Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology DOI Creative Commons

Yifei Ge,

Lili Jiang,

Chengru Yang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 7, 2024

Tumor-associated macrophages (TAMs) play a pivotal role in sculpting the tumor microenvironment and influencing cancer progression, particularly through their interactions with various forms of regulated cell death (RCD), including apoptosis, pyroptosis, ferroptosis, necroptosis. This review examines interplay between TAMs these RCD pathways, exploring mechanisms which they interact to promote growth advancement. We examine underlying intricate interactions, emphasizing importance progression treatment. Moreover, we present potential therapeutic strategies for targeting manipulating enhance anti-tumor responses. These encompass reprogramming TAMs, inhibiting recruitment, selectively eliminating them functions, alongside modulating pathways amplify immune insights offer novel perspective on biology provide foundation development more efficacious therapies.

Language: Английский

Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway DOI Creative Commons

Zhengguo Qiu,

Jianbing Ma, Xiaqing Zhang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111200 - 111200

Published: Jan. 1, 2025

Electroacupuncture (EA) and trigonelline (TG) have been reported to be beneficial in alleviating cerebral ischemia/reperfusion injury (CIRI). However, the synergistic effects of EA TG CIRI underlying mechanism not demonstrated. Rats were subjected middle artery occlusion (MCAO) surgery reperfusion (MCAO/R) establish a model. Neurological deficit score was evaluated using Garcia's scale. Cerebral infarction rats determined TTC staining. Brain tissue morphology assessed by HE The expression various proteins measured IF assay western blot. or treatment could effectively ameliorate neurological disorders, attenuate reduce neuronal damage brain rats. In addition, suppressed autophagy pyroptosis More importantly, intervention observed ameliorating suppressing pyroptosis, while Rapa, an inducer autophagy, strengthened these MCAO/R-induced Furthermore. Rapa reversed combination with TG-mediated improvement suppression Notably, PI3K/AKT/mTOR pathway inactivated combined enhanced activation pathway. LY294002, inhibitor pathway, stimulated pyroptosis. which dependent on inhibition through signaling

Language: Английский

Citations

0
Macrophage Pyroptosis in Atherosclerosis: Therapeutic Potential DOI Creative Commons

Jian-ying Ma,

Yixian Wang, W. Xu

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Atherosclerosis (AS) is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques in arterial walls, leading to cardiovascular events such as myocardial infarction and stroke. Macrophage pyroptosis, form programmed cell death driven NLRP3 inflammasome caspase-1 activation, plays critical role progression destabilization atherosclerotic plaques. This review explores molecular mechanisms underlying macrophage pyroptosis their significant contributions AS pathogenesis. Recent advancements have highlighted therapeutic potential targeting key components pyroptotic pathway, including use nanotechnology increase drug delivery specificity. These strategies are promising for reducing inflammation, stabilizing plaques, mitigating clinical impact AS. Future studies should focus on translating these findings into applications develop effective treatments that can halt or reverse modulating pyroptosis.

Language: Английский

Citations

0
Nanomaterials‐Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine DOI Creative Commons

Siqi Yu,

Yumo Zhang,

Zhuoran Zhou

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Pyroptosis, a form of programmed cell death characterized by lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel intelligent therapeutic strategies cancer, infectious diseases, chronic inflammatory conditions targeted activation reduced systemic toxicity. This review explores the mechanisms which NMs regulate comparing molecular NM inducers, examines role intrinsic properties such as size, shape, surface charge, chemical composition in these processes. It also discusses balance between beneficial adverse effects NM‐induced highlighting delivery systems, modifications, controlled to enhance efficacy intelligence while minimizing Notably, mRNA‐based nanomedicine be intelligently designed activate achieving desired outcomes tailored evolving microenvironment diseases. By understanding interactions, potential harnessed develop innovative treatments manage pyroptosis‐associated diseases safely, effectively, intelligently. highlights transformative clinical applications.

Language: Английский

Citations

0
The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis DOI

Shaocong Wang,

Xinzhe Chen, Kun Wang

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology DOI Creative Commons

Yifei Ge,

Lili Jiang,

Chengru Yang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 7, 2024

Tumor-associated macrophages (TAMs) play a pivotal role in sculpting the tumor microenvironment and influencing cancer progression, particularly through their interactions with various forms of regulated cell death (RCD), including apoptosis, pyroptosis, ferroptosis, necroptosis. This review examines interplay between TAMs these RCD pathways, exploring mechanisms which they interact to promote growth advancement. We examine underlying intricate interactions, emphasizing importance progression treatment. Moreover, we present potential therapeutic strategies for targeting manipulating enhance anti-tumor responses. These encompass reprogramming TAMs, inhibiting recruitment, selectively eliminating them functions, alongside modulating pathways amplify immune insights offer novel perspective on biology provide foundation development more efficacious therapies.

Language: Английский

Citations

0