Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114228 - 114228

Published: Feb. 12, 2025

Glioma-associated mesenchymal stem cells (GA-MSCs) are one of the key factors limiting effectiveness glioblastoma (GBM) treatment and contributing to poor patient prognosis, making them a potential therapeutic target for GBM. In-depth research into complex crosstalk between GA-MSCs GBM not only aids in understanding mechanisms progression but also provides valuable insights developing new drugs. We conducted comprehensive bioinformatics analysis aimed at identifying shared dysregulated genes GA-MSCs. Through hub gene enrichment immune infiltration analyses, we explored molecular pathways landscape. Additionally, Cox regression was employed identify influencing overall survival The expression patterns functional roles were validated across various cancer types datasets. Finally, dynamic simulations used assess binding affinity drugs targets, further supporting their as candidates. identified 32 candidate primarily involved 1-kappa-B kinase/NF-kappa-B MAPK signaling pathways, both which played critical tumor survival, proliferation, invasion. Notable included DUSP1, FYN, FLNC, FN1, G3BP1, MYO1B, WLS, each uniquely progression. Among them, FLNC highlighted regulatory factor Molecular dynamics revealed its target, particularly demonstrating high with staurosporine. proportion dendritic contributed formation microenvironment. This study co-expression metabolic GBM, providing Targeting staurosporine presents promising strategy Aditionally, targeting may offer approach treating malignant brain tumors.

Language: Английский

Interleukin 8 Molecular Interplay in Allergic Rhinitis and Chronic Rhinosinusitis with Nasal Polyps: A Scoping Review

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 469 - 469

Published: March 15, 2025

The present scoping review underlines the molecular interplay between allergic rhinitis (AR), chronic rhinosinusitis with nasal polyps (CRSwNP), and interleukin-8 (IL-8). A query of PubMed database resulted in inclusion 34 articles final analysis this review. IL-8 is one interconnecting immune mediator physiopathology AR CRS. An influx cytokines, such as interleukin (IL)-4 IL-13, occurs from mast cells, four to six hours after initial response signifying development late-phase allowing entrance eosinophils, basophils, T-lymphocytes at level mucosa. Chronic (CRS) a inflammatory disease that mucosa cavity sinuses two external phenotypes, but mechanisms overlap rhinitis. Interleukin 8 induces neutrophil chemokinetic movement providing chemotactic or directional cue. Clinical fundamental studies established an implication mechanism CRSwNP. Moreover, there still missing randomized, large-cohort study three patients groups (normal control, AR, CRSwNP) analyzes impact simultaneously. Future possible developments could focus on target for biologic treatments.

Language: Английский

Application of Nanoparticles for Immunotherapy of Allergic Rhinitis

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12015 - 12037

Published: Nov. 1, 2024

Allergen Immunotherapy (AIT) is the only etiological therapeutic method available for allergic rhinitis (AR). Currently, several options AIT in market, such as subcutaneous immunotherapy (SCIT) and sublingual (SLIT), have different routes of administration. These traditional methods achieved encouraging outcomes clinic. However, side effects associated with these raised need innovative approaches that improve safety, shorten course treatment increase local drug concentration. Nanoparticles (NPs) are particles ranging size from 1 to 100 nm, which been hired potential adjuvants AIT. NPs can be employed agents modulating immune responses AR or/and carriers loading proteins, peptides or DNA molecules. This review focuses on kinds nanoparticle delivery systems, including chitosan nanoparticles, exosomes, metal viral nanoparticles. We summarized advantages limitations rhinitis. Overall, expected a option AR, requires more in-depth studies long-term validation.

Language: Английский