Reticulophagy promotes EMT-induced fibrosis in offspring’s lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m5C-dependent manner DOI
Zhe Du, Qingping Liu,

Mengruo Wang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 485, С. 136873 - 136873

Опубликована: Дек. 13, 2024

Язык: Английский

The potential therapeutic effect of human umbilical cord mesenchymal stem cell-derived exosomes in bronchopulmonary dysplasia DOI

Tianyu Cheng,

Min Mao, Yang Liu

и другие.

Life Sciences, Год журнала: 2024, Номер 357, С. 123047 - 123047

Опубликована: Сен. 12, 2024

Язык: Английский

Процитировано

5
Cetuximab-Immunoliposomes Loaded with TGF-β1 siRNA for the Targeting Therapy of NSCLC: Design, and In Vitro and In Vivo Evaluation DOI Open Access
Yanan Shi,

Houqian Zhang,

Hao Chen

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1196 - 1196

Опубликована: Янв. 30, 2025

Transforming growth factor-β1 (TGF-β1) promotes the and metastasis of lung cancer cells. Therefore, TGF-β1 siRNA (siTGF-β1) gene therapy was introduced to inhibit expression at nucleic acid level avert tumor metastasis. However, delivery naked is typically restricted by a short half-life in vivo, difficulties safety issues. Using siTGF-β1 as model drug, we established an actively targeted immunoliposome system investigate role non-small-cell (NSCLC). The results showed that constructed immune liposomes were position deliver cells, thus achieving series effects such improving poor stability siRNA. RNA interference reduced cell viability, growth, migration potential human non-small cells (A549). Moreover, A549 tumor-bearing nude mouse model, transfection markedly volume. Inhibiting diminished viability promoted apoptosis NSCLC, confirmed findings this study. targeting with immunoliposomes may be new therapeutic strategy for treating cancer.

Язык: Английский

Процитировано

0
Exosomes: A Promising Drug Delivery Tool in Hepatic Drug Delivery DOI
Neha Kanojia,

Komal Thapa,

Thakur Gurjeet Singh

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106761 - 106761

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Iguratimod improves bleomycin-induced pulmonary inflammation and fibrosis by regulating macrophage polarization through inhibiting the TLR4/NF-κB pathway DOI Creative Commons
Huan Xu,

Koval' Ma,

Z. Ma

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 13, 2025

Introduction Pulmonary fibrosis (PF) is a fatal pathological subtype of interstitial lung disease, frequently manifests as pulmonary complication connective tissue disease. Iguratimod (IGU) new class anti-rheumatic drugs used in the treatment rheumatoid arthritis (RA). Studies have reported that RA patients treated with IGU better function, and effectively ameliorates PF. However, mechanism by which improves PF still unclear. This study aims to elucidate therapeutic efficacy mechanisms through vivo vitro investigations, so provide method for Methods In our research, bleomycin (BLM)-induced mice were observe effect different concentrations IGU. And effects on macrophage polarization activation pathway TLR4/NF-κB analyzed. addition, Raw264.7 macrophages induced M1 M2 vitro, related pathways observed. Results study, database analysis suggested polarization-relative genes well TLR4 played important roles BLM-induced mice. Besides, we found ameliorated epithelial-mesenchymal transition mice, inhibited M1/M2 at stages Moreover, studies further demonstrated suppressed its TLR4/NF-κB. Discussion summary, inhibits inhibiting pathway, thereby improving inflammation It may be option fibrosis.

Язык: Английский

Процитировано

0
Loading milk exosomes with urolithins boosts their delivery to the brain: Comparing the activity of encapsulated vs. free urolithins in SH-SY5Y neuroblastoma cells DOI Creative Commons
María Ángeles Ávila‐Gálvez,

Salvador Romero-Reyes,

María‐Carmen López de las Hazas

и другие.

Food Bioscience, Год журнала: 2024, Номер 61, С. 104888 - 104888

Опубликована: Авг. 6, 2024

The gut microbial-derived metabolites of ellagitannins and ellagic acid, urolithins (Uros) are well-established anti-cancer according to preclinical studies. However, their efficacy is limited in systemic tissues, including the brain, by phase-II metabolism. Exosomes (EXOs), extracellular vesicles involved cell signaling with ability cross blood-brain barrier (BBB), could protect polyphenols from Therefore, we loaded milk EXOs Uro-A, Uro-B or IsoUro-A evaluate brain delivery anticancer effects compared non-encapsulated Uros. In Sprague-Dawley rats, perfused tissue analyses UPLC-ESI-QTOF-MS showed higher Uro levels (∼3−4-fold) at 5 min following intravenous administration EXO-Uros Uros, except for Uro-B, using similar concentrations (17−30 μM). Experiments on neuroblastoma SH-SY5Y cells revealed dose-dependent antiproliferative all (0.3−1.2 μM), but not Uros (10 Flow cytometry indicated that only arrested cycle induced apoptosis. Finally, fluorescent-labeled selective inhibitors, primary endocytic pathway was be clathrin-dependent. Overall, encapsulating into promising enhancing activity.

Язык: Английский

Процитировано

2
Food-derived exosomes as the future of drug delivery DOI
Bin Yang, Miao Zhang,

Lixia Yue

и другие.

Nano Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Язык: Английский

Процитировано

0
Reticulophagy promotes EMT-induced fibrosis in offspring’s lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m5C-dependent manner DOI
Zhe Du, Qingping Liu,

Mengruo Wang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 485, С. 136873 - 136873

Опубликована: Дек. 13, 2024

Язык: Английский

Процитировано

0