EVs)
derived
from
adipose-derived
mesenchymal
stem
cells
(ADSC)
offer
a
promising
cell-free
therapeutic
strategy,
yet
their
efficacy
immunomodulation
can
be
enhanced
through
bioactivation.
In
this
study,
we
developed
calcium
silicate
(CS)-stimulated
ADSC-derived
EVs
(CSEV)
incorporated
into
hydrogels
create
sustained-release
system
for
promoting
diabetic
wound
CSEV
exhibited
protein
content,
surface
marker
expression,
bioactive
cargo
enriched
with
pro-angiogenic
anti-inflammatory
factors.
vitro,
CSEV-loaded
significantly
reactive
oxygen
species
production,
promoted
cell
proliferation
migration
compared
standard
EV-loaded
collagen.
Cytokine
profiling
revealed
the
upregulation
of
cytokines
extracellular
matrix
components,
highlighting
immunomodulatory
regenerative
potential.
vivo,
histological
evaluation
rabbit
models
treated
superior
reepithelialization
organized
indicating
accelerated
closure.
These
findings
underscore
potential
as
an
innovative
effective
platform
enhancing
healing
simultaneously
addressing
inflammation
tissue
regeneration.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Diabetic
wound
healing
remains
a
significant
challenge
due
to
complex
pathological
mechanisms,
including
prolonged
inflammation,
excessive
reactive
oxygen
species
(ROS)
accumulation,
angiogenesis
dysfunction,
and
increased
susceptibility
bacterial
infection.
In
this
study,
we
developed
dual
ROS/glucose-responsive
quercetin-loaded
supramolecular
hydrogel
(GPQ
hydrogel)
for
treating
diabetic
wounds.
The
was
fabricated
by
incorporating
quercetin
(QUE)
into
guanosine–phenylboronic
acid
(GP)
network
through
dynamic
borate
ester
bonds.
Structural
characterization
revealed
the
formation
of
typical
G-quadruplex
structure
in
GPQ
hydrogel.
responsiveness
ROS
glucose
enabled
controlled
release
QUE,
effectively
addressing
abnormal
microenvironment
diabetes.
vitro
studies
demonstrated
excellent
antibacterial,
antioxidant,
anti-inflammatory,
pro-angiogenic
properties
Furthermore,
vivo
study
using
full-thickness
model
streptozotocin-induced
rats
showed
that
significantly
accelerated
closure,
enhanced
re-epithelialization
collagen
deposition,
promoted
compared
control
GP
groups.
Immunofluorescence
analysis
confirmed
superior
antioxidant
effects
microenvironment.
This
presents
promising
multifunctional
biomaterial
managing
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 11, 2025
Epithelial
ovarian
cancer
(EOC),
one
of
the
most
prevalent
subtypes
cancer,
has
a
5-year
survival
rate
less
than
30%,
highlighting
urgent
need
for
novel
diagnostic
and
therapeutic
strategies.
The
tumor
microenvironment
(TME),
critical
regulator
progression,
includes
various
components,
among
which
small
extracellular
vesicles
(sEVs)
serve
as
important
molecular
carriers,
having
gained
attention
significant
contributors
to
biology.
These
vesicles,
released
by
cells
into
space,
are
pivotal
in
pathogenesis
EOC.
In
addition,
sEVs
show
promise
biomarkers
agents
treatment
management
this
malignancy.
This
review
explores
recent
advancements
understanding
within
TME
their
potential
applications
diagnosis
