Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway
Brain Research Bulletin,
Год журнала:
2025,
Номер
unknown, С. 111200 - 111200
Опубликована: Янв. 1, 2025
Electroacupuncture
(EA)
and
trigonelline
(TG)
have
been
reported
to
be
beneficial
in
alleviating
cerebral
ischemia/reperfusion
injury
(CIRI).
However,
the
synergistic
effects
of
EA
TG
CIRI
underlying
mechanism
not
demonstrated.
Rats
were
subjected
middle
artery
occlusion
(MCAO)
surgery
reperfusion
(MCAO/R)
establish
a
model.
Neurological
deficit
score
was
evaluated
using
Garcia's
scale.
Cerebral
infarction
rats
determined
TTC
staining.
Brain
tissue
morphology
assessed
by
HE
The
expression
various
proteins
measured
IF
assay
western
blot.
or
treatment
could
effectively
ameliorate
neurological
disorders,
attenuate
reduce
neuronal
damage
brain
rats.
In
addition,
suppressed
autophagy
pyroptosis
More
importantly,
intervention
observed
ameliorating
suppressing
pyroptosis,
while
Rapa,
an
inducer
autophagy,
strengthened
these
MCAO/R-induced
Furthermore.
Rapa
reversed
combination
with
TG-mediated
improvement
suppression
Notably,
PI3K/AKT/mTOR
pathway
inactivated
combined
enhanced
activation
pathway.
LY294002,
inhibitor
pathway,
stimulated
pyroptosis.
which
dependent
on
inhibition
through
signaling
Язык: Английский
Macrophage Pyroptosis in Atherosclerosis: Therapeutic Potential
Acta Biochimica et Biophysica Sinica,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Atherosclerosis
(AS)
is
a
chronic
inflammatory
disease
characterized
by
the
accumulation
of
lipid-rich
plaques
in
arterial
walls,
leading
to
cardiovascular
events
such
as
myocardial
infarction
and
stroke.
Macrophage
pyroptosis,
form
programmed
cell
death
driven
NLRP3
inflammasome
caspase-1
activation,
plays
critical
role
progression
destabilization
atherosclerotic
plaques.
This
review
explores
molecular
mechanisms
underlying
macrophage
pyroptosis
their
significant
contributions
AS
pathogenesis.
Recent
advancements
have
highlighted
therapeutic
potential
targeting
key
components
pyroptotic
pathway,
including
use
nanotechnology
increase
drug
delivery
specificity.
These
strategies
are
promising
for
reducing
inflammation,
stabilizing
plaques,
mitigating
clinical
impact
AS.
Future
studies
should
focus
on
translating
these
findings
into
applications
develop
effective
treatments
that
can
halt
or
reverse
modulating
pyroptosis.
Язык: Английский
Nanomaterials‐Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine
Small Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Abstract
Pyroptosis,
a
form
of
programmed
cell
death
characterized
by
lysis
and
inflammation,
has
significant
implications
for
disease
treatment.
Nanomaterials
(NMs),
with
their
unique
physicochemical
properties,
can
precisely
modulate
pyroptosis,
offering
novel
intelligent
therapeutic
strategies
cancer,
infectious
diseases,
chronic
inflammatory
conditions
targeted
activation
reduced
systemic
toxicity.
This
review
explores
the
mechanisms
which
NMs
regulate
comparing
molecular
NM
inducers,
examines
role
intrinsic
properties
such
as
size,
shape,
surface
charge,
chemical
composition
in
these
processes.
It
also
discusses
balance
between
beneficial
adverse
effects
NM‐induced
highlighting
delivery
systems,
modifications,
controlled
to
enhance
efficacy
intelligence
while
minimizing
Notably,
mRNA‐based
nanomedicine
be
intelligently
designed
activate
achieving
desired
outcomes
tailored
evolving
microenvironment
diseases.
By
understanding
interactions,
potential
harnessed
develop
innovative
treatments
manage
pyroptosis‐associated
diseases
safely,
effectively,
intelligently.
highlights
transformative
clinical
applications.
Язык: Английский
The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis
Cell Biochemistry and Biophysics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Язык: Английский
Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Ноя. 7, 2024
Tumor-associated
macrophages
(TAMs)
play
a
pivotal
role
in
sculpting
the
tumor
microenvironment
and
influencing
cancer
progression,
particularly
through
their
interactions
with
various
forms
of
regulated
cell
death
(RCD),
including
apoptosis,
pyroptosis,
ferroptosis,
necroptosis.
This
review
examines
interplay
between
TAMs
these
RCD
pathways,
exploring
mechanisms
which
they
interact
to
promote
growth
advancement.
We
examine
underlying
intricate
interactions,
emphasizing
importance
progression
treatment.
Moreover,
we
present
potential
therapeutic
strategies
for
targeting
manipulating
enhance
anti-tumor
responses.
These
encompass
reprogramming
TAMs,
inhibiting
recruitment,
selectively
eliminating
them
functions,
alongside
modulating
pathways
amplify
immune
insights
offer
novel
perspective
on
biology
provide
foundation
development
more
efficacious
therapies.
Язык: Английский