Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells
International Immunopharmacology,
Год журнала:
2025,
Номер
150, С. 114228 - 114228
Опубликована: Фев. 12, 2025
Glioma-associated
mesenchymal
stem
cells
(GA-MSCs)
are
one
of
the
key
factors
limiting
effectiveness
glioblastoma
(GBM)
treatment
and
contributing
to
poor
patient
prognosis,
making
them
a
potential
therapeutic
target
for
GBM.
In-depth
research
into
complex
crosstalk
between
GA-MSCs
GBM
not
only
aids
in
understanding
mechanisms
progression
but
also
provides
valuable
insights
developing
new
drugs.
We
conducted
comprehensive
bioinformatics
analysis
aimed
at
identifying
shared
dysregulated
genes
GA-MSCs.
Through
hub
gene
enrichment
immune
infiltration
analyses,
we
explored
molecular
pathways
landscape.
Additionally,
Cox
regression
was
employed
identify
influencing
overall
survival
The
expression
patterns
functional
roles
were
validated
across
various
cancer
types
datasets.
Finally,
dynamic
simulations
used
assess
binding
affinity
drugs
targets,
further
supporting
their
as
candidates.
identified
32
candidate
primarily
involved
1-kappa-B
kinase/NF-kappa-B
MAPK
signaling
pathways,
both
which
played
critical
tumor
survival,
proliferation,
invasion.
Notable
included
DUSP1,
FYN,
FLNC,
FN1,
G3BP1,
MYO1B,
WLS,
each
uniquely
progression.
Among
them,
FLNC
highlighted
regulatory
factor
Molecular
dynamics
revealed
its
target,
particularly
demonstrating
high
with
staurosporine.
proportion
dendritic
contributed
formation
microenvironment.
This
study
co-expression
metabolic
GBM,
providing
Targeting
staurosporine
presents
promising
strategy
Aditionally,
targeting
may
offer
approach
treating
malignant
brain
tumors.
Язык: Английский
Interleukin 8 Molecular Interplay in Allergic Rhinitis and Chronic Rhinosinusitis with Nasal Polyps: A Scoping Review
Life,
Год журнала:
2025,
Номер
15(3), С. 469 - 469
Опубликована: Март 15, 2025
The
present
scoping
review
underlines
the
molecular
interplay
between
allergic
rhinitis
(AR),
chronic
rhinosinusitis
with
nasal
polyps
(CRSwNP),
and
interleukin-8
(IL-8).
A
query
of
PubMed
database
resulted
in
inclusion
34
articles
final
analysis
this
review.
IL-8
is
one
interconnecting
immune
mediator
physiopathology
AR
CRS.
An
influx
cytokines,
such
as
interleukin
(IL)-4
IL-13,
occurs
from
mast
cells,
four
to
six
hours
after
initial
response
signifying
development
late-phase
allowing
entrance
eosinophils,
basophils,
T-lymphocytes
at
level
mucosa.
Chronic
(CRS)
a
inflammatory
disease
that
mucosa
cavity
sinuses
two
external
phenotypes,
but
mechanisms
overlap
rhinitis.
Interleukin
8
induces
neutrophil
chemokinetic
movement
providing
chemotactic
or
directional
cue.
Clinical
fundamental
studies
established
an
implication
mechanism
CRSwNP.
Moreover,
there
still
missing
randomized,
large-cohort
study
three
patients
groups
(normal
control,
AR,
CRSwNP)
analyzes
impact
simultaneously.
Future
possible
developments
could
focus
on
target
for
biologic
treatments.
Язык: Английский
Application of Nanoparticles for Immunotherapy of Allergic Rhinitis
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12015 - 12037
Опубликована: Ноя. 1, 2024
Allergen
Immunotherapy
(AIT)
is
the
only
etiological
therapeutic
method
available
for
allergic
rhinitis
(AR).
Currently,
several
options
AIT
in
market,
such
as
subcutaneous
immunotherapy
(SCIT)
and
sublingual
(SLIT),
have
different
routes
of
administration.
These
traditional
methods
achieved
encouraging
outcomes
clinic.
However,
side
effects
associated
with
these
raised
need
innovative
approaches
that
improve
safety,
shorten
course
treatment
increase
local
drug
concentration.
Nanoparticles
(NPs)
are
particles
ranging
size
from
1
to
100
nm,
which
been
hired
potential
adjuvants
AIT.
NPs
can
be
employed
agents
modulating
immune
responses
AR
or/and
carriers
loading
proteins,
peptides
or
DNA
molecules.
This
review
focuses
on
kinds
nanoparticle
delivery
systems,
including
chitosan
nanoparticles,
exosomes,
metal
viral
nanoparticles.
We
summarized
advantages
limitations
rhinitis.
Overall,
expected
a
option
AR,
requires
more
in-depth
studies
long-term
validation.
Язык: Английский